Relationship between the daily rhythms of locomotor  activity and body temperature in eight mammalian species

Refinetti, Roberto

doi:10.1152/ajpregu.1999.277.5.r1493

Cited by 80 publications

(68 citation statements)

References 33 publications

(50 reference statements)

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“…This activity-independent, daily or circadian regulation of temperature has been previously described in several rodent species (13,14), including the rat in which it relies on an intact SCN (15). Furthermore, our analysis clearly demonstrates that activity-independent CBT in the forced-desynchronized rat oscillates more robustly in accordance to a Ͼ24 h rhythm than to the entrained T 22 h rhythm.…”

Section: Resultssupporting

confidence: 80%

“…Accordingly, human subjects under a rest-activity (and respective dark and light phases) forced desynchrony protocol show both an endogenous free-running modulation of CBT but also behaviorally induced changes in CBT that are associated to the experimenterimposed rest-activity cycle (11,12). In animals, an imposed rest-activity cycle is not feasible and genuine circadian modulation of CBT must be statistically dissected from locomotor activity-induced rhythmic CBT (13).…”

Section: Resultsmentioning

confidence: 99%

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Circadian desynchronization of core body temperature and sleep stages in the rat

Cambras

Weller

Anglès-Pujoràs

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Proper functioning of the human circadian timing system is crucial to physical and mental health. Much of what we know about this system is based on experimental protocols that induce the desynchronization of behavioral and physiological rhythms within individual subjects, but the neural (or extraneural) substrates for such desynchronization are unknown. We have developed an animal model of human internal desynchrony in which rats are exposed to artificially short (22-h) light-dark cycles. Under these conditions, locomotor activity, sleep-wake, and slow-wave sleep (SWS) exhibit two rhythms within individual animals, one entrained to the 22-h light-dark cycle and the other free-running with a period >24 h ( >24 h). Whereas core body temperature showed two rhythms as well, further analysis indicates this variable oscillates more according to the >24 h rhythm than to the 22-h rhythm, and that this oscillation is due to an activity-independent circadian regulation. Paradoxical sleep (PS), on the other hand, shows only one freerunning rhythm. Our results show that, similarly to humans, (i) circadian rhythms can be internally dissociated in a controlled and predictable manner in the rat and (ii) the circadian rhythms of sleep-wake and SWS can be desynchronized from the rhythms of PS and core body temperature within individual animals. This model now allows for a deeper understanding of the human timekeeping mechanism, for testing potential therapies for circadian dysrhythmias, and for studying the biology of PS and SWS states in a neurologically intact model.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Circadian desynchronization of core body temperature and sleep stages in the rat

Cambras

Weller

Anglès-Pujoràs

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…The finding that different variables exhibit different degrees of rhythmicity is not surprising and has been previously described in laboratory rodents (Refinetti, 1999) and farm animals (Piccione et al, 2005). The finding is important, however, because of its implications concerning the issue of causality of daily rhythmicity (i.e., internal temporal order).…”

Section: Discussionsupporting

confidence: 52%

Daily rhythms of physiological parameters in the dromedary camel under natural and laboratory conditions

Alhaidary

Abdoun

Samara

et al. 2016

Research in Veterinary Science

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See next page for additional authorsThis is an author-produced, peer-reviewed version of this article. © 2016, Elsevier. Licensed under the Creative Commons NonCommercial-NoDerivs 4.0 license. Details regarding the use of this work can be found at: http://creativecommons.org/licenses/by-nc-nd/4.0/. Abstract Camels are well adapted to hot arid environments and can contribute significantly to the economy of developing countries in arid regions of the world. Full understanding of the physiology of camels requires understanding of the internal temporal order of the body, as reflected in daily or circadian rhythms. In the current study, we investigated the daily rhythmicity of 20 physiological variables in camels exposed to natural oscillations of ambient temperature in a desert environment and compared the daily temporal courses of the variables. We also studied the rhythm of core body temperature under experimental conditions with constant ambient temperature in the presence and absence of a light-dark cycle. The obtained results indicated that different physiological variables exhibit different degrees of daily rhythmicity and reach their daily peaks at different times of the day, starting with plasma cholesterol, which peaks 24 minutes after midnight, and ending with plasma calcium, which peaks 3 hours before midnight.Furthermore, the rhythm of core body temperature persisted in the absence of environmental rhythmicity, thus confirming its endogenous nature. The observed delay in the acrophase of core body temperature rhythm under constant conditions suggests that the circadian period is longer than 24 hours. Further studies with more refined experimental manipulation of different variables are needed to fully elucidate the causal network of circadian rhythms in dromedary camels.

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“…The finding that different variables exhibit different degrees of rhythmicity is not surprising. It was observed in other studies in which simultaneous recording of many variables was done (Refinetti, 1999;Piccione et al, 2005;Giannetto and Piccione, 2009).…”

Section: Discussionmentioning

confidence: 62%

Circadian rhythms of redox states and total locomotor activity in dairy cattle

Giannetto¹,

Fazio²,

Assenza³

et al. 2010

CZECH J ANIM SCI

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ABSTRACT:We want to study the circadian rhythm of dROMs and anti-oxidative power in dairy cattle during dry period and the possible involvement of the circadian organization of rest/activity cycles in the fluctuation of redox state. For this purpose we recorded TLA in five clinically healthy Bruna Italian dairy cattle by means of an actigraphy-based data logger, Actiwatch-Mini ® . Blood samples were collected every 3 hours over a 48-hour period for the assessment of free radicals (dROMs) and the antioxidant power: antioxidant barrier (Oxy-ads) and thiol-antioxidant barrier (SHp). All animals were in the same productive period (dry) and they were housed in the same stable under natural photoperiod and ambient temperature. One-way repeated measure ANOVA was used to determine a statistical significant effect of time on the studied parameters. A trigonometric statistical model was applied to characterize the main rhythmic parameters according to the single cosinor procedure. A significant effect of time on all studied parameters was observed. They showed a diurnal acrophase and different degrees of robustness of rhythms. In conclusion, we can claim that there is a synergism between the dROM circadian rhythm and the circadian rhythm of anti-oxidative power. These rhythms do not have any implication for the issue of causation with the TLA circadian rhythms.

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Relationship between the daily rhythms of locomotor activity and body temperature in eight mammalian species

Cited by 80 publications

References 33 publications

Circadian desynchronization of core body temperature and sleep stages in the rat

Circadian desynchronization of core body temperature and sleep stages in the rat

Daily rhythms of physiological parameters in the dromedary camel under natural and laboratory conditions

Circadian rhythms of redox states and total locomotor activity in dairy cattle

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