Relationship between sleep-disordered breathing and perinatal outcome in pregnant women

BMC Pregnancy Childbirth

et al. 2020

Background: Frequently observed sleep/wake problems among pregnant women need comprehensive evaluation. This study was conducted to clarify the sleep/wake problems among pregnant women without gestational complications during the second and third trimester and the effects of sleep/wake problems on delivery outcomes. Methods: A total of 88 Japanese pregnant women participated in this study. In their second and third trimester, subjective sleep quality, insomnia severity, excessive daytime sleepiness (EDS), and restless legs syndrome/Willis-Ekbom disease (RLS/ WED) were assessed using questionnaires; also, sleep disordered breathing (SDB) was screened using a pulse oximeter. Results: From the second to the third trimester, an increasing tendency of sleep/wake problems was observed. During the third trimester, the percentages of women experiencing decreased subjective sleep quality, difficulty maintaining sleep (DMS), EDS, RLS/WED, and 3% oxygen desaturation index (ODI) values ≥5/h were 62.5, 45.5, 48.9, 9.1, and 29.5%, respectively. In a logistic regression analysis for EDS in the third trimester, the adjusted odds ratio (95% confidence interval) of total sleep duration < 6 h, moderate to severe DMS, and 3% ODI values ≥5/h were 3.25 (1.16-9.10), 4.74 (1.60-14.00), and 0.90 (0.28-2.89), respectively. Although short sleep durations, decreased subjective sleep quality, EDS, and SDB did not affect delivery outcomes or the infant's condition, the percentage of women undergoing cesarean sections in the severe insomnia group was significantly higher (p = 0.008). Conclusions: Sleep/wake problems were frequent during pregnancy, especially during the third trimester. EDS among pregnant women was associated with shorter sleep durations and DMS rather than SDB. The effect of factors related to insomnia on delivery outcomes should thus be considered a crucial problem among pregnant Japanese women without gestational complications in clinical practice.

Section: Sleep Disordered Breathing Among Pregnant Womensupporting

confidence: 94%

“…After removing poor measurement periods, the 3% ODI was calculated, defined as the number of times per hour in which the oxygen saturation decreased by 3% or more from the baseline. Patients who had a 3% ODI ≥ 5/h were defined as having suspected SDB [16].…”

Section: Pulse Oximetermentioning

confidence: 99%

Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications

BMC Pregnancy Childbirth

et al. 2020

“…In the present study, BMI values were higher in pregnant women with a 3% ODI ≥ 5/hour than in those with a 3% ODI < 5/hour from pre-pregnancy to the third trimester; the tendency was clearly noticeable in the later period of pregnancy. These findings are consistent with those of previous studies [10,16,[28][29][30]. However, there were only few participants with obesity in this study.…”

Section: Sleep Disordered Breathing Among Pregnant Womensupporting

confidence: 94%

Section: Pulse Oximetermentioning

confidence: 99%

Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications

et al. 2020

Preprint

Background: Frequently observed sleep/wake problems among pregnant women need comprehensive evaluation. This study was conducted to clarify the sleep/wake problems among pregnant women without gestational complications during the second and third trimester and the effects of sleep/wake problems on delivery outcomes. Methods: A total of 88 Japanese pregnant women participated in this study. In their second and third trimester, subjective sleep quality, insomnia severity, excessive daytime sleepiness (EDS), and restless legs syndrome/Willis-Ekbom disease (RLS/WED) were assessed using questionnaires; also, sleep disordered breathing (SDB) was screened using a pulse oximeter. Results: From the second to the third trimester, an increasing tendency of sleep/wake problems was observed. During the third trimester, the percentages of women experiencing decreased subjective sleep quality, difficulty maintaining sleep (DMS), EDS, RLS/WED, and 3% oxygen desaturation index (ODI) values ≥ 5/hour were 62.5%, 45.5%, 48.9%, 9.1%, and 29.5%, respectively. In a logistic regression analysis for EDS in the third trimester, the adjusted odds ratio (95% confidence interval) of total sleep duration < 6 hours, moderate to severe DMS, and 3% ODI values ≥ 5/hour were 3.25 (1.16–9.10), 4.74 (1.60–14.00), and 0.90 (0.28–2.89), respectively. Although short sleep durations, decreased subjective sleep quality, EDS, and SDB did not affect delivery outcomes or the infant’s condition, the percentage of women undergoing cesarean sections in the severe insomnia group was significantly higher (p = 0.008). Conclusions: Sleep/wake problems were frequent during pregnancy, especially during the third trimester. EDS among pregnant women was associated with shorter sleep durations and DMS rather than SDB. The effect of factors related to insomnia on delivery outcomes should thus be considered a crucial problem among pregnant Japanese women without gestational complications in clinical practice.

Section: Sleep Disordered Breathing Among Pregnant Womensupporting

confidence: 94%

Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications

et al. 2019

Preprint

Background : Frequently observed sleep/wake problems among pregnant women need comprehensive evaluation. This study was conducted to clarify the sleep/wake problems among pregnant women without gestational complications during the second and third trimester and the effects of sleep/wake problems on delivery outcomes. Methods : A total of 88 Japanese pregnant women participated in this study. In their second and third trimester, subjective sleep quality, insomnia severity, excessive daytime sleepiness (EDS), and restless legs syndrome/Willis-Ekbom disease (RLS/WED) were assessed using questionnaires; also, sleep disordered breathing (SDB) was screened using a pulse oximeter. Results : From the second to the third trimester, an increasing tendency of sleep/wake problems was observed. During the third trimester, the percentages of women experiencing decreased subjective sleep quality, difficulty maintaining sleep (DMS), EDS, RLS/WED, and 3% oxygen desaturation index (ODI) values ≥ 5/hour were 62.5%, 45.5%, 48.9%, 9.1%, and 29.5%, respectively. In a logistic regression analysis for EDS in the third trimester, the adjusted odds ratio (95% confidence interval) of total sleep time < 6 hours, moderate to severe DMS, and 3% ODI values ≥ 5/hour were 3.25 (1.16–9.10), 4.74 (1.60–14.00), and 0.90 (0.28–2.89), respectively. Although short sleep times, decreased subjective sleep quality, EDS, and SDB did not affect delivery outcomes or the infant’s condition, the percentage of women undergoing cesarean sections in the severe insomnia group was significantly higher (p = 0.008), and one case of stillbirth with severe sleep/wake problems including RLS/WED, short sleep times, decreased sleep quality, insomnia, and EDS occurred. Conclusions : Sleep/wake problems were frequent during pregnancy, especially during the third trimester. EDS among pregnant women was associated with shorter sleep times and DMS rather than SDB. The effect of factors related to insomnia on delivery outcomes should thus be considered as a crucial problem among pregnant Japanese women without gestational complications in the clinical practice.