Relationship between serum uric acid level and mild cognitive impairment in Chinese community elderly

Liu, Miaomiao; Wang, Jianhua; Zeng, Jing; He, Yao

doi:10.1186/s12883-017-0929-8

Cited by 32 publications

(30 citation statements)

References 26 publications

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“…These data were confirmed in a large cross-sectional study conducted in a Chinese community of 2102 elderly (mean age 71.2 ± 6.6 years old, 59.7% F) between 2009 and 2010. The authors found a linear decrease of MCI prevalence with increasing sUA values, and ORs for MCI was 1.65 (95% CI: 1.12–2.43) and 1.92 (95% CI: 1.02–3.35) for the highest quarters in men and women, respectively [ 25 ]. According to these data, the neuroprotective effects of sUA could start a long time before the onset of clinical manifestations, suggesting a dual benefit in term of risk reduction and clinical improvement of overt disease.…”

Section: Uric Acid and Dementia: Results From Large Epidemiologicamentioning

confidence: 99%

Uric Acid and Cognitive Function in Older Individuals

et al. 2018

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Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing on the etiology of cognitive impairment (Alzheimer’s disease, Parkinson’s dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may exert neuroprotective actions in Alzheimer’s disease and Parkinson’s dementia, with hypouricemia representing a risk factor for a quicker disease progression and a possible marker of malnutrition. Conversely, high serum uric acid may negatively influence the disease course in vascular dementia. Further studies are needed to clarify the physio-pathological role of uric acid in different dementia types, and its clinical-prognostic significance.

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Section: Uric Acid and Dementia: Results From Large Epidemiologicamentioning

confidence: 99%

Uric Acid and Cognitive Function in Older Individuals

et al. 2018

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“…Furthermore, high iron status as indicated by serum ferritin, transferrin, and hemoglobin concentrations has been shown to be positively associated with increased risk of hyperuricemia among participants of the CHNS (42). Moreover, hyperuricemia is related to poor cognitive function in the Chinese population (43). Serum ferritin is also positively associated with build-up of neocortical amyloid-β (44).…”

Section: Discussionmentioning

confidence: 99%

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

Shi

Wang

et al. 2019

The American Journal of Clinical Nutrition

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Background High body iron status has been shown to be associated with adverse health outcomes. However, the relation between high body iron status, body mass index (BMI), and cognition is still understudied. Objective This study aimed to examine the association between iron intake and cognitive function in Chinese adults and tested the interaction effect of iron intake and BMI on cognition. Design Longitudinal study data from a nationwide sample (n = 4852; age ≥55 y) from the China Health and Nutrition Survey during 1991–2006 were used. Of the participants, 3302 had completed cognitive screening tests in ≥2 surveys. Cognitive function was assessed in 1997, 2000, 2004, and 2006. Dietary iron intake was obtained from a 3-d food record during home visits in 1991, 1993, 1997, 2000, 2004, and 2006. Multivariable mixed linear regression and logistic regression were used. Results The cumulative mean ± SD iron intake in 1997 of tested subjects was 23.7 ± 11.3 mg/d (25.4 mg/d in men and 22.2 mg/d in women). High iron intake was associated with poor cognition. In fully adjusted models, across the quartiles of iron intake the regression coefficients (95% CIs) were 0, −0.39 (−0.77, −0.01), −0.55 (−0.95, −0.15), and −0.90 (−1.33, −0.47), respectively. Comparing extreme quartiles of iron intake (high), the OR (95% CI) for poor cognitive function was 1.30 (1.04, 1.64). There was a significant interaction between iron intake and BMI. The association between high iron intake and poor cognition was stronger among those with a high BMI than those with a low BMI. Among those with a BMI (kg/m2) >24, across quartiles of iron intake the ORs (95% CIs) for poor cognitive function were 1.00, 1.27 (0.91, 1.78), 1.41 (0.97, 2.04), and 2.04 (1.38, 3.01), respectively. Conclusion Higher iron intake is associated with poor cognition in Chinese adults, especially among those with a high BMI.

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“…An emerging body of epidemiological studies have indicated that a lower serum UA level is associated with poorer cognitive function and increased risk of mild cognitive impairment (MCI) or overall dementia (Euser et al, 2009;Hong et al, 2015;Liu et al, 2017), although a couple of studies did not find such association (Schretlen et al, 2007;Latourte et al, 2018). Regarding its specific relationship with Alzheimer's disease (AD) dementia, one study reported that serum UA was lower in AD dementia patients than in cognitively normal (CN) healthy controls (Cankurtaran et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment

Kim

Byun

et al. 2020

Front. Aging Neurosci.

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Background: Despite known associations of lower serum uric acid (UA) with Alzheimer's disease (AD) dementia or AD-related cognitive impairment, little is known regarding the underlying patho-mechanisms. We aimed to examine the relationships of serum UA with in vivo AD pathologies including cerebral beta-amyloid (Aβ) and tau deposition, AD-signature region cerebral glucose metabolism (AD-CM), and white matter hyperintensities (WMH). We also investigated the association between serum UA and cognitive performance, and then assessed whether such an association is mediated by the brain pathologies. Methods: A total of 430 non-demented older adults underwent comprehensive clinical assessments, measurement of serum UA level, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging scans. Mini-Mental State Examination (MMSE) and word list recall (WLR) test scores were used to measure cognitive performance. Results: Serum UA level was significantly associated with AD-CM, but not with Aβ deposition, tau deposition, or WMH volume. Serum UA levels also had significant association with WLR and marginal association with MMSE; such associations disappeared when AD-CM was controlled as a covariate, indicating that AD-CM has a mediating effect. Conclusion: The findings of the present study indicate that there is an association of low serum UA with AD-related cerebral hypometabolism, and whether this represents a causal relationship remains to be determined.

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Relationship between serum uric acid level and mild cognitive impairment in Chinese community elderly

Cited by 32 publications

References 26 publications

Uric Acid and Cognitive Function in Older Individuals

Uric Acid and Cognitive Function in Older Individuals

High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults

Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment

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