Relationship between sleep patterns and human colonic motor patterns

Furukawa, Yoshiyuki; Cook, Ian J.; Panagopoulos, Voula; Rd, McEvoy; Sharp, David J.; Simula, Maria Pina

doi:10.1016/0016-5085(94)90539-8

Cited by 104 publications

(87 citation statements)

References 28 publications

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“…This agrees with the previous observations in man and pig in which colonic motor activity decreased in the night (7,16,21,22). Pigs continued to sleep nearly the entire night in this experiment.…”

Section: Discussionsupporting

confidence: 83%

Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility.

Ohashi

Inoüe

Tanaka

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe aim of this study was to investigate the effect of probiotic, i.e., fermented milk prepared with Lactobacillus casei strain Shirota, on colonic motility by the strain gauge force transducer (SGFT) in a pig model. The contractions of the circular muscle layer of the cecum, upper colon, lower colon, and terminal colon in pigs were directly measured in con scious status by this method. This method was useful for quantitatively evaluating the ef fects of stimuli on colonic motility. Feeding significantly stimulated the motilities of the upper and lower colon. Defecation significantly stimulated the motilities of the upper and terminal colon. Two weeks' feeding of the fermented milk significantly activated the re sponse to feeding in four portions of the large intestine. It increased motility of the terminal colon that did not promote defecation. The frequency of defecation from 9:00 to 10:00 (the period just after the morning meal) increased significantly, but from 0:00 to 1:00 (the midnight period) it decreased as a result of the ingestion of fermented milk. Such effects of the fermented milk on motility of the terminal colon are discussed in relation to the move ment of digesta. The effects may relate to the stimulation of colonic fermentation as shown by a decrease in fecal pH.

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Section: Discussionsupporting

confidence: 83%

Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility.

Ohashi

Inoüe

Tanaka

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…A correlation between the depth of sleep and the level of suppression of colonic motor activity has been described in healthy subjects. Using colonic manometry and simultaneous polysomnography, Furukawa et al [38] showed a significant decrease in propagating and nonpropagating colonic motor activity during sleep in healthy volunteers. In line with these observations are findings by Auwerda et al [39], who demonstrated that sleep results in a reduction of rectal motor activity.…”

Section: Biologic Rhythms In Colonic Motilitymentioning

confidence: 98%

Biologic clocks and the gut

Hoogerwerf

2006

Curr Gastroenterol Rep

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The gastrointestinal tract displays biologic rhythms in basal gastric acid output, epithelial cell proliferation, gastrointestinal motility, and appetite regulation. Furthermore, the development of gastrointestinal complications after administration of aspirin and after chemo- and radiotherapy for metastatic colon cancer depends on the time of administration. Biologic rhythms are driven by so-called clock genes. Thus, it is conceivable that subsets of genes in the gastrointestinal tract are under clock gene control as well. The purpose of this article is to discuss basic concepts in the studies of biologic rhythms, to review examples of biologic rhythms in the gastrointestinal tract, and to discuss examples of gastrointestinal diseases in which alterations in biologic rhythms may play a pathogenetic role.

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“…Consequently, we questioned whether protein provision during sleep would be followed by proper dietary protein digestion and absorption kinetics, resulting in a substantial increase in plasma amino acid availability. Although data on gut function during sleep are scarce, it has been reported that human intestinal motility follows a circadian rhythm with reduced nocturnal activity (16,23,29). Therefore, we first need to determine whether dietary protein provision during sleep allows the digestive tract to function properly.…”

mentioning

confidence: 99%

Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men

Groen¹,

Peter²,

Pennings³

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

104

115

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The loss of skeletal muscle mass with aging has been attributed to an impaired muscle protein synthetic response to food intake. Therefore, nutritional strategies are targeted to modulate postprandial muscle protein accretion in the elderly. The purpose of this study was to assess the impact of protein administration during sleep on in vivo protein digestion and absorption kinetics and subsequent muscle protein synthesis rates in elderly men. Sixteen healthy elderly men were randomly assigned to an experiment during which they were administered a single bolus of intrinsically l-[1-(13)C]phenylalanine-labeled casein protein (PRO) or a placebo (PLA) during sleep. Continuous infusions with l-[ring-(2)H(5)]phenylalanine and l-[ring-(2)H(2)]tyrosine were applied to assess in vivo dietary protein digestion and absorption kinetics and subsequent muscle protein synthesis rates during sleep. We found that exogenous phenylalanine appearance rates increased following protein administration. The latter stimulated protein synthesis, resulting in a more positive overnight whole body protein balance (0.30 ± 0.1 vs. 11.8 ± 1.0 μmol phenylalanine·kg(-1)·h(-1) in PLA and PRO, respectively; P < 0.05). In agreement, overnight muscle protein fractional synthesis rates were much greater in the PRO experiment (0.045 ± 0.002 vs. 0.029 ± 0.002%/h, respectively; P < 0.05) and showed abundant incorporation of the amino acids ingested via the intrinsically labeled protein (0.058 ± 0.006%/h). This is the first study to show that dietary protein administration during sleep is followed by normal digestion and absorption kinetics, thereby stimulating overnight muscle protein synthesis. Dietary protein administration during sleep stimulates muscle protein synthesis and improves overnight whole body protein balance. These findings may provide a basis for novel interventional strategies to attenuate muscle mass loss.

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Relationship between sleep patterns and human colonic motor patterns

Cited by 104 publications

References 28 publications

Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility.

Strain Gauge Force Transducer and Its Application in a Pig Model to Evaluate the Effect of Probiotic on Colonic Motility.

Biologic clocks and the gut

Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men

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