Relationship between subcutaneous fatness and leptin in male athletes

Sudi, Karl; Jürimäe, Jaak; Payerl, Doris; Pihl, Eve; Möller, Reinhard; Tafeit, Erwin; Jürimäe, Toivo

doi:10.1097/00005768-200108000-00013

Cited by 14 publications

(14 citation statements)

References 22 publications

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“…Although significant changes in fat percentage were detected in this study, the subjects actually had quite a low absolute body fat mass (i.e., less than 2.0 kg) and low plasma leptin concentrations. Previous reports also suggested that the typical characteristics of male endurance runners are low body fat mass and a low blood leptin level (Hickey et al, 1996;Sudi et al, 2001). In contrast, it is known that body fat mass is closely related to plasma leptin concentration in non-athletes Koistinen et al, 1998).…”

Section: Discussionmentioning

confidence: 98%

Plasma Leptin Levels of Elite Endurance Runners after Heavy Endurance Training

Ishigaki

Koyama

Tsujita

et al. 2005

J. Physiol. Anthropol.

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A decrease in testosterone levels and an increase in cortisol levels are observed in male athletes with the overtraining syndrome (OTS). Cortisol causes blood leptin levels to rise and testosterone has an inverse relationship with blood leptin levels. Therefore, we hypothesized that the hormonal changes as a result of OTS induce an increase in leptin. To test this hypothesis, we examined the relationship among changes in leptin, testosterone and cortisol in thirteen male collegiate distance runners (aged 20.3Ϯ1.1 years) before and after an 8-day strenuous training camp. Runners ran 284.1Ϯ48.2 km during the training camp. Body fat percentages and plasma glucose concentrations decreased significantly after the training. Non-ester fatty acids and total cholesterol concentrations in blood were unchanged. Serum cortisol concentrations showed a significant increase after the training camp (from 11.82Ϯ2.00 mg/dl to 16.78Ϯ3.99 mg/dl), and serum testosterone decreased significantly (from 408.0Ϯ127.6 ng/dl to 265.2Ϯ97.6 ng/dl). The ratio of testosterone to cortisol (TCR) dropped by 50% after training (from 35.62Ϯ13.69 to 16.94Ϯ8.47). These results suggest that the subjects reached a state of the OTS. Contrary to our hypothesis, plasma leptin was not significantly changed (from 1.34Ϯ0.29 ng/ml to 1.49Ϯ0.18 ng/ml). D Plasma leptin was not significantly correlated with D serum cortisol, D TCR or D fat percentage. However, D serum testosterone was positively correlated with D plasma leptin (rϭ596, pϽ0.05). Plasma leptin concentrations might modulate the secretion of testosterone in overtraining conditions. In conclusion, the change in blood leptin level is independent of the changes in cortisol, TCR and fat percentage in highly trained male athletes in the state of the OTS.

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Section: Discussionmentioning

confidence: 98%

Plasma Leptin Levels of Elite Endurance Runners after Heavy Endurance Training

Ishigaki

Koyama

Tsujita

et al. 2005

J. Physiol. Anthropol.

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“…Uma falha na sua produção e/ou na sua ação sobre os receptores hipotalâmicos poderia desequilibrar positivamente o balanço energético, gerando o quadro de obesidade (12). No entanto, estudos realizados em humanos mostram que os níveis plasmáticos de leptina são elevados em obesos quando comparados com seus congêneres magros (16,(33)(34)(35). Crianças pré-púberes e adolescentes obesos também apresentam níveis de leptina mais elevados do que indivíduos magros da mesma faixa etária (36).…”

Section: Mecanismos De Ação Da Leptina Na Ingestão Alimentarunclassified

Leptina, ghrelina e exercício físico

Mota

Zanesco

2007

Arq Bras Endocrinol Metab

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RESUMOA obesidade é atualmente um problema de saúde pública que provoca sérias conseqüências sociais, físicas e psicológicas. A etiologia da obesidade não é de fácil identificação, uma vez que a mesma é caracterizada como doença multifatorial de complexa interação entre fatores comportamentais, culturais, genéticos, fisiológicos e psicológicos. Recentes avanços na área de endocrinologia e metabolismo mostram que, diferentemente do que se acreditava há alguns anos, o adipócito sintetiza e libera diversas substâncias, não sendo apenas uma célula armazenadora de energia. Entre as substâncias liberadas pelo adipócito incluem-se a adiponectina, o fator de necrose tumoral-α, a interleucina-6 e a leptina. Especificamente, a leptina desempenha importante papel no controle da ingestão alimentar e no controle do peso corporal em mamíferos. Além disso, o hormônio ghrelina, recentemente descoberto, também parece influenciar o metabolismo energético e a obesidade. As alterações que o exercício físico provoca na fisiologia endócrino-metabólica podem contribuir sobremaneira para a prática clínica. Assim, essa revisão abordará os conhecimentos mais recentes sobre a leptina, a ghrelina e o papel dos diferentes tipos de exercício físico sobre estes hormônios. Os trabalhos mostram que a relação entre o exercício físico e a concentração plasmática desses peptídeos ainda não está clara. As razões para isso poderiam ser devidas aos diferentes protocolos de treinamento físico empregados nos estudos. Além disso, diferenças genéticas também podem explicar as discrepâncias entre os resultados obtidos em seres humanos, pois a existência de polimorfismo em alguns genes pode acarretar respostas celulares diferentes frente ao exercício físico. Obesity is a major public health problem in the Western world resulting in serious social, physical and psychological damages. The genesis of obesity is complex involving a variety of factors such as genetic, psychological, metabolic and environmental factors. Progress in endocrinology and metabolism show that adipocyte is considered now as an endocrine tissue producing several substance including adiponectin, tumor necrosis factor-α, interleukin-6 and leptin. Specifically, leptin is the main peptide produced by the adipocyte and its serum concentration represents an important peripheral signal in the regulation of food intake and energy expenditure in mammals. In addition to leptin, a new peptide was discovered recently named ghrelin. Ghrelin, a peptide hormone identified in the stomach, is directly involved with the regulation of energy balance and obesity. Physical exercise has been used as a non-pharmacological tool in management of body weight and the effect of physical activity on weight control is an important issue for clinical studies in endocrinology field. Thus, this review will attempt to update the knowledge of leptin and ghrelin on the body weight regulation and the effect of exercise training on these peptide concentrations. It can be concluded that the relationship between physical exer...

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“…In humans, the systemic leptin level has been reported to be proportional to the body fat mass [2, 3]. In trained subjects, the circulating leptin level is low, and even at biologically extremely low levels of body fat, the leptin concentration is closely related to the body fat content in male athletes [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

“…An exercise-mediated negative energy balance may contribute to the regulation of plasma leptin levels and presumably leptin action [3, 4]. Furthermore, it has recently been suggested that the regulation of leptin may also depend on factors at the metabolic level associated with certain long-term exercise regimens [4].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Heavy Increase in Training Stress on the Plasma Leptin Concentration in Highly Trained Male Rowers

Mäestu¹,

Jürimäe²,

Jürimäe³

2003

Horm Res Paediatr

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Aim: To characterize the effects of a heavy increase in training stress followed by a reduced stress on fasting plasma leptin levels in highly trained male rowers. Methods: 12 rowers underwent a 3-week period of maximally increased training stress followed by a 2-week tapering period. Results: A mean 22% increase in training stress caused a significant decrease (by 8%) in the leptin concentrations. A further increase in training stress by 25% significantly reduced leptin further by 35%. A 1st tapering week, during which the training stress was rapidly reduced by approximately 50%, significantly increased the plasma leptin concentrations by 29%. Plasma leptin was significantly increased further (by 4%) during the 2nd tapering week. Conclusion: Leptin is sensitive to pronounced changes in training stress in highly trained male rowers.

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Relationship between subcutaneous fatness and leptin in male athletes

Cited by 14 publications

References 22 publications

Plasma Leptin Levels of Elite Endurance Runners after Heavy Endurance Training

Plasma Leptin Levels of Elite Endurance Runners after Heavy Endurance Training

Leptina, ghrelina e exercício físico

Effect of Heavy Increase in Training Stress on the Plasma Leptin Concentration in Highly Trained Male Rowers

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