Relationship between the acid-induced cough response and airway responsiveness and obstruction in children with asthma.

Shimizu, Toshio; Mochizuki, Hiroyuki; Tokuyama, Kenichi; Morikawa, Akihiro

doi:10.1136/thx.51.3.284

Cited by 22 publications

(7 citation statements)

References 23 publications

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“…18,24 Increased cough-receptor sensitivity has been associated with persistent cough, 25 but not with asthma. 26 Similarly, our results indicate that children with cough and obvious BHR usually develop asthma, while those with less BHR do not. We conclude that there are two types of chronic cough: one type of cough in patients with obvious BHR who develop asthma, and another type of cough in patients with less BHR who do not develop asthma.…”

Section: Discussionsupporting

confidence: 72%

Relationship between bronchial hyperresponsiveness and development of asthma in children with chronic cough

Nishimura

Mochizuki

Tokuyama

et al. 2001

Pediatric Pulmonology

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To evaluate the relationship between bronchial hyperresponsiveness (BHR) and the development of asthma in children with chronic cough, we performed methacholine inhalation challenges and transcutaneous oxygen pressure (tcPO2) measurements in 92 children with chronic cough aged from 1-13 years (55 boys and 37 girls; mean, 5.3 years) and followed them for > or = 10 years. Forty-four age-matched children with asthma (24 males and 20 females; mean, 6.5 years) and 44 age-matched children without cough or asthma served as controls (18 males and 26 females; mean, 4.6 years). Consecutive doubling doses of methacholine were inhaled until a 10% decrease in tcPO2 from baseline was observed. The cumulative dose of methacholine at the inflection point of the tcPO2 record (Dmin-PO2) was considered to represent hyperresponsiveness to inhaled methacholine. After 10 years or more of follow-up, 60 of the 92 subjects with cough answered our questionnaire, and 27/60 had been diagnosed with asthma. There was a statistical difference in Dmin-PO2 between the children who presented with chronic cough originally and who developed asthma (asthma-developed group) and those who did not develop asthma (asthma-free group). There was no difference in the value of Dmin-PO2 between the asthma-developed group and the asthma group, or between the asthma-free group and the age-matched control group. Among the children with chronic cough, there was no difference in Dmin-PO2 between girls and boys, either in the asthma-developed group or in the asthma-group. We conclude that 45% of the children with a chronic cough in early life developed asthma, and that BHR in children with chronic cough during the childhood period is a strong risk factor for the development of asthma.

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Section: Discussionsupporting

confidence: 72%

Relationship between bronchial hyperresponsiveness and development of asthma in children with chronic cough

Nishimura

Mochizuki

Tokuyama

et al. 2001

Pediatric Pulmonology

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“…The relation between the change in FEV 1 and the corresponding change in cough sensitivity is not evaluated in this paper, and we suspect that for individuals there is no relation between these variables. Using paired analysis, several groups have shown the independence of cough receptor sensitivity and bronchomotor tone in the laboratory in children17 and adults 1819 We have also found that in children with asthma recovering from an acute exacerbation, there is no relation between cough sensitivity and FEV 1 20.…”

Section: Discussionmentioning

confidence: 74%

Cough sensitivity in children with asthma, recurrent cough, and cystic fibrosis

Chang

Phelan

et al. 1997

Archives of Disease in Childhood

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In adults, cough sensitivity is influenced by gender and is heightened in those with non-productive cough. This study examined if cough sensitivity is (i) altered in children with asthma, recurrent cough, and cystic fibrosis and (ii) influenced by age, gender, or forced expiratory volume in one second (FEV 1 ).Cough sensitivity to capsaicin and spirometry were performed on 209 children grouped by the diagnosis of asthma, recurrent dry cough, cystic fibrosis, and controls.Cough sensitivity was increased in children with recurrent cough, and lower in children with cystic fibrosis when compared with children with asthma and controls. Age influenced cough sensitivity in the controls. In the asthmatics, FEV 1 (% predicted) correlated to cough sensitivity measures. There was no gender diVerence in cough sensitivity.It is concluded that cough sensitivity is diVerent among children with recurrent dry cough, asthma, and cystic fibrosis. In children, age, but not gender, influences cough sensitivity measures and when cough sensitivity is used in comparative studies, children should be matched for age and FEV 1 .

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“…However, accumulating data indicate that cough and bronchoconstriction are separate airway reflexes. We have reported that inhaled acid can elicit cough without bronchoconstriction [15], and that airway obstruction does not change the acid-induced cough threshold in children with asthma [29]. The absence of permeant anion (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effect of influenza A virus infection on acid-induced cough response in children with asthma

Shimizu¹,

Mochizuki²,

Morikawa³

1997

Eur Respir J

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Although it is well-known that some types of respiratory viral infections cause airway hyperresponsiveness in humans, the effect of viral infection on the cough threshold in asthmatics is not known. We, therefore, evaluated the effects of naturally-acquired influenza A virus infection on the cough threshold to inhaled acid in children with asthma.Twelve children with asthma (9 boys and 3 girls, mean±SEM age of 10.8±0.6 yrs), who had naturally-acquired influenza A virus infection in winter (January-February, 1992) during an epidemic of influenza A (H 1 N 1 ), were enrolled in this prospective, uncontrolled study. All patients underwent acetic acid (AA) inhalation challenge 2, 4 and 6 weeks after the influenza infection.The cough threshold values (the lowest concentrations of AA eliciting coughs) after 2, 4 and 6 weeks of the illness were 3.7±0.9, 5.3±1.0 and 8.1±1.4% (mean±SEM), respectively. Cough threshold values 4 or 6 weeks after the illness improved significantly over that at 2 weeks (p<0.05 and p<0.01, respectively). In contrast, baseline forced expiratory volume in one second did not change throughout the study.These results indicate that influenza A virus infection attenuates the cough threshold independently of airway obstruction in children with asthma. The enhanced cough response following virus infection is probably mediated by damage to the airways epithelium.

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Relationship between the acid-induced cough response and airway responsiveness and obstruction in children with asthma.

Abstract: Background -In children with asthma

Cited by 22 publications

References 23 publications

Relationship between bronchial hyperresponsiveness and development of asthma in children with chronic cough

Relationship between bronchial hyperresponsiveness and development of asthma in children with chronic cough

Cough sensitivity in children with asthma, recurrent cough, and cystic fibrosis

Effect of influenza A virus infection on acid-induced cough response in children with asthma

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