Relationship between the carbohydrate metabolism ofStreptomyces aureofaciens and the biosynthesis of chlortetracycline

Hošťálek, Z.

doi:10.1007/bf02868790

Cited by 20 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is characterized by bacterial inhibition, promotion of animal growth, high availability in animal feed, minimal residue in animal tissues, and low production cost. In recent decades, CTC has been the most consumed antibiotic in animal feed industry [1]. The most important considerations for biochemical industry are high yield, quality, and profit.…”

Section: Introductionmentioning

confidence: 99%

Online prediction for contamination of chlortetracycline fermentation based on Dezert–Smarandache theory

Yang

Chen

Jin

2015

Chinese Journal of Chemical Engineering

View full text Add to dashboard Cite

Self-recursive wavelet neural network Unscented kalman filter Fermentative production of chlortetracycline is a complex fed-batch bioprocess. It generally takes over 90 h for cultivation and is often contaminated by undesired microorganisms. Once the fermentation system is contaminated to certain extent, the product quality and yield will be seriously affected, leading to a substantial economic loss. Using information fusion based on the Dezer-Smarandache theory, self-recursive wavelet neural network and unscented kalman filter, a novel method for online prediction of contamination is developed. All state variables of culture process involving easy-to-measure and difficult-to-measure variables commonly obtained with soft-sensors present their contamination symptoms. By extracting and fusing latent information from the changing trend of each variable, integral and accurate prediction results for contamination can be achieved. This makes preventive and corrective measures be taken promptly. The field experimental results show that the method can be used to detect the contamination in time, reducing production loss and enhancing economic efficiency.

show abstract

Section: Introductionmentioning

confidence: 99%

Online prediction for contamination of chlortetracycline fermentation based on Dezert–Smarandache theory

Yang

Chen

Jin

2015

Chinese Journal of Chemical Engineering

View full text Add to dashboard Cite

show abstract

Regulation of biosynthesis of secondary metabolites. I. Biosynthesis of chlortetracycline and tricarboxylic acid cycle activity

Hošťálek

Tintérová

Jechová

et al. 1969

Biotech & Bioengineering

View full text Add to dashboard Cite

In the course of submerged cultivation of low-production and industrial production strains of Streptomyces aureofaciens, the activity of enzymes of the tricarboxylic acid cycle was studied. The activities of citrate synthase (EC 4.1.3.7), aconitate hydratase (EC 4.2.1.3), isocitrate dehydrogenase (EC 1.1.1.42), fumarate hydratase (EC 4.2.1.2), and malate dehydrogenase (EC 1.1.1.37) were estimated spectrophotometrically in cell-free preparations. In the growth phase, mainly the initial reactions of the cycle were active with both strains. In production-phase, the activities of enzymes in the low-production strain were 2-5 x higher than in the production strain. Benzylthiocyanate, a t a concentration of 5 x 10-5M, stimulated chlortetracycline production of both strains with accompanying decrease in activity of the enzymes of the tricarboxylic acid cycle. The role of the tricarboxylic acid cycle in control of chlortetracycline biosynthesis is discussed.

show abstract

Tetracyclin‐Produktion in einem Blasensäulenfermenter

Ross¹,

Schügerl

1988

Chemie Ingenieur Technik

View full text Add to dashboard Cite

Relationship between the carbohydrate metabolism ofStreptomyces aureofaciens and the biosynthesis of chlortetracycline

Cited by 20 publications

References 6 publications

Online prediction for contamination of chlortetracycline fermentation based on Dezert–Smarandache theory

Online prediction for contamination of chlortetracycline fermentation based on Dezert–Smarandache theory

Regulation of biosynthesis of secondary metabolites. I. Biosynthesis of chlortetracycline and tricarboxylic acid cycle activity

Tetracyclin‐Produktion in einem Blasensäulenfermenter

Contact Info

Product

Resources

About