Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

Zeng, Chao; Wei, Jie; Li, Hui; Yang, Tao; Zhang, Fang‐Jie; Pan, Ding; Xiao, Yongbing; Yang, Tubao; Lei, Guanghua

doi:10.3899/jrheum.141414

Cited by 57 publications

(38 citation statements)

References 42 publications

(35 reference statements)

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“…Several studies, including our previous surveys, have revealed that dietary and serum Mg were negatively associated with the prevalence of knee osteoarthritis56575859, indicating that Mg could possess the cartilage or chondrocyte protective effects. In addition to the included experimental studies (Table 3), Mg was reported to be able to regulate the level of sex determining region Y-box 9, which plays a vital role of cartilage growth plates and is required in the successive steps of chondrogenesis60.…”

Section: Discussionmentioning

confidence: 87%

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Zeng

Wei

et al. 2016

Sci Rep

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To examine the analgesic effect and safety of single-dose intra-articular (IA) magnesium (Mg) after arthroscopic surgery. Pubmed, Embase and Cochrane library were searched through in January 2016. Eight RCTs and eight experimental studies were included. The IA Mg exhibited a significantly lower pain score when compared with placebo (MD, −0.41, 95% CI, −0.78 to −0.05, p = 0.03). There was no significant difference between Mg and bupivacaine in terms of pain relief and the time to first analgesic request. Furthermore, statistically significant differences both in pain score (MD, −0.62, 95% CI, −0.81 to −0.42, p < 0.00001) and time to first analgesic request (MD, 6.25, 95% CI, 5.22 to 7.29, p < 0.00001) were observed between Mg plus bupivacaine and bupivacaine alone. There was no statistically significant difference among the various groups with respect to adverse reactions. Most of the included in vitro studies reported the chondrocyte protective effect of Mg supplementation. There were also two in vivo studies showing the cartilage protective effect of IA Mg. The single-dose IA Mg following arthroscopic surgery was effective in pain relief without increasing adverse reactions, and it could also enhance the analgesic effect of bupivacaine. In addition, Mg seemed to possess the cartilage or chondrocyte protective effect based on experimental studies.

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Section: Discussionmentioning

confidence: 87%

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Zeng

Wei

et al. 2016

Sci Rep

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“…There is limited evidence around the consumption of cereals and the relationship to knee OA. However it could hypothesized that a higher intake of cereals could contribute to a lower prevalence of knee OA through anti-inflammatory and anti-oxidative stress action, but also due to these being good sources of vitamins and minerals (such as magnesium [39,40]) which may play a role in lower prevalence of knee OA. However it should be noted that pasta and rice are often consumed in association with olive oil and vegetables and, as supported in previous studies [1,41], not the single components, but the combination of the different ingredients of the Mediterranean diet is responsible for the protective effect and the health benefit observed with this dietary pattern.…”

Section: Discussionmentioning

confidence: 99%

Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: Data from the osteoarthritis initiative

et al. 2017

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Summary Background & aims The Mediterranean diet appears to be beneficial for several medical conditions, but data regarding osteoarthritis (OA) are not available. The aim of this study was to investigate if adherence to the Mediterranean diet is associated with a lower prevalence of OA of the knee in a large cohort from North America. Methods 4358 community-dwelling participants (2527 females; mean age: 61.2 years) from the Osteoarthritis Initiative were included. Adherence to the Mediterranean diet was evaluated through a validated Mediterranean diet score (aMED) categorized into quartiles (Q). Knee OA was diagnosed both clinically and radiologically. The strength of the association between aMED (divided in quartiles) and knee OA was investigated through a logistic regression analysis and reported as odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders. Results Participants with a higher adherence to Mediterranean diet had a significantly lower prevalence of knee OA compared to those with lower adherence (Q4: 25.2% vs. Q1: 33.8%; p < 0.0001). Using a logistic regression analysis, adjusting for 10 potential confounders with those in the lowest quartile of aMED as reference, participants with the highest aMED had a significant reduction in presence of knee OA (OR, 0.83; 95% CIs: 0.69–0.99, p = 0.04). Among the individual components of Mediterranean diet, only higher use of cereals was associated with lower odds of having knee OA (OR: 0.76; 95%CI: 0.60–0.98; p = 0.03). Conclusions Higher adherence to a Mediterranean diet is associated with lower prevalence of knee OA. This remained when adjusting for potential confounders.

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“…The subjects of this cross-sectional study were individuals from the general population who had undergone routine health examinations at Xiangya Hospital, Central South University in Changsha, Hunan, China, between October 2013 and December 2015. Identical study designs have already been reported in some previous publications [24][25][26]. Briefly speaking, the routine health checkups include anthropometric measurements (such as height and body mass), basic clinical tests (such as blood pressure and heart rate), biochemistry (such as blood tests, liver function, kidney function and trace element tests) and imaging tests (such as chest radiography and weight-bearing bilateral anterior-posterior knee radiography).…”

Section: Study Populationmentioning

confidence: 99%

Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study

He¹,

Wang²,

Yang

et al. 2020

BMC Musculoskelet Disord

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Background: Patients with chondrocalcinosis may suffer from a series of symptoms resembling acute gouty arthritis or septic arthritis, but the aetiology and pathogenesis of chondrocalcinosis have not been fully elucidated yet. This study was aimed to assess serum zinc and copper concentrations, as well as the ratio of serum copper to zinc concentrations (Cu/Zn ratio), in relation to the prevalence of knee chondrocalcinosis. Methods: Data included in this analysis were retrieved from a large population-based cross-sectional study. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was diagnosed if definite linear cartilage calcification was detected. Serum zinc and copper concentrations were measured using the spectrophotometric flow injection methods by Roche modular P800. The relations of serum zinc and copper concentrations and Cu/Zn ratio to the prevalence of knee chondrocalcinosis were examined using generalized estimating equations, respectively. Results: The prevalence of knee chondrocalcinosis was 1.2% in the sample of this study (n = 12,362). In comparison with the lowest tertile, the odds ratios (ORs) of knee chondrocalcinosis adjusted by age, sex and body mass index were 0.74 (95% CI 0.50-1.09) in the second and 0.56 (95% CI 0.36-0.86) in the third tertiles of serum zinc concentrations (P for trend = 0.009), were 1.26 (95% CI 0.77-2.05) in the second and 2.01 (95% CI 1.25-3.24) in the third tertile of serum copper concentrations (P for trend = 0.003), and were 1.02 (95% CI 0.61-1.69) in the second and 2.23 (95% CI 1.38-3.59) in the third tertile of Cu/Zn ratio (P for trend < 0.001) respectively. These findings were not materially altered by adjustment for potential confounders. Conclusions: The present study observed that higher serum zinc concentrations, lower serum copper concentrations or lower Cu/Zn ratio are associated with a lower prevalence of knee chondrocalcinosis in a doseresponse relationship manner.

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Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

Abstract: Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.

Cited by 57 publications

References 42 publications

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: Data from the osteoarthritis initiative

Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study

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