Relationship between serum γ‑glutamyltransferase levels and acute exacerbation of chronic obstructive pulmonary disease

Abstract

Relationship between serum γ-glutamyltransferase levels… 85 INTROduCTION Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease associated with abnormal inflammatory response of the lungs to hazardous particles or gases, particularly those found in cigarette smoke. Patients with COPD frequently experience exacerbations that have a negative effect on the quality of life, 1,2 pulmonary function, 3,4 and prognosis. 5 Moreover, episodes of exacerbation generate substantial social and financial costs. Therefore, effective prevention is important both for the patients and healthcare providers. Exacerbations of COPD are associated with the increased levels of various inflammatory markers, including neutrophils and macrophages in the airways as well as cytokines (particularly interleukin [IL] 6 and IL-8). 6 Pathologically, COPD exacerbations appear as "inflammatory flare-ups", regardless of the causative factor (bacterial or viral infections, air pollution, etc). 7 The presence of low-grade systemic inflammation with the elevated circulating levels of tumor necrosis factor-α (TNF-α), IL-6, IL-8, and C-reactive protein (CRP) has been shown to be correlated with restricted airflow in COPD, particularly in exacerbations. 8,9 Oxidative stress is

Kronik Obstrüktif Akciğer Hastalığının Akut Alevlenmesi ile Nötrofil-Lenfosit Oranı ve Serum Ürik Asit Düzeyleri Arasındaki İlişki

“…After adjustment for race, sex, age, cigarette smoking, alcohol intake, and body mass index (BMI), serum concentration of GGT across all deciles was positively associated with serum concentrations of CRP. A strong clinical relationship between CRP and GGT was described [37] In our study we also found positive correlation between GGT levels and CRP as Ermiş et al did [7]. GGT levels are also correlated with smoking status.…”

“…Blood neutrophil to lymphocyte ratio (NLR) is a simple marker of subclinical inflammation that can be easily obtained from the record of a patient's blood cells. Also, serum uric acid (sUA) and gamma-glutamyl transferase (GGT) levels have been associated with increased levels of inflammatory markers that may be important in the outcomes of COPD patients [6,7]. The aim of the study was to evaluate the predictive value of the NLR and possible roles of sUAand GGT as biomarkers in COPD patients.…”

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review

“…By using standardized methods on automatic analyzer, a significant increase of the enzyme activity has been found in COPD compared to healthy controls [110] as well as no difference [111]. A significant increase of GGT activity has also been found in exacerbated COPD compared to stable state [112] whereas no differences have been found in the different stages of the severity of the disease [110]. …”

Serum Gamma-Glutamyl Transferase Activity as a Potential Novel Cardiovascular Biomarker in COPD

“…Gamma-GT, which has an important role in antioxidant defense, is an enzyme responsible for the extracellular catabolism of glutathione, and the level of gamma-GT is a commonly used diagnostic test for liver diseases in clinical practice. 20 In general, an abnormally elevated gamma-GT level is considered as a marker of alcohol abuse and liver damage. However, these factors cannot explain the relationships of gamma-GT with pulmonary function and COPD, because FEV 1 and FVC are clearly decreased, and the prevalence of COPD increased the subjects who had normal alanine aminotransferase levels and irregular alcohol consumption habits.…”