Relationship between the expression of PSMB2 and proliferation and invasion in glioma

He, Wei; Zhang, Zhe; Tan, Zilong; Liu, Xinxian; Wang, Zekun; Xiong, Bin; Shen, Xiaoli; Zhu, Xiang Yang

doi:10.21203/rs.3.rs-2751848/v1

Cited by 1 publication

(1 citation statement)

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“…Its levels are significantly increased in various cancers, including HCC. In addition, PSMB2 is a member of proteasome 20S core beta subunit, which plays several roles in many types of cancers, such as gastric cancer [17] or glioma [18]. Previous studies have reported that PSMB2 was regulated by NUDT21.…”

Section: Discussionmentioning

confidence: 99%

Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma

Huang,

Rau,

Liu

et al. 2023

IJMS

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Hepatocellular carcinoma (HCC) is associated with high rates of metastasis and recurrence, and is one of the most common causes of cancer-associated death worldwide. This study examined the protein changes within circulating exosomes in patients with HCC against those in healthy people using isobaric tags for a relative or absolute quantitation (iTRAQ)-based quantitative proteomics analysis. The protein levels of von Willebrand factor (VWF), cathelicidin antimicrobial peptide (CAMP), and proteasome subunit beta type-2 (PSMB2) were altered in HCC. The increased levels of VWF and PSMB2 but decreased CAMP levels in the serum of patients with HCC were validated by enzyme-linked immunosorbent assays. The level of CAMP (the only cathelicidin found in humans) also decreased in the circulating exosomes and buffy coat of the HCC patients. The serum with reduced levels of CAMP protein in the HCC patients increased the cell proliferation of Huh-7 cells; this effect was reduced following the addition of CAMP protein. The depletion of CAMP proteins in the serum of healthy people enhances the cell proliferation of Huh-7 cells. In addition, supplementation with synthetic CAMP reduces cell proliferation in a dose-dependent manner and significantly delays G1-S transition in Huh-7 cells. This implies that CAMP may act as a tumor suppressor in HCC.

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Section: Discussionmentioning

confidence: 99%