Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

Kara, Ali Veysel; Aldemir, Mehmet Naci; Soylu, Yasin Emrah; Arslan, Yusuf

doi:10.1159/000497242

Cited by 15 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kara In our study, we found that there was no significant correlation between comorbidity index, sex, and KDQOl-36. This finding was inconsistent with previous reports that have indicated a negative correlation between these parameters and HRQOL [35,36]. Since the Kt/V index of our patients was high (Kt/V> 2) and similar in both groups, no correlation was found between the Kt/V index and KDQOL-36.…”

Section: Discussioncontrasting

confidence: 99%

“…Due to the presence of other factors capable of altering the results, we used multiple linear regression analysis to identify whether the independent effect of 25(OH) D. Although in the regression analysis, 25(OH) D level were statistically significant predictors of all KDQOL-36 subscales, it showed a particularly strong interaction with the burden of kidney disease and PCS subscales (p = 0.006 and p = 0.001). These findings were consistent with previous studies which suggested that dialysis patients with Vit-D deficient may have lower physical activity and a weaker mental activity [35,36]. However, it is required further research on this issue…”

Section: Discussionsupporting

confidence: 92%

“…In another study, it was shown that low 25(OH) D levels were associated with lower physical activity and a weaker mental activity [39]. The relationship between 25 (OH) D levels and KDQOL-36 has been previously evaluated in hemodialysis patients [35]. Kara In our study, we found that there was no significant correlation between comorbidity index, sex, and KDQOl-36.…”

Section: Discussionsupporting

confidence: 40%

See 2 more Smart Citations

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

Yüksel

Aydın

2021

Int Urol Nephrol

View full text Add to dashboard Cite

Introduction We aimed to investigate the relationship between Vitamin D level and quality of life in patients undergoing peritoneal dialysis as renal replacement therapy. Methods 50 peritoneal dialysis patients aged between 18 and 73 years were included in this study. KDQOL-36 questionnaire was applied to rate the quality of life of the patients. This questionnaire consisted of 36 questions divided into five subscales. The patients were divided into two groups according to serum vitamin D levels. Patients with a serum 25(OH) D level < 20 ng/mL were identified as vitamin D deficiency group and those with a serum 25(OH)D level ≥ 20 ng/mL were identified as normal vitamin D group. ResultsThe patients had a mean age of 41.16 ± 16.05 years, 56% of them were females. The mean 25(OH) D levels of patients with 25 (OH) D levels < 20 ng/mL and those with ≥ 20 ng/mL were 10.50 ± 4.62 ng/mL and 25.55 ± 4.11 ng/mL, respectively. We found that all subscales of KDQOL-36 were lower with statistically significance in the group with Vitamin D (Vit-D) deficiency. Hemoglobin level was detected as independent risk factor for Symptom and problem list subscales and SF-12 physical component summary subscale (PCS) (P = 0.029, P = 0.047). Vit-D deficiency was detected as independent risk factors for kidney disease burden subscale and PCS (P = 0.035, P = 0.019). Hypertension was detected as independent risk factor for kidney disease burden subscale (P = 0.015). ConclusionOur study is the first to investigate the relationship between serum Vit-D level and quality of life by KDQOL-36 scale in peritoneal dialysis patients. We revealed that patients with low Vit-D levels had worse quality of life in all subscales.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 40%

See 1 more Smart Citation

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

Yüksel

Aydın

2021

Int Urol Nephrol

View full text Add to dashboard Cite

show abstract

“…Few studies have evaluated the QOL scores in HD patients and reported poor QOL in these patients. [12][13][14][15][16] Ibrahim and El Salamony evaluated 60 HD patients in Egypt and reported that their QOL scores were poor (<50 score in all domains). They also found that the high prevalence of depression in these patients was associated with poor QOL.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pomegranate Peel Extract and Vitamin E on Quality of Life in Hemodialysis Patients: A Randomized Placebo-Controlled Clinical Trial

Jafari

Mahmoodnia

Saeidi

2020

Int J Epidemiol Res

View full text Add to dashboard Cite

Background and aims: Quality of life (QOL) is poor in hemodialysis (HD) patients. High oxidative stress and inflammatory conditions disturb their normal physiological, emotional, and physical functions. This study aimed to assess the effects of pomegranate peel extract (PPE) alone and in combination with vitamin E (Vit E) as anti-oxidant and anti-inflammatory substances on QOL of HD patients using Short-form 36 (SF-36) QOL questionnaire. Methods: This study was a double-blinded, placebo-controlled randomized clinical trial on HD patients. A total of 100 HD patients were randomly divided into 4 equal groups as follows: Pom+Vit E group, which received 2 PPE tablets + 1 Vit E soft gel daily, Pom group, which received 2 PPE tablets+1 Vit E placebo soft gel daily, Vit E group, which received 1 Vit E soft gel+2 PPE placebo tablets daily, and Placebo group, which received 2 PPE placebo tablets + 1 Vit E placebo soft gel daily. The intervention duration was 8 weeks. The stratified block randomization method based on sex, age, HD duration, and employment status was used for randomization. Results: The mean age of participants ranged between 51 and 57 years with an HD duration of 9-11.2 months. Bodily pain score and general health score significantly increased in the Pom group and Pom+ Vit E group. The emotional role functioning score of the Pom+Vit E group was significantly higher than that of the placebo group (P<0.05). Conclusion: The consumption of PPE and Vit E had beneficial effects on mental components but not the physical components of QOL. Moreover, combination therapy was more effective than single therapy.

show abstract

“…Beyond its function on calcium-phosphate metabolism, vitamin D exerts several pleiotropic effects [ 10 ]. Vitamin D regulates sleep directly and indirectly, and mounting evidence recommends a connotation between sleep disorders and hypovitaminosis D [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Association of Sleep Quality and Vitamin D Levels in Hemodialysis Patients

Hejazian

Ahmadian

Vahed

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Background. To date, hemodialysis (HD) is the most common therapy for chronic kidney disease (CKD) patients. However, it causes different complications such as sleep disorders. Sleep regulation is connected to vitamin D; hence, its deficiency might influence the quality and duration of sleep. This study is aimed at evaluating the correlation of sleep quality and vitamin D levels in 80 HD patients. Methods. This cross-sectional study was performed on 80 hemodialysis patients admitted to 29 Bahman hospitals in Tabriz, Iran. Before beginning of dialysis, serum 25 (OH) D levels were assessed among patients and the sleep patterns and sleep quality of patients were accurately calculated by the Pittsburgh sleep quality index (PSQI) standard questionnaire. Results. Our results showed that 22 HD patients (27.5%) had severe sleep disorders. In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality ( r = − 0.341 , p = 0.002 ) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level. In poor sleepers ( PSQI ≤ 5 ), a negative correlation was observed between the levels of vitamin D and PSQI score ( r = − 0.397 , p = 0.004 ). PSQI scores in the normal range of PTH ( r = − 0.377 , p = 0.006 ) and in >600 pg/ml of PTH ( r = − 0.675 , p = 0.011 ) had a correlation with vitamin D levels. The level of vitamin D was the single independent predictor of sleep efficiency ( β coefficient = − 0.386 , p = 0.001 ). Conclusion. The present project reported that the positive effect of vitamin D is associated with sleep disorder in HD patients. In future studies, normal levels of Ca and P should be considered along with normal vitamin D levels among the included patients.

show abstract

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

Cited by 15 publications

References 28 publications

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

Effects of Pomegranate Peel Extract and Vitamin E on Quality of Life in Hemodialysis Patients: A Randomized Placebo-Controlled Clinical Trial

The Association of Sleep Quality and Vitamin D Levels in Hemodialysis Patients

Contact Info

Product

Resources

About