Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects

Abstract

OBJECTIVE:To examine the association between serum magnesium levels and C-reactive protein (CRP) in non-diabetic, nonhypertensive obese subjects. DESIGN: Cross-sectional study. SUBJECTS: A total of 371 subjects, 101 men and 270 women. Of them 138 lean (37.2%), 133 (35.9%) overweight, and 100 (26.9%) were obese, matched by age. MEASUREMENTS: Fasting and 2 h serum glucose following a 75 g oral glucose load. Fasting serum total cholesterol, HDL-and LDL-cholesterol, triglycerides, C-reactive protein (CRP), albumin; and magnesium levels; urinary protein excretion; body mass index (BMI), waist-to-hip ratio (WHR), and blood pressure. RESULTS: The presence of CRP was documented in four (2.9%) lean, 13 (9.8%) overweight, and 20 (20.0%) obese subjects, and decreased magnesium levels (equal or less than 1.8 mg=dl), in 2 (1.45%) lean, 7 (5.2%) overweight, and 19 (19%) obese subjects. The lowest serum magnesium levels and the highest CRP concentrations were documented in the obese subjects. Twenty-three (82.1%) of the subjects with low serum magnesium (five overweight and 18 obese) showed CRP concentration equal or more than 10 mg=l. There was a graded significant decrease between CRP concentration and serum magnesium levels (r ¼ 70.39, P ¼ 0.002). The odds ratio (CI 95% ) between magnesium and CRP adjusted by age, sex, BMI and glucose tolerance status for the subjects within the low quartile of magnesium distribution was 2.11 (1.23 -3.84). CONCLUSION:The results of this study show that low serum magnesium levels are independently related to elevated CRP concentration, in non-diabetic, non-hypertensive obese subjects.

Hair Tissue Mineral Analysis and Metabolic Syndrome

“…Severe magnesium deficiency has been shown to increase in inflammatory cytokines as well as to change circulating leukocyte subpopulations [29]. It is apparent that elevated circulating levels of neutrophils and lymphocytes contribute to both the acute and chronic phases of the inflammatory responses in the Mg-deficient rats [30], and CRP was elevated in obese subjects [31]. Furthermore, it has even been proposed that there is a causal link between magnesium deficiency, oxidative stress, and the inflammatory state [32][33][34].…”

The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial

“…On the basis of previous results from healthy subjects of our population, 20 decreased serum magnesium levels were defined by magnesium concentrations p0.74 mmol l À1 . The primary trial end point was a reduction in the systolic (SBP) and diastolic (DBP) BP to the levels lower than 140 and 90 mm Hg, respectively.…”

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

“…La baja concentración de magnesio en suero también se asocia con una alta concentración del marcador inflamatorio PCR (113). El magnesio puede influir en la longitud de los telómeros, al afectar a la integridad del ADN y la reparación, además de su papel en el estrés oxidativo y la inflamación (112)(113)(114)(115)(116)(117)(118)(119).…”