Relationship Between the Comprehensive Nutritional Index and the EORTC QLQ-H&amp;N35 in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Radiation Therapy

He, Yan; Chen, Liping; Chen, Linmin; Hu, Wen; Tang, Lin‐Quan; Mai, Hai‐Qiang; Li, Jianmei; Wu, Liping; Fan, Yun

doi:10.1080/01635581.2017.1283422

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…For all the domains, an increase in scores in the middle of treatment, and maintenance of this higher score until the end of treatment, was observed. Other studies also observed an increase in scores for symptoms with greatest impact on nutrition after treatment [ 14 , 22 ], leading to a reduction in food intake and favoring the occurrence and/or worsening of nutritional status [ 31 , 32 ]. On the other hand, previous studies found a positive association between nutritional status and QoL [ 16 , 22 ], as expected.…”

Section: Discussionmentioning

confidence: 98%

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Lima

Ferreira

Lajolo

et al. 2020

Health Qual Life Outcomes

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Background Quality of life (QoL) is influenced in head and neck cancer (HNC) patients by a set of factors related to diagnosis, treatment and tumor impacts. The aim of this study was to evaluate the Quality of Life (QoL) changes in Head and Neck cancer (HNC) patients during treatment (radiotherapy and/or chemoradiotherapy). Methods QoL was evaluated prospectively in 63 HNC patients during radiotherapy and/or chemoradiotherapy at three moments: before or at beginning (T0), in the middle (T1 ~ four weeks) and immediately at the end (T2 ~ eight weeks) of treatment. The differences between the scores at different time points was verified using Friedman’s non-parametric test. Negative changes between time points were evaluated, with differences (delta) of ±10 points being considered to be clinically significant. Results The total mean age was 59.1 ± 9.5y, and 82.5% were male. The oral cavity and larynx were more frequent tumors. The functional score for ‘role’ was decreased at time points T1 and T2 as compared to T0, while an improvement in scores was observed for cognitive function. Several physical symptoms also worsened over time, such as: fatigue, nausea and vomiting, dry mouth and sticky saliva, swallowing and skin symptoms, senses and teeth problems. A high frequency of altered and clinically meaningful values were observed for most of domains, ranging from 6 to 74%. Conclusions The QoL became worse at approximately one month after treatment beginning in HNC patients, and this remained until the end of therapy. Protocols directing to early nutritional counseling and management of symptoms of nutritional impact are important to improve clinical outcomes. This is part of preventive actions aiming to make the exhausting treatment process less traumatic and easier to complete.

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Section: Discussionmentioning

confidence: 98%

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Lima

Ferreira

Lajolo

et al. 2020

Health Qual Life Outcomes

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“…For the group in total, the mean values of HRQoL scores were in general most severe at this time point. For patients treated with RT, this is the time point when the systematic daily support from the healthcare system during treatment ends, i.e., at a time point when nutritional status [16,17] and HRQoL [22,23] often are at their worse. This indicates the importance of extra support to the patients when returning home after treatment.…”

Section: Discussionmentioning

confidence: 99%

Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM

2021

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Patients with cancer deal with problems related to physical, psychological, social, and emotional functions. The aim was to investigate malnutrition defined by the Global Leadership Initiative on Malnutrition (GLIM) criteria in relation to health-related quality of life, anxiety, and depression in patients with head and neck cancer. This was a prospective observational research study with 273 patients followed at the start of treatment, seven weeks, and one year. Data collection included nutritional status and support, and the questionnaires: European Organization for Research and Treatment of Cancer Head and neck cancer module (EORTC QLQ-H&N35) and the Hospital Anxiety and Depression Scale (HADS). Malnutrition was defined using the GLIM criteria. The study showed that patients with malnutrition had significantly greater deterioration in their health-related quality of life at seven weeks. On a group level, health-related quality of life was most severe at this time point and some scores still implied problems at one year. Significantly, more patients reported anxiety at the start of treatment whereas significantly more patients reported depression at seven weeks. Over the trajectory of care, the need for support often varies. Psychosocial support is imperative and at the end of treatment extra focus should be put on nutritional interventions and managing treatment-related symptoms to improve nutritional status and health-related quality of life. In the long-term, head and neck cancer survivors need help to find strategies to cope with the remaining sequel.

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“…Several reports have confirmed that, [15][16][17][18][19] in patients with NPC, enteral nutrition treatment shown to decrease the CCRT toxicity, the weight loss, and the radiotherapy interruption rate. [21][22][23][24][25][26] Very little was found in the literature on the role of HEN in bone marrow suppression of patients with NPC. 20 WBC and PLT are also important indicators that affect the course of radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned in the literature review, most studies focused on the improvement of weight, quality of life, and dryness of mouth in patients with HNC during radiotherapy. [21][22][23][24][25][26] Very little was found in the literature on the role of HEN in bone marrow suppression of patients with NPC.…”

Section: Discussionmentioning

confidence: 99%

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

Zhou

Chu

et al. 2019

Head & Neck

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Background The aim of this study is to assess the effect of home enteral nutrition (HEN) on the myelosuppression of patients with nasopharyngeal cancer (NPC) during the course of concurrent chemoradiotherapy (CCRT). Methods A total of 18 outpatients with NPC administered oral nutritional supplementation intervention at home during the course of CCRT were designated as the HEN group, whereas 36 patients with NPC who had previously completed CCRT were retrospectively included as the control group. Patient Generated Subjective Global Assessment, body mass index (BMI), and blood test were evaluated prior to CCRT. During the course of CCRT, blood test was assessed every 2 weeks. Results In male patients, hemoglobin (HB) and red blood cell were decreased (P < .05) in both HEN and control group after CCRT, whereas white blood cell (WBC) started to decrease since week 2 of CCRT in the control group but maintained in the HEN group which was significantly higher than the control (5.05 ± 1.29 vs 3.77 ± 1.5, P < .05). In female patients, HB and WBC were reduced in control group during CCRT, whereas these indicators also maintained in the HEN group. Surprisingly, all patients with lower BMI (<24 kg/m2) had a significant increase in platelet (PLT) after CCRT (200.78 ± 58.03 vs 253.00 ± 69.82, P < .05), while had steady HB and WBC values in the HEN group. At the end of CCRT, WBC and PLT of the HEN group were both higher than those in the control group (5.21 ± 1.07 vs 3.37 ± 1.52), (253.00 ± 69.82 vs 165.57 ± 59.56) (P < .05 for both). Our findings suggest that HEN is effective in preventing myelosuppression during CCRT for patients with NPC. Conclusion Our findings suggest that HEN is effective in preventing myelosuppression during CCRT for patients with NPC.

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Relationship Between the Comprehensive Nutritional Index and the EORTC QLQ-H&N35 in Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Radiation Therapy

Cited by 14 publications

References 34 publications

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

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