Relationship between smoking status and periodontal conditions: findings from national databases in Japan

Ojima, Miki; Hanioka, Takashi; Tanaka, Keiko; Inoshita, Eiji; Aoyama, Hitoshi

doi:10.1111/j.1600-0765.2006.00915.x

Cited by 76 publications

(87 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cigarette smoking leads to deterioration of the periodontal condition in Japanese adults by analyses of the same databases used in the present study, though the effect would be underestimated due to the low power in detecting periodontal destruction. 32 Though the study population was derived from national databases, the results in terms of prevalence and distribution may not represent the national status. The source of the surveyed population in the NNS was based on the household.…”

Section: Malesmentioning

confidence: 99%

Relationship between smoking status and tooth loss: Findings from national databases in Japan

Hanioka

Ojima

Tanaka

et al. 2007

Journal of Epidemiology

View full text Add to dashboard Cite

Section: Malesmentioning

confidence: 99%

Relationship between smoking status and tooth loss: Findings from national databases in Japan

Hanioka

Ojima

Tanaka

et al. 2007

Journal of Epidemiology

View full text Add to dashboard Cite

“…This disparity may be due to differences in bacterial burden or the severity of periodontitis between genders. Epidemiological surveys showed a higher prevalence and greater extent of attachment loss (a clinical characteristic of periodontitis) in males than in females 30) . Clinical records of periodontitis were unavailable for evaluation in this study; however, the lower antibody titers in women in our study population may reflect the extent of severity of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Elevated Antibody Titers to Porphyromonas gingivalis as a Possible Predictor of Ischemic Vascular Disease

Tabeta

Tanabe

Yonezawa

et al. 2011

JAT

View full text Add to dashboard Cite

Aim: Limited epidemiological studies have investigated the relationship between ischemic vascular disease and periodontitis in non-Western populations. We investigated this relationship in a Japanese cohort by measuring serum titers of antibodies to periodontopathic bacteria. Methods: As part of the Tokamachi-Nakasato cohort study, we followed up 7021 participants regarding cardiovascular events over 5 years, and observed 99 ischemic vascular events: 66 cerebral infarctions and 33 cases of ischemic heart disease (IHD). For a nested case-control study, we selected 495 sex-and age-matched control subjects. Conditional logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) of ischemic vascular events associated with antibody titers to Porphyromonas gingivalis FDC381 and SU63. Multivariable models were adjusted for traditional cardiovascular risk factors using propensity scores. Results: The highest tertile category of antibody titers to P. gingivalis FDC381 in men was significantly associated with an increased risk of cerebral infarction in only the crude model. The 2nd and 3rd tertile categories of antibody titers to P. gingivalis SU63 were significantly associated with an increased risk of cerebral infarction in men (multivariable ORs (95% CIs) were 7.12 (1.51-33.5) and 9.03 (1.97-41.5), respectively). The association was not appreciably modified when we further adjusted for serum high-sensitivity C-reactive protein levels. Antibody titers to P. gingivalis were not dose-dependently associated with the risk of IHD. Conclusion: High serum antibody titers to P. gingivalis SU63 could be a predictor of cerebral infarction in Japanese men independent of traditional risk factors and inflammation. J Atheroscler Thromb, 2011; 18:808-817.

show abstract

“…Periodontitis is a common chronic dental disease worldwide, and based on a national survey, it is present in 42.5% of Japanese citizens (1,2). The onset of this disease results from bacterial plaque accumulation that elicits an inflammatory cascade, leading to leukocyte infiltration, connective tissue destruction, pocket formation, and alveolar bone resorption (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice

et al. 2017

View full text Add to dashboard Cite

Bone marrow-derived multipotent stromal cells (BMSCs) have potent antiinflammatory effects. This study aimed to investigate the antiinflammatory potential of BMSCs using a mouse model of ligatureinduced periodontitis. BMSCs were isolated from the femurs and tibiae of mice. Periodontitis was induced by placing a ligature around the right maxillary second molar. After 3 days, the mice were administered BMSC in the gingiva of the mesial interdental papilla around the ligatured molar. The ligatured and non-ligatured mice that were not administered BMSC served as controls. Differences in inflammatory infiltration and bone resorption around the roots of the second molar were assessed and were subsequently quantified using microcomputed tomography (micro-CT), histological analysis, and tartrate-resistant acid phosphatase (TRAP) staining. Micro-CT revealed that alveolar bone loss around the ligatured molars increased in a time-dependent manner; however, the effect was significantly less in BMSC-treated mice compared with ligatured control mice. Tissue histopathology revealed that BMSC administration mitigated inflammatory infiltration in ligatured BMSC mice. In addition, the number of TRAP-positive osteoclasts was markedly elevated in ligatured control mice compared with those in BMSC-treated mice. These findings indicate that local BMSC administration can mitigate inflammation and alveolar bone resorption, suggesting that administering BMSC leads to new therapeutics for periodontitis.

show abstract

Relationship between smoking status and periodontal conditions: findings from national databases in Japan

Abstract: Based on the findings of this study and other numerous reports, cigarette smoking leads to deterioration of periodontal conditions in Japanese adults.

Cited by 76 publications

References 33 publications

Relationship between smoking status and tooth loss: Findings from national databases in Japan

Relationship between smoking status and tooth loss: Findings from national databases in Japan

Elevated Antibody Titers to Porphyromonas gingivalis as a Possible Predictor of Ischemic Vascular Disease

Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice

Contact Info

Product

Resources

About