Relationship between the Concentrations of Heavy Metals and Bioelements in Aging Men with Metabolic Syndrome

Rotter, Iwona; Kosik-Bogacka, Danuta; Dołęgowska, Barbara; Safranow, Krzysztof; Lubkowska, Anna; Laszczyńska, Maria

doi:10.3390/ijerph120403944

Cited by 108 publications

(71 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inverse correlations between Ca with WC [23,63,64] and TG [23,65,66] contribute to the inverse relationship between Ca and MetS in this study, and these were found by other researchers too. We also observed moderately positive correlations between Ca with TC, HDL-C, LDL-C and FPG, as have been reported earlier [43,[67][68][69] .…”

Section: Discussionsupporting

confidence: 73%

“…However, in this study, we observed opposite correlations between Mg and BMI, blood pressure, blood lipid and blood glucose levels. Positive relationships of Mg with metabolic disorders like hypertension [18,49,50] and dyslipidemia [14,43] were also observed by several researchers previously.…”

Section: Discussionmentioning

confidence: 60%

“…Mg ions have been shown to inhibit hepatic lipase generation, regulate lipase activity, and have a direct effect on regulation of lipid metabolism [39] . Most previous studies in western countries reported a relationship between Mg deficiency and increased risk of MetS [40][41][42][43] . A meta-analysis conducted recently also found significantly a difference of Mg levels between adults with MetS and controls (standardized mean difference = -0.98, 95% CI -1.44 to -0.52) [44] .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood Are Positively Correlated with the Metabolic Syndrome in a Chinese Population: A Case-Control Study

Yuan

Liu²,

Tian³

et al. 2016

Ann Nutr Metab

View full text Add to dashboard Cite

Magnesium (Mg) and calcium (Ca) are essential for numerous kinds of metabolisms in human body. To investigate the associations between Mg and Ca and the ratio of Ca to Mg (Ca/Mg) in whole blood with metabolic syndrome (MetS) in a Chinese population, a matched case-control study including 204 MetS patients and 204 healthy controls (aged 48-89) was carried out in 2011. MetS were diagnosed according to the criteria of Chinese Diabetes Society. Controls had no abnormal metabolic components and were matched with cases by age, gender and region. Blood samples were collected in the morning after an overnight fast. Whole blood Mg and Ca were determined by flame atomic absorption spectrometry. Subjects who were male constituted 44.1% of the part of this study. The average age was 64.0 ± 7.18, and the average body mass index was 24.3 ± 3.75. The MetS group showed significantly higher Mg and lower Ca and Ca/Mg as compared with the control group. Comparing with the bottom tertile (T1) of Mg, increased ORs for MetS were found in median tertile (T2) and top tertile (T3) of Mg. For Ca, T2 and T3 were negatively associated with MetS. Inverse relationship was also found between Ca/Mg ratio and MetS. Our findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with MetS in Chinese adults.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood Are Positively Correlated with the Metabolic Syndrome in a Chinese Population: A Case-Control Study

Yuan

Liu²,

Tian³

et al. 2016

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Insulin resistance is not only a hallmark but also a pathogenic factor of T2DM. However, the quantitative relationship between dietary Se intake and insulin resistance has been only reported in studies with very small sample size [28,29] or special groups such as metabolic syndrome (MS) [30], obesity [31,32] and polycystic ovary syndrome (PCOS) patients [33]. A study with large sample size and a wide range of insulin resistance and dietary Se intake in a general population is required in order to understand the association between the two factors.…”

Section: Introductionmentioning

confidence: 99%

High dietary selenium intake is associated with less insulin resistance in the Newfoundland population

et al. 2017

View full text Add to dashboard Cite

As an essential nutrient, Selenium (Se) is involved in many metabolic activities including mimicking insulin function. Data on Se in various biological samples and insulin resistance are contradictory, moreover there is no large study available regarding the relationship of dietary Se intake with insulin resistance in the general population. To investigate the association between dietary Se intake and variation of insulin resistance in a large population based study, a total of 2420 subjects without diabetes from the CODING (Complex Diseases in the Newfoundland Population: Environment and Genetics) study were assessed. Dietary Se intake was evaluated from the Willett Food Frequency questionnaire. Fasting blood samples were used for the measurement of glucose and insulin. Insulin resistance was determined with the homeostasis model assessment (HOMA-IR). Body composition was measured using dual energy X-ray absorptiometry. Analysis of covariance showed that high HOMA-IR groups in both males and females had the lowest dietary Se intake (μg/kg/day) (p < 0.01), being 18% and 11% lower than low HOMA-IR groups respectively. Insulin resistance decreased with the increase of dietary Se intake in females but not in males after controlling for age, total calorie intake, physical activity level, serum calcium, serum magnesium, and body fat percentage (p < 0.01). Partial correlation analysis showed that dietary Se intake was negatively correlated with HOMA-IR after adjusting for the Se confounding factors in subjects whose dietary Se intake was below 1.6 μg/kg/day (r = -0.121 for males and -0.153 for females, p < 0.05). However, the negative correlation was no longer significant when dietary Se intake was above 1.6 μg/kg/day. Our findings suggest that higher dietary Se intake is beneficially correlated with lower insulin resistance when total dietary Se intake was below 1.6 μg/kg/day. Above this cutoff, this beneficial effect disappears.

show abstract

“…Diabetes associated oxidative stress is responsible for secondary complications of diabetes (González de Vega, Fernández-Sánchez, Fernández, Álvarez Menéndez, & Sanz-Medel, 2016;Kahya, Nazıroğlu, & Övey, 2016) so antioxidant supplements such as selenium seems to be highly desirable for the treatment of this disease and its complications (Kahya, Naziroğlu, & Çiğ, 2015;Feng et al, 2015). However, other studies have shown that there is a positive correlation between serum level of selenium and diabetes incidence (Laclaustra, Navas-Acien, Stranges, M. Ordovas, & Guallar, 2009;Stranges et al, 2007;Steinbrenner, Speckmann, Pinto, & Sies, 2011;Lu et al, 2016;Thompson et al, 2016;Farrokhian et al, 2016;Rotter et al, 2015;Bleys, Navas-Acien, & Guallar ,2007;Mueller, Mueller, Wolf, & Pallauf ,2009). …”

Section: Introductionmentioning

confidence: 99%

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Heidari

Sepehri

Doostdar

2016

GJHS

View full text Add to dashboard Cite

In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P<0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.

show abstract

Relationship between the Concentrations of Heavy Metals and Bioelements in Aging Men with Metabolic Syndrome

Cited by 108 publications

References 63 publications

Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood Are Positively Correlated with the Metabolic Syndrome in a Chinese Population: A Case-Control Study

Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood Are Positively Correlated with the Metabolic Syndrome in a Chinese Population: A Case-Control Study

High dietary selenium intake is associated with less insulin resistance in the Newfoundland population

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Contact Info

Product

Resources

About