Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

Yang, Rong; Ma, Xiaojing; Dou, Jianxin; Wang, Feifei; Luo, Yuqi; Li, Diancheng; Zhu, Jiaan; Bao, Yuqian; Jia, Weiping

doi:10.1097/gme.0b013e31828aa32d

Cited by 37 publications

(29 citation statements)

References 29 publications

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“…If anything, there was a suggested inverse association between plasma OC and aortic calcification in older-old women, with a higher degree of aortic calcification at lower plasma OC levels. This corresponds with the results of relatively large studies carried out in community-dwelling populations demonstrating inverse relationships between circulating OC and progression of atherosclerosis (17,38,39,40). The authors attribute this apparent protective effect of OC to a plausible indirect effect via its regulation of glucose and fat metabolism or other unidentified pathways.…”

Section: Discussionmentioning

confidence: 82%

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Holvik

Schoor

Eekhoff

et al. 2014

European Journal of Endocrinology

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Objective: The role of osteocalcin (OC) in cardiovascular disease (CVD) is unresolved. We aimed to study the association between plasma OC concentrations and the risk of non-fatal and fatal CVDs. We also aimed to investigate whether such an association, if present, would be mediated by established metabolic risk factors. Design: A population-based longitudinal cohort study. Methods: In 1995/1996, OC was determined in blood samples drawn from 1319 subjects aged 65-88 years participating in the Longitudinal Aging Study Amsterdam in 1995/1996. The self-reported CVD events were collected every 3 years until 2005/2006, and CVD deaths until 1st January 2007. Cox proportional hazards regression was performed, considering potential confounders (smoking, physical activity, and BMI) and mediators (blood pressure, plasma triglycerides, total and HDL cholesterol, fructosamine, and aortic calcification). Results: During the median 4.1 years follow-up, 709 subjects (53.8%) suffered a CVD event. There was no overall association between OC and CVD: hazard ratio (HR) was 0.97 (95% CI 0.90-1.04) per nmol/l higher plasma OC, adjusted for age and sex. There was a statistical interaction between plasma OC, age, and sex on CVD (PZ0.014). In those subjects aged R75 years, age-adjusted HRs (95% CI) were 0.86 (0.75-0.99) in men and 1.16 (1.03-1.31) in women per nmol/l higher plasma OC. Adjustment for covariates only slightly attenuated the association in older-old men, but did not affect the association in older-old women. Conclusion: A higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. We found no evidence that this was mediated by arterial calcification or metabolic risk factors.

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Section: Discussionmentioning

confidence: 82%

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Holvik

Schoor

Eekhoff

et al. 2014

European Journal of Endocrinology

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“…A description of each study is provided in Table 1. Of the 46 studies included in this review, 26 (56%) were designed specifically to examine the relationship between OC and markers of calcification or atherosclerosis (20, 22, 24–27, 29–47). The other 20 studies evaluated OC among a number of measurements, as a covariate, or in secondary analyses (21, 23, 28, 48–61).…”

Section: Resultsmentioning

confidence: 99%

“…Where studies did not provide mean and SD, authors were contacted for data. In cases where no response from authors was obtained ( n = 8), they could not be included in the statistical analysis (20–27). One author declined to supply requested information (28).…”

Section: Methodsmentioning

confidence: 99%

Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis

et al. 2017

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BackgroundOsteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects. A new line of enquiry between OC and vascular calcification has emerged in response to observations that the mechanism of vascular calcification resembles that of bone mineralisation. To date, studies have reported mixed results. This systematic review and meta-analysis aimed to identify any association between OC and vascular calcification and atherosclerosis.Methods and resultsDatabases were searched for original, peer reviewed human studies. A total of 1,453 articles were retrieved, of which 46 met the eligibility criteria. Overall 26 positive, 17 negative, and 29 neutral relationships were reported for assessments between OC (either concentration in blood, presence of OC-positive cells, or histological staining for OC) and extent of calcification or atherosclerosis. Studies that measured OC-positive cells or histological staining for OC reported positive relationships (11 studies). A higher percentage of Asian studies found a negative relationship (36%) in contrast to European studies (6%). Studies examining carboxylated and undercarboxylated forms of OC in the blood failed to report consistent results. The meta-analysis found no significant difference between OC concentration in the blood between patients with “atherosclerosis” and control (p = 0.13, n = 1,197).ConclusionNo definitive association was determined between OC and vascular calcification or atherosclerosis; however, the presence of OC-positive cells and histological staining had a consistent positive correlation with calcification or atherosclerosis. The review highlighted several themes, which may influence OC within differing populations leading to inconclusive results. Large, longitudinal studies are required to further current understanding of the clinical relevance of OC in vascular calcification and atherosclerosis.

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“…Since then, several clinical studies on the association between osteocalcin and atherosclerosis and CVD have been reported. Some studies demonstrated that serum osteocalcin levels were inversely associated with atherosclerotic parameters and artery calcification [52][53][54][55][56][57][58][59] ; however, other studies reported otherwise 60,61) . Sheng et al 52) showed that serum osteocalcin levels were significantly and inversely associated with IMT and carotid plaques in men with T2DM via a multiple adjustment analysis.…”

Section: Effects Of Osteocalcin On Vascular Cells and Atherosclerosismentioning

confidence: 99%

Association of the roles of advanced glycation end products and osteocalcin between bone metabolism and vascular failure

Kanazawa

2017

Vasc Fail

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Abstract:Fragility fracture impairs the activities of daily living and quality of life of the elderly. Accumulating evidence has shown that patients with osteoporosis have an increased all-cause mortality as well as cardiovascular mortality rates. Osteoporosis and cardiovascular diseases have common risk factors, such as diabetes mellitus. Patients with diabetes have an increased risk of osteoporosis; thus, diabetes-related bone disease is now recognized as one of the complications of diabetes. Although accumulation of advanced glycation end products and oxidative stress are associated with the formation and progression of atherosclerosis, these are reported to be involved in the pathogenesis of osteoporosis, especially in diabetic patients. Moreover, recent studies have shown that osteocalcin, which is secreted from the bone into the circulation, has an endocrine function of regulating glucose and energy metabolism. In addition, osteocalcin directly affects vascular endothelial cells and smooth muscle cells and protects against oxidative stress-induced cell dysfunction. Therefore, the bone-vascular axis attracts widespread attention. In this review, I described the association between bone and glucose metabolism and vascular failure on the basis of recent evidence.

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Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

Abstract: Serum osteocalcin level is negatively associated with subclinical atherosclerosis in Chinese postmenopausal women.

Cited by 37 publications

References 29 publications

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study

Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis

Association of the roles of advanced glycation end products and osteocalcin between bone metabolism and vascular failure

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