Relationship between the aggregation of nanoparticles bearing zinc ions and cytotoxicity and morphology of blood cells

Орлова, М. А.; Osipova, E. Yu.; Румянцев, С. А.; Zaitsev, Dmitry A.

doi:10.1007/s11172-013-0152-8

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…According to defined exclusion criteria, 2410 studies were excluded through abstract/title screening. One hundred and fifty two studies for treatment and detection were considered for the full-text evaluation, and 54 studies were also excluded because of not satisfying the inclusion criteria, using other cell lines instead of humane ALL ( n = 5), 34–38 not being totally relevant to our objective, or lacking detailed and obvious data ( n = 23 for treatment; 39–61 n = 14 for detection) 20,62–74 and not having full-text publications available ( n = 12). 64,75–85 Finally, 63 articles matched the inclusion criteria for the treatment section ( n = 63) and 35 articles for the detection section ( n = 35).…”

Section: Resultsmentioning

confidence: 99%

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

et al. 2023

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The magnetic isotope effect as a tool for apoptosis modulation in leukemic cells

Орлова

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Орлов

2014

Moscow Univ. Chem. Bull.

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The magnetic isotope effect (MIE) was discovered for isotopes of carbon as a relationship between the reaction rate (or probability of molecule formation) and nuclear spin, its projection, magnetic moment, and energy of electron nuclear (superfine) interaction [1]. MIE leads to isotope fractionation in dependence on their magnetic moment. This effect was later discovered [2] to occur for many pairs and triads of isotopes:Abstract-Lymphocytes from healthy donors and leukemic cells of patients with acute B lymphoblastic leu kemia (BALL 1) and acute myeloid leukemia were exposed to nanoparticles bearing magnetic (Zn 67) and nonmagnetic (total isotope pool) nuclei of zinc. The values of the corresponding magnetic isotope effects determined as the ratio of LD 50 magnitudes of preparations with magnetic and nonmagnetic zinc isotopes were 0, 3.5, and 1.5. Morphological studies using confocal and fluorescence microscopy showed apoptotic death of cells with the preparations; as well, there was an increase in the cell aggregation and better aggrega tion of nanoparticles in the case of 67 Zn NP, which resulted in a decrease of cytotoxicity. However the mag netic isotope effect was observed even in the case of aggregation.

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Relationship between the aggregation of nanoparticles bearing zinc ions and cytotoxicity and morphology of blood cells

Cited by 2 publications

References 9 publications

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

The magnetic isotope effect as a tool for apoptosis modulation in leukemic cells

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