Relationship between the development of bronchial hyperresponsiveness and the airway eosinophilia in guinea pigs following injection with Sephadex beads

Specific increase of microvascular permeability in lower airways of guinea pigs injected with Sephadex beads

“…In sensitized guinea pigs challenged with ovalbumin, Evans blue dye extravasation was preferentially distributed in the intrapulmonary airways and was correlated with changes in tung resistance [3]. Interestingly, it has been shown previously that Sephadex treatment in guinea pigs increased the reactivity of the lower bronchus as early as 3 h after the treatment [8]. Although the participation of neural or non-neural mechanisms in Sephadex-induced microvascular leakage in guinea pigs was not investigated in the present study, preliminary results indicated that treatment with glucocorticoids reduced the plasma exudation in Sephadex-treated animals (unpublished data).…”