Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women

Dozio, Elena; Briganti, Silvia; Delnevo, Alessandra; Vianello, Elena; Ermetici, Federica; Secchi, Francesco; Sardanelli, Francesco; Morricone, Lelio; Malavazos, Alexis Elias

doi:10.1007/s00394-016-1291-0

Cited by 40 publications

(35 citation statements)

References 48 publications

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“…Differently, in the DM CKD-G5D group, it reached pathological levels and it was statistically significantly higher than in the non-DM CKD-G5D patients ( p < 0.001) (Table 1 and Figure 1()). According to our previous results on sRAGE concentrations in healthy subjects (mean value 1363.0 ± 693.2 ng/mL) [36], sRAGE levels were above the normal values both in non-DM CKD-G5D and DM CKD-G5D patients and resulted statistically significantly higher in the DM CKD-G5D compared to the non-DM CKD-G5D group ( p < 0.05) (Table 1 and Figure 1()). cFGF-23 levels were higher than the reference value (<180 RU/mL), but we did not find any significant difference between groups (non-DM CKD-G5D: median value, 1345.00, 25th–75th percentiles (508.10–3087.00) RU/mL; DM CKD-G5D: 1707.00, (1183.00–4016.00 RU/mL) (Table 2 and Figure 1())).…”

Section: Resultsmentioning

confidence: 60%

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Dozio

Corradi

Vianello

et al. 2017

Mediators of Inflammation

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Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients. The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups. Only GA and sRAGE levels were increased in DM compared to non-DM patients. Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration. In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling. Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation. The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies.

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Section: Resultsmentioning

confidence: 60%

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Dozio

Corradi

Vianello

et al. 2017

Mediators of Inflammation

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“…Although majority of studies in subjects without diabetes (including pre-pubertal children and elderly subjects) report inverse relationship between measures of obesity and sRAGE levels (4,6-9), the data are equivocal (10,11). We did not confirm our hypothesis that this discrepancy might be on the account of MHO phenotype: COH and COU women who did not differ with regard to their measures of obesity displayed similar decline in sRAGE levels.…”

Section: Discussionmentioning

confidence: 99%

“…In large community-based population study in subjects without diabetes low levels of sRAGE were significantly associated with future risk of diabetes, coronary heart disease, and mortality (36). In healthy adult women lower sRAGE levels reflected accumulation of the epicardial visceral fat (9). Thus, low sRAGE levels associating with microinflammatory status suggest that despite an absence of standard cardiometabolic risk factors MHO women might be on increased risk to develop cardiometabolic disease in future.…”

Section: Discussionmentioning

confidence: 99%

“…While majority of studies in subjects without diabetes reported an inverse relationship between sRAGE and measures of adiposity (4,6-9), other studies revealed no significant association (10,11). We speculated whether this discrepancy in findings might be explained by obese metabolically healthy phenotype, ie, obese subjects without increased blood pressure, atherogenic lipid profile, and insulin resistance (12).…”

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confidence: 91%

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Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and activity of semicarbazide-sensitive amine oxidase

et al. 2017

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AimTo determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU).Methods47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included. Anthropometric characteristics, blood chemistry and hematology data, adipokines, markers of inflammation, sRAGE, soluble vascular adhesion protein-1 (sVAP-1), and the activity of semicarbazide sensitive amine oxidase (SSAO) were determined.ResultsCentral obesity associated with low sRAGE levels (lean healthy: 1503 ± 633 pg/mL; COH: 1103 ± 339 pg/mL, P < 0.05; COU: 1106 ± 367 ng/mL, P < 0.0.1), hyperleptinemia, and elevated markers of inflammation irrespective of the presence or absence of cardiometabolic risk factors. COU women presented high adiponectin levels. SVAP-1 concentrations and the activity of SSAO were similar in all 3 groups.ConclusionCOH women present abnormalities in non-standard markers of cardiometabolic risk (sRAGE, leptin, high sensitive C-reactive protein), supporting the view that there is no healthy pattern of obesity. The clinical impact of our findings for future prognosis of metabolically healthy obese subjects remains to be elucidated in longitudinal studies.

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“…Previous studies reported a connection between the levels of soluble AGE receptors [5] and fat tissue content, epicardial fat and impaired insulin action in the healthy population, in the population with prediabetes, and in patients with coronary artery disease [16,17]. Unoki et al [18] suggested that AGEs decrease glucose uptake by the adipocytes through the stimulation of intracellular reactive oxygen species production.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus

et al. 2019

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Aim To evaluate the association between skin advanced glycation end products and insulin resistance in Type 1 diabetes.Methods The study group consisted of 476 people with Type 1 diabetes (247 men) with a median (interquartile range) age of 42 (33-53) years, disease duration of 24 (19-32) years and HbA 1c concentration of 63 (55-74) mmol/mol [7.9 (7.2-8.9)%]. Insulin resistance was assessed according to estimated glucose disposal rate. Advanced glycation product accumulation in the skin was measured by autofluorescence using an AGE Reader. The group was divided into three subgroups based on estimated glucose disposal rate tertiles (<5.5, 5.5-9.5 and >9.5 mg/kg/min, respectively). The higher the estimated glucose disposal rate, the lower the insulin resistance.Results Skin autofluoresence level decreased with increasing estimated glucose disposal rate; comparing people below the lower tertile, with those between the first and third tertiles, and with those above the third tertile, the median autofluoresences were, respectively: 2.5 (2.2-2.9) vs 2.3 (2.0-2.7) vs 2.1 (1.9-2.5) AU (P<0.0001). A negative correlation was observed between skin autofluorescence and estimated glucose disposal rate (Spearman's correlation coefficient=-0.31, P <0.001). Multiple logistic regression showed a significant, two-way association of insulin resistance with skin autofluorescence.Conclusion The results of this study offer strong evidence for a two-way relationship between insulin resistance and advanced glycation product accumulation in the skin in people with Type 1 diabetes.

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Relationship between soluble receptor for advanced glycation end products (sRAGE), body composition and fat distribution in healthy women

Cited by 40 publications

References 48 publications

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and activity of semicarbazide-sensitive amine oxidase

Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus

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