Relationship between sex differences in onset of schizophrenia and puberty

Ruiz, Aida; Blanco, Rafael; Santander, Jaime; Miranda, Eduardo

doi:10.1016/s0022-3956(00)00030-3

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…As mentioned earlier, previous studies produced variable results on the relationship between age at puberty and age at first episode of psychosis. Whereas Cohen et al 8 and Galdós et al 9 did report a significant difference working with samples of 32 and 35 women, respectively, other studies' findings, such as those performed by Ruiz et al 11 and Hochman and Lewine, 10 are similar to our results and did not show significant differences, although they worked with larger samples (of 105 and 68 women, respectively).…”

Section: Discussionsupporting

confidence: 83%

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Relationship between menarche and psychosis onset in women with first episode of psychosis

Rubio‐Abadal

Usall

Barajas

et al. 2014

Early Intervention Psych

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Section: Discussionsupporting

confidence: 83%

“…Cohen et al 8 and Galdós et al 9 reported a significant correlation between early puberty and later onset in schizophrenia. On the contrary, the results of similar studies performed by Hochman and Lewine 10 and Ruiz et al 11 did not fully support these findings.…”

Section: Introductionmentioning

confidence: 73%

Relationship between menarche and psychosis onset in women with first episode of psychosis

Rubio‐Abadal

Usall

Barajas

et al. 2014

Early Intervention Psych

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“…[42][43][44][45][46][47][48][49][50] Questionnaire studies 51 have found no relationship between an overall "psychosis proneness" score and puberty timing, but some studies found a correlation between age at menarche and age at onset of symptoms. 42,52,53 Altered pubertal timing was not found in children who received a diagnosis of schizophrenia before age 12. 54 No relationship between timing of puberty and symptom onset was found in boys with schizophrenia.…”

Section: Iq and Psychopathologymentioning

confidence: 94%

Public Health Implications of Altered Puberty Timing

et al. 2008

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Changes in puberty timing have implications for the treatment of individual children, for the risk of later adult disease, and for chemical testing and risk assessment for the population. Children with early puberty are at a risk for accelerated skeletal maturation and short adult height, early sexual debut, potential sexual abuse, and psychosocial difficulties. Altered puberty timing is also of concern for the development of reproductive tract cancers later in life. For example, an early age of menarche is a risk factor for breast cancer. A low age at male puberty is associated with an increased risk for testicular cancer according to several, but not all, epidemiologic studies. Girls and, possibly, boys who exhibit premature adrenarche are at a higher risk for developing features of metabolic syndrome, including obesity, type 2 diabetes, and cardiovascular disease later in adulthood. Altered timing of puberty also has implications for behavioral disorders. For example, an early maturation is associated with a greater incidence of conduct and behavior disorders during adolescence. Finally, altered puberty timing is considered an adverse effect in reproductive toxicity risk assessment for chemicals. Recent US legislation has mandated improved chemical testing approaches for protecting children's health and screening for endocrinedisrupting agents, which has led to changes in the US Environmental Protection Agency's risk assessment and toxicity testing guidelines to include puberty-related assessments and to the validation of pubertal male and female rat assays for endocrine screening.

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“…For example, depression, anxiety, eating, and post-traumatic stress disorders are all more prevalent in women than men, but only after puberty (Kaltiala-Heino et al, 2003;Kessler, 2003;Piccinelli and Wilkinson, 2000;Ruiz et al, 2000). These studies suggest that puberty is a time when women become most vulnerable to stressful experience and some types of psychopathology.…”

Section: Introductionmentioning

confidence: 94%

Distinctive stress effects on learning during puberty

Hodes

Shors

2005

Hormones and Behavior

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Puberty is a time of significant change in preparation for adulthood. Here, we examined how stressful experience affects cognitive and related hormonal responses in male and female rats prior to, during and after puberty. Groups were exposed to an acute stressor of brief periodic tailshocks and tested 24 h later in an associative memory task of trace eyeblink conditioning. Exposure to the stressor did not alter conditioning in males or females prior to puberty but enhanced conditioning in both males and females during puberty. The enhancement occurred in pubescent females irrespective of the estrous cycle. In adulthood, sex differences in trace conditioning and the response to stress emerged: females outperformed males under unstressed conditions, but after stressor exposure, trace conditioning in females was impaired whereas that in males was enhanced. These differences were not related to changes in gross motor activity or other nonspecific measures of performance. The effects of acute stress on corticosterone, estradiol, progesterone, and testosterone were also measured. Stressor exposure increased the concentration of corticosterone in all age groups, although sex differences were only evident in adults. All reproductive hormones except estradiol increased with age in a predictable and sex dependent fashion and none were affected by stressor exposure. Estradiol decreased in male rats across age, and remained stable for female rats. Together, these data indicate that males and female respond similarly to learning opportunities and stressful experience before and during puberty; it is in adulthood that sex differences and the opposite responses to stress arise.

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Relationship between sex differences in onset of schizophrenia and puberty

Cited by 20 publications

References 20 publications

Relationship between menarche and psychosis onset in women with first episode of psychosis

Relationship between menarche and psychosis onset in women with first episode of psychosis

Public Health Implications of Altered Puberty Timing

Distinctive stress effects on learning during puberty

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