Background:The conventional method of complete denture fabrication has many problems that include lack of uniform distribution of occlusal forces to the basal seat, causing inflammation, ulcers in the supporting tissues, more rapid residual ridge resorption, increase patient discomfort, increase parafunctional movements, and the need for frequent adjustments. Aim: The aim of this study is to evaluate and compare the effect of two different fabrication techniques for complete over dentures supported by mandibular implants. Methodology: A total of 24 edentulous subjects were eligible for inclusion. Using a random sampling system, conventional or Schlosser's technique was used to fabricate the dentures. Two implants were placed in the canine area of all patients. After 3 months, ball attachments were connected to the implants, and the denture delivered with the retentive components incorporated in the denture base. At the follow-up examinations, implant stability and marginal bone loss were evaluated at 3, 6, and 12 months. Results: The sample of 24 patients, with a mean age of 55.2 years, was included in this study. All patients attended the 12-month follow-up. The complete denture fabricated by Schlosser's technique showed significant more implant stability and less bone loss when compared to conventionally fabricated dentures. Conclusion: The Schlosser's technique is considered as predictable methods of complete denture construction. Consequently, this technique has a positive effect on the implants that supported mandibular overdenture. The more harmonious occlusion result from this technique results in better implant stability and decreases the rate of bone loss around the implants. Clinical Significance: The denture fabricated with Schlosser's technique results in more harmonious occlusion that suggested as one requirement of successful dental implants.