Relationship between temporal sequence of right ventricular deformation and right ventricular performance in patients with corrected tetralogy of Fallot

Hulst, Annelies E. van der; Roest, Arno A.W.; Delgado, Victoria; Holman, Eduard R.; Roos, Albert de; Blom, Nico A.; Bax, Jeroen J.

doi:10.1136/hrt.2010.199919

Cited by 24 publications

(32 citation statements)

References 32 publications

(27 reference statements)

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“…Fernandes et al 23 did not identify a significant difference in dyssynchrony parameters in children and adolescents with repaired TOF compared with controls. Van der Hulst et al, 24 however, have reported a delay in activation of the RV outlet in repaired pediatric patients with TOF, compared with normal controls. In our work, the TOF case (adverse outcome) group was not found to be significantly more dyssynchronous than the TOF control group, for any of the parameters investigated.…”

Section: Discussionmentioning

confidence: 96%

Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia

Moon

Choueiter

Geva

et al. 2015

The American Journal of Cardiology

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Section: Discussionmentioning

confidence: 96%

Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia

Moon

Choueiter

Geva

et al. 2015

The American Journal of Cardiology

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“…Clinical applications of strain imaging to assess systolic and diastolic function in children with a variety of complex conditions (congenital heart disease, cystic fibrosis, sickle-cell anemia, and chronic lung disease) have recently reported measures of global and segmental longitudinal strain and strain rate. (12–24). However, the mean values and associated variations of these strain values need to be firmly established before routine clinical adoption of RV strain measurements can be implemented in children (11).…”

Section: Introductionmentioning

confidence: 99%

Normal Ranges of Right Ventricular Systolic and Diastolic Strain Measures in Children: A Systematic Review and Meta-Analysis

Levy

Mejia

Machefsky

et al. 2014

Journal of the American Society of Echocardiography

143

108

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Background Establishment of the range of normal values and associated variations of two-dimensional speckle-tracking echocardiography (2DSTE) derived right ventricular (RV) strain is a prerequisite for its routine clinical application in children. The objectives of this study were to perform a meta-analysis of normal ranges of RV longitudinal strain measurements derived by 2DSTE in children and identify confounders that may contribute to differences in reported measures. Methods A systematic review was launched in PubMed, Embase, Scopus, Cochrane, and ClinicTrials.gov. Search hedges were created to cover the concepts of pediatrics, speckle-tracking echocardiography, and right heart ventricle. Two investigators independently identified and included studies if they reported the 2DSTE derived RV strain measures: RV peak global longitudinal strain (pGLS), systolic strain rate (pGLSRs), early diastolic strain rate (pGLSRe), late diastolic strain rate (pGLSRa), or segmental longitudinal strain at the apical, mid, and basal ventricular levels in healthy children. Quality and reporting of the studies were assessed. The weighted mean was estimated by using random-effects with 95% confidence intervals (CI), heterogeneity was assessed by the Cochran's Q statistic and the inconsistency index (I2), and publication bias was evaluated using funnel plots and the Egger test. Effects of demographic, clinical, equipment, and software variables were assessed in a meta-regression. Results The search identified 226 children from 10 studies. The reported normal mean values of pGLS among the studies varied from −20.80% to −34.10% (mean, −29.03%, 95%CI, −31.52% to −26.54%), pGLSRs varied from −1.30 to −2.40 1/sec (mean, −1.88, 95%CI, −2.10 to −1.59), pGLSRe ranged from 1.7 to 2.69 1/sec (mean, 2.34, 95%CI, 2.00 to 2.67) and pGLSRa ranged from 1.00 to 1.30 1/sec (mean, 1.18, 95% CI, 1.04 to 1.33). A significant base-to-apex segmental strain gradient (p <0.05) was observed in the right ventricular free wall. There was significant between-study heterogeneity and inconsistency (I2>88% and p<0.01 for each strain measure), which was not explained by age, gender, body surface area, heart rate, frame rate, tissue tracking methodology, equipment, or software. The meta-regression showed that these effects were not significant determinants of variations among normal ranges of strain values. There was no evidence of publication bias (Egger test, p=0.59). Conclusions This study is the first to define normal values of two-dimensional speckle tracking echocardiographic (2DSTE) derived right ventricle strain in children on the basis of a meta-analysis. The normal mean value in children for RV global strain is −29.03% (95% CI, −31.52% to −26.54%). The normal mean value for RV global systolic strain rate is −1.88 1/sec (95% CI, −2.10 to −1.59). RV segmental strain has a stable base-to-apex gradient that highlights the dominance of deep longitudinal layers of the RV that are aligned base to apex. Variations among different normal ranges do not appe...

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“…Chronic exposure of the right ventricle (RV) to a regurgitant load may lead to progressive RV dilatation, and has been associated with adverse events such as increased symptoms, arrhythmia and death 2–6. Potential causes of RV dysfunction in adults with repaired TOF include abnormalities of the temporal pattern of RV mechanical activation 7. Although pulmonary valve replacement (PVR) is an effective way of reducing the volume load on the RV, there is no proof from prospective studies that it reduces the risk for adverse outcomes, such as sudden cardiac death, sustained ventricular arrhythmias or heart failure 8–13.…”

Section: Introductionmentioning

confidence: 99%

Exercise capacity and stroke volume are preserved late after tetralogy repair, despite severe right ventricular dilatation

O’Meagher

Munoz

Alison

et al. 2012

Heart

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Relationship between temporal sequence of right ventricular deformation and right ventricular performance in patients with corrected tetralogy of Fallot

Abstract: In patients with cToF, RV outlet deformation is delayed, causing a reduction in RV time delay which is significantly related to impairment in RV performance.

Cited by 24 publications

References 32 publications

Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia

Relation of Biventricular Strain and Dyssynchrony in Repaired Tetralogy of Fallot Measured by Cardiac Magnetic Resonance to Death and Sustained Ventricular Tachycardia

Normal Ranges of Right Ventricular Systolic and Diastolic Strain Measures in Children: A Systematic Review and Meta-Analysis

Exercise capacity and stroke volume are preserved late after tetralogy repair, despite severe right ventricular dilatation

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