Relationship between the endothelial glycocalyx and the extent of coronary atherosclerosis

Xue, Xianjun; Jiang, Yan; Chen, Liang; Chen, Shao‐Liang

doi:10.1111/micc.12504

Cited by 17 publications

(15 citation statements)

References 20 publications

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“…In sublingual microvessels, vascular endothelial glycocalyx was thinned according to the severity of atherosclerotic lesions in coronary arteries, and circulating levels of hyaluronic acid in coronary arteries was significantly high in these patients 48 . In patients with ischemic heart disease and its highrisk patients, high PBR was extracted as a high-risk factor for arteriosclerotic cerebrovascular disease and ischemic heart disease, and PBR was associated with systolic blood pressure 49 .…”

Section: Ischemic Heart Diseasementioning

confidence: 92%

Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx

Yamaoka‐Tojo¹

2020

Preprint

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In atherosclerosis patients, vascular endothelial dysfunction is commonly observed with damage of vascular endothelial glycocalyx, an extracellular matrix-bound to and encapsulating the endothelial cell lining the blood vessel wall. Unfavorable lifestyle; smoking and physical inactivity, also induces glycocalyx degradation. Moreover, the vascular endothelial glycocalyx is damaged by various unfavorable disease conditions like as dehydration, acute infectious disease, trauma, sepsis, ARDS, Kawasaki disease, preeclampsia, gestational diabetes mellitus, hypertension, diabetes, chronic kidney disease, atherosclerosis, stroke, dementia, microvascular angina, acute coronary syndrome, and heart failure. The vascular endothelial glycocalyx has been shown to be important not only as a physical cytoprotective barrier for vascular endothelial cells but also as a mechanism that regulates intracellular cell signaling. Therefore, vascular endothelial glycocalyx has great potential to explore new strategies for assessing the benefit conditions of our healthy vasculature.

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Section: Ischemic Heart Diseasementioning

confidence: 92%

Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx

Yamaoka‐Tojo¹

2020

Preprint

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“…В настоящий момент темнопольная микроскопия является одним из ведущих методов неинвазивной прижизненной оценки гликокаликса у человека [59]. Она уже применялась у пациентов с терминальной почечной недостаточностью [63] и при ишемической болезни сердца, использовалась в качестве вспомогательного показателя оценки выраженности коронарного атеро склероза [64], показала неблагоприятное прогностическое значение при отягощенной наследственности по сердечно-сосудистым заболеваниям [65], оценивалась при нейродегенеративных заболеваниях [48]. Так, в одной из работ [66] у пациентов с эпилепсией было получено значимое изменение толщины сублингвального гликокаликса, в другом исследовании [67] метод позволил прижизненно выявить снижение кровотока и плотности сосудов микроциркуляторного русла коры головного мозга при инсульте.…”

Section: прижизненные неинвазивные методы исследования эндотелиальногunclassified

The endothelial glycocalyx: research methods and prospects for their use in endothelial dysfunction assessment

Власов¹,

Лазовская²,

Shimanski³

et al. 2020

Regional blood circulation and microcirculation

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A modern concept of the endothelial dysfunction in the pathogenesis of many diseases includes the glycocalyx damage along with impaired of the morphology and function of endothelial cells. The glycocalyx is a gel-like submembrane complex of protein-carbohydrate, carbohydrate-lipid components and plasma molecules forming a three-dimensional network on the luminal surface of the endothelium. The features of the borderline location of endothelial glycocalyx in the vascular system determine various important functions: barrier, regulatory, anti-inflammatory, antithrombotic, mechanotransduction ones, etc. In recent years, due to the improvement of visualization methods endothelial glycocalyx structure has been detailed. Its physiological functions and the role in the development of some pathological conditions have been clarified. Modern methods of glycocalyx assessment include invasive and non-invasive research techniques. The most promising ones are dark-field microscopy and the determination of glycocalyx-associated biochemical markers. Endothelial glycocalyx damage is a universal pathogenetic component and the earliest marker of the development of most diseases. Therefore, the endothelial glycocalyx assessment refers to promising areas of research. The ability to correlate with other prognostic indicators allows us to consider the endothelial glycocalyx damage as a marker of the poor health prognosis. That is why, assessment of the endothelial glycocalyx condition will allow to personalize treatment and to prevent the diseases progression.

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“…[61] The level of eGC thickness and fragments in patients plasma can be used as auxiliary diagnostic indices to assess the severity of coronary atherosclerosis. [62] In transplantation, the eGC fragments may be useful biomarkers to predict organ acceptability and development of transplant outcomes. Therefore, interventions to protect the eGC may improve transplantation outcomes.…”

Section: Detection Of the Egc And Clinical Significancementioning

confidence: 99%

Endothelial glycocalyx as a potential theriapeutic target in organ injuries

Cao

Tang

Xia

et al. 2019

Chinese Medical Journal

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Objective: The endothelial glycocalyx (eGC) is a dynamic and multicomponent layer of macromolecules found at the surface of vascular endothelium, which is largely underappreciated. It has recently been recognized that eGC is a major regulator of endothelial function and may have therapeutic value in organ injuries. This study aimed to explore the role of the eGC in various pathologic and physiologic conditions, by reviewing the basic research findings pertaining to the detection of the eGC and its clinical significance. We also explored different pharmacologic agents used to protect and rebuild the eGC. Data sources: An in-depth search was performed in the PubMed database, focusing on research published after 2003 with keywords including eGC, permeability, glycocalyx and injuries, and glycocalyx protection. Study selection: Several authoritative reviews and original studies were identified and reviewed to summarize the characteristics of the eGC under physiologic and pathologic conditions as well as the detection and protection of the eGC. Results: The eGC degradation is closely associated with pathophysiologic changes such as vascular permeability, edema formation, mechanotransduction, and clotting cascade, together with neutrophil and platelet adhesion in diverse injury and disease states including inflammation (sepsis and trauma), ischemia-reperfusion injury, shock, hypervolemia, hypertension, hyperglycemia, and high Na + as well as diabetes and atherosclerosis. Therapeutic strategies for protecting and rebuilding the eGC should be explored through experimental test and clinical verifications. Conclusions: Disturbance of the eGC usually occurs at early stages of various clinical pathophysiologies which can be partly prevented and reversed by protecting and restoring the eGC. The eGC seems to be a promising diagnostic biomarker and therapeutic target in clinical settings.

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Relationship between the endothelial glycocalyx and the extent of coronary atherosclerosis

Abstract: EG damage was correlated with the occurrence and development of coronary atherosclerosis. The EG thickness in the capillaries of the oral submucosa and the intracoronary HA level can be used as auxiliary indexes to assess the severity of coronary atherosclerosis.

Cited by 17 publications

References 20 publications

Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx

Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx

The endothelial glycocalyx: research methods and prospects for their use in endothelial dysfunction assessment

Endothelial glycocalyx as a potential theriapeutic target in organ injuries

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