Relationship between social function and personal recovery in patients with schizophrenia

Effect of Lurasidone on Social Functioning in Schizophrenia

“…10 The degree of impairment in social functioning in those with schizophrenia has been found to be associated with the extent to which personal recovery is achieved in such individuals. 11,12 For these reasons, improving social functioning is an important clinical outcome for patients with schizophrenia.…”

“…Considering the early deficits in social functioning associated with schizophrenia, and the relation of such deficits to the degree of achievement in personal recovery, improvement in social functioning should be a high priority in the clinical management of individuals with this disorder. 6,11,12 Noteworthy was the fact that improvements in social functioning continued through the open-label extension phase. The 26.7% additional mean change evident over the course of the 12-week open-label phase is particularly important because deficits in social functioning have been found to be highly persistent among those with schizophrenia over time periods as long as 20 years.…”

“…Two patients assigned to lurasidone and 2 assigned to placebo during the 6-week double-blind phase did not have post-baseline assessments, plus 1 patient (assigned to placebo) did not take any study medication, leaving 478 patients included in analyses of social functioning changes during the initial 6 weeks. Two patients enrolled in the extension phase did not have post-open-label baseline assessments (both treated with lurasidone 40 mg/d in the 6-week study) and were excluded from the analysis of changes in scores on the PANSS prosocial subscale during the 12 The demographic and clinical characteristics of the analysis sample for the 6-week study were generally similar for those who received lurasidone compared to placebo. The sample analyzed for the extension phase was also similar to those enrolled during the 6-week phase (Table 1).…”