Relationship between stress and coronary heart disease

Kurd, Bushra Jawaid; Dar, Mudassir Iqbal; Shoaib, Maria; Malik, Laraib; Aijaz, Zobia; Asif, Iqra

doi:10.1177/0218492312469803

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…CHD has become the most common disease and the leading cause of death around the world [15]. It is well known that atherosclerosis is the main pathological basis of CHD.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease

Zhang

Cai

et al. 2020

Med Princ Pract

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Background: Kallistatin and ENOX1 are regulators of inflammation and oxidative stress which are typical pathological reactions in atherosclerosis. However, there is limited information of kallistatin and ENOX1 in coronary heart disease (CHD). Methods: Fifty healthy controls, 56 stable angina pectoris (SAP) patients, and 47 acute coronary syndrome (ACS) patients were included in this study. Levels of kallistatin and ENOX1 in serum were measured by ELISA. χ2 test was performed to analyze categorical data. ANOVA, Pearson correlation analysis, and multiple linear regression were performed to analyze the numerical data. Finally, receiver operating characteristic (ROC) curve was applied to assess the diagnostic value of kallistatin in CHD. Results: Among the 153 participants, 59.5% were male and the average age was 63.8 ± 11.39 years. Compared with the control group, kallistatin expression was decreased in the SAP and ACS groups while expression of ENOX1 was increased in the ACS group (p < 0.05). Pearson correlation analysis showed that the kallistatin level was negatively correlated with the Gensini score (r = −0.210, p < 0.01), white blood cell (WBC) count (r = −0.283, p < 0.001), and triglyceride levels (r = −0.242, p < 0.01) and positively correlated with age (r = 0.353, p < 0.001) and high-density lipoprotein cholesterol (r = 0.310, p < 0.001). ENOX1 expression was positively correlated with WBC count (r = 0.244, p < 0.01), international normalized ratio (r = 0.177, p < 0.05), and Gensini score (r = 0.201, p < 0.05). Multiple linear regression showed that Cr, alanine transaminase, glucose, and kallistatin are independent predictors for Gensini score. The ROC curve showed that kallistatin had the highest diagnostic significance (p = 0.007) when the area under curve was 0.636, with a sensitivity of 0.735 and a specificity of 0.495. Conclusion: Expression of kallistatin was decreased in CHD patients and that of ENOX1 was increased in ACS patients. Kallistatin and ENOX1 were closely connected with the severity of CHD, and kallistatin may be helpful in the diagnosis of CHD.

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“…CHD has become the most common disease and the leading cause of death around the world [15]. It is well known that atherosclerosis is the main pathological basis of CHD.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease

Zhang

Cai

et al. 2020

Med Princ Pract

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“…This finding is consistent with previous studies. 19,20-22 More than 96% of coronary patients suffer from moderate to severe stress. 19 in addition, prior cardiac disease, lifestyle components such as physical inactivity, smoking, alcohol drinking, abnormal BMI have an important role in increased risk of CVDs.…”

Section: Discussionmentioning

confidence: 99%

“…19,20-22 More than 96% of coronary patients suffer from moderate to severe stress. 19 in addition, prior cardiac disease, lifestyle components such as physical inactivity, smoking, alcohol drinking, abnormal BMI have an important role in increased risk of CVDs. 20,21 Meanwhile, the results of a review study showed that bowel toxicity increases the risk of developing CVDs.…”

Section: Discussionmentioning

confidence: 99%

Role of perceived heart risk factors by outpatient population in predicting cardiovascular risk

Soroush

Shams-Alizadeh

Vahdat

et al. 2019

J Cardiovasc Thorac Res

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Introduction: Regarding the expanding population in developing countries who are at risk for cardiovascular diseases (CVDs), identification and management of effective factors are important in reducing the risk of CVDs. So, the present study aimed to assess the role of perceived heart risk factors (PHRFs) in the prediction of cardiovascular risk among outpatient patients. Methods: The samples of this cross-sectional study included 150 outpatient patients who attend the clinic of Imam Reza hospital during October-December 2016. The participants were completed the Perceived Heart Risk Factors Scale (PHRFS) and Cardiovascular Risk Assessment Questionnaire (CRAQ). Data analyzed through Pearson correlation and multiple regression analyses. Results: Based on the findings, 28%, 40%, 22.7%, and 9.3% of patients were low, medium, high, and severely high-risk, respectively. The strongest predictors of the cardiovascular risk were physiological (β = -0.273; P = 0.004), psychological (β=0.236; P = 0.020), and biological risk factors (β=0.209; P = 0.016), respectively. In addition, the strongest predictor of the lifestyle risk was physiological risk factors (β = -0.264; P = 0.007). Other variables do not play a significant role in predict the lifestyle risk (P > 0.05). Our model was able to explain 9.2% of cardiovascular risk variance and 5.7% of cardiovascular risk caused by lifestyle variance. Conclusion: The higher patients’ perception about biological and psychological risk factors is concerned as an alarm for increased cardiovascular risk while higher perception about physiological risk factors is associated with reduced cardiovascular risk caused by lifestyle and total cardiovascular risk. The programs reducing cardiovascular risk should target the high-risk groups to save cost and time.

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“…Research has shown that physical activity can help manage stress (Manger & Motta, 2005; Nabkasorn et al, 2006; P. Salmon, 2001), and studies have linked chronic stress with certain health problems such as decline in verbal learning and memory (Agbenyikey et al, 2015), digestive diseases (Lee et al, 2015), and heart disease (Kurd et al, 2014). It is unclear whether the comparatively lower level of agreement that physical activity is done to help manage stress is because stress is less common than a desire to feel mentally and physically good today and to relieve physical and mental decline in the future or because the link between chronic stress and related health consequences is less understood.…”

Section: Discussionmentioning

confidence: 99%

Identifying Chronic Conditions and Other Selected Factors That Motivate Physical Activity in World Senior Games Participants and the General Population

Merrill

Bowen

Hager

2015

Gerontology and Geriatric Medicine

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This study assesses chronic disease or disease-related conditions as motivators of physical activity. It also compares these and other motivators of physical activity between Senior Games participants (SGPs) and the general population. Analyses are based on an anonymous cross-sectional survey conducted among 666 SGPs and 177 individuals from the general population. SGPs experienced better general health and less obesity, diabetes, and depression, as well as an average of 14.7 more years of regular physical activity (p < .0001), 130.8 more minutes per week of aerobic activity (p < .0001), and 42.7 more minutes of anaerobic activity per week (p < .0001). Among those previously told they had diabetes, high blood pressure, high cholesterol, or depression, 74.2%, 72.2%, 70.4%, and 60.6%, respectively, said that it motivated them to increase their physical activity. Percentages were similar between SGPs and the general population. SGPs were more likely motivated to be physically active to improve physical and mental health in the present, to prevent physical and cognitive decline in the future, and to increase social opportunities. The Senior Games reinforces extrinsic motivators to positively influence intrinsic promoters such as skill development, satisfaction of learning, enjoyment, and fun.

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Relationship between stress and coronary heart disease

Abstract: Our study found evidence of an independent causative association between psychological stress and coronary heart disease, of a similar order to the more conventional coronary heart disease risk factors.

Cited by 11 publications

References 13 publications

Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease

Clinical Significance of Serum Kallistatin and ENOX1 Levels in Patients with Coronary Heart Disease

Role of perceived heart risk factors by outpatient population in predicting cardiovascular risk

Identifying Chronic Conditions and Other Selected Factors That Motivate Physical Activity in World Senior Games Participants and the General Population

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