Relationship between systemic inflammation and lung injury induced by chromate exposure: A cross–sectional study in workers

Zhang, Yali; Hong, Shiyi; Zhang, Qiaojian; Su, Zekang; Hu, Guiping; Wang, Tiancheng; Yu, Shanfa; Yuan, Fang; Zhu, Xiaojun; Jia, Guang

doi:10.1016/j.jhazmat.2023.131294

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…A human study observed an increase in the serum cytokines TNF-α and CXCL5 and a decrease in IL-10 after exposure to Cr(VI). Our previous research found an increase in e serum cytokines IL-1β, IL-23, and IFN-γ in a Cr(VI)-exposed population and observed a relationship between IFN-γ and lung injury . In a skin hypersensitivity experiment with mice exposed to potassium dichromate, percutaneous exposure resulted in changes in lymphocyte subpopulations in draining lymph nodes and peripheral blood.…”

Section: Resultsmentioning

confidence: 94%

“…Our previous research found an increase in e serum cytokines IL-1β, IL-23, and IFN-γ in a Cr(VI)-exposed population and observed a relationship between IFN-γ and lung injury. 47 In a skin hypersensitivity experiment with mice exposed to potassium dichromate, percutaneous exposure resulted in changes in lymphocyte subpopulations in draining lymph nodes and peripheral blood. Within the draining lymph nodes, the proportions of CD4+ T cells, CD8+ T cells, and T lymphocytes exhibited a dosedependent decrease with chromium salt exposure levels, while B lymphocytes significantly increased.…”

Section: Association Between Blood Cr and Geneticmentioning

confidence: 99%

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Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Su,

Zhang,

Hong

et al. 2024

Environ. Sci. Technol.

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Exposure to hexavalent chromium damages genetic materials like DNA and chromosomes, further elevating cancer risk, yet research rarely focuses on related immunological mechanisms, which play an important role in the occurrence and development of cancer. We investigated the association between blood chromium (Cr) levels and genetic damage biomarkers as well as the immune regulatory mechanism involved, such as costimulatory molecules, in 120 workers exposed to chromates. Higher blood Cr levels were linearly correlated with higher genetic damage, reflected by urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and blood micronucleus frequency (MNF). Exploratory factor analysis revealed that both positive and negative immune regulation patterns were positively associated with blood Cr. Specifically, higher levels of programmed cell death protein 1 (PD-1; mediated proportion: 4.12%), programmed cell death ligand 1 (PD-L1; 5.22%), lymphocyte activation gene 3 (LAG-3; 2.11%), and their constitutive positive immune regulation pattern (5.86%) indirectly positively influenced the relationship between blood Cr and urinary 8-OHdG. NOD-like receptor family pyrin domain containing 3 (NLRP3) positively affected the association between blood Cr levels and inflammatory immunity. This study, using machine learning, investigated immune regulation and its potential role in chromate-induced genetic damage, providing insights into complex relationships and emphasizing the need for further research.

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Section: Resultsmentioning

confidence: 94%

Section: Association Between Blood Cr and Geneticmentioning

confidence: 99%

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Su,

Zhang,

Hong

et al. 2024

Environ. Sci. Technol.

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“…The improved DNA purity and reduced plasma concentrations following treatment using plant extracts could be attributed to the phytochemicals and phytonutrients in the plants. A phytoconstituent analysis of the examined vegetables revealed the presence of numerous vitamins and minerals (Yahaya et al 2017 There was evidence of lung inflammation, injury, and proliferative responses in rats that were repeatedly exposed to hexavalent chromium (Feary et al 2020, Zhang et al 2023. Acute and chronic lead exposure have been demonstrated to cause lung damage.…”

Section: Discussionmentioning

confidence: 99%

Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust

Yahaya,

Salisu,

Musa

et al. 2023

FMI

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Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, followed by the extracts of Z. officinale, M. oleifera, T. occidentalis, and H. sabdariffa, respectively. These findings suggested that the selected vegetables and spices have the properties to ameliorate the effects of cement dust exposure. Therefore, individuals residing in close proximity to cement plants are encouraged to consume these vegetables and spices.

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Cellular senescence mediates hexavalent chromium-associated lung function decline: Insights from a structural equation Model

Zhang,

Hu,

Zhang

et al. 2024

Environmental Pollution

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Relationship between systemic inflammation and lung injury induced by chromate exposure: A cross–sectional study in workers

Cited by 4 publications

References 34 publications

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust

Cellular senescence mediates hexavalent chromium-associated lung function decline: Insights from a structural equation Model

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