Relationship between serum levels of IL-10, MRI activity and interferon beta-1a therapy in patients with relapsing remitting MS

Waubant, Emmanuelle; Gee, Lauren; Bacchetti, Peter; Sloan, R.; Cotleur, Anne C.; Rudick, Richard A.; Goodkin, D E

doi:10.1016/s0165-5728(00)00355-6

Cited by 55 publications

(45 citation statements)

References 27 publications

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“…These findings are consistent with reports that overexpression of IL-10 protects against EAE disease, whereas deletion of IL-10 exacerbated disease (Bettelli et al, 1998;Cua et al, 2001). In MS patients, it has been reported that serum concentrations of IL-10 are increased during disease remission (Waubant et al, 2001). Furthermore, the efficacies of IFN-b and glatiramer acetate as therapies in MS are partly attributed to their induction of IL-10 production (Ersoy et al, 2005;Putheti et al, 2003).…”

Section: Discussionsupporting

confidence: 91%

“…Studies in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), have shown that infection with the helminth parasite Fasciola hepatica attenuated symptoms of EAE through TGF-b-mediated suppression of Th1 and Th17 responses (Walsh et al, 2009). The bacteria Staphyloccus aureus is also capable of suppressing EAE through an extracellular adherence protein, which has anti-inflammatory effects by binding to ICAM-1 and preventing the infiltration of myelin specific T cells across the blood brain barrier into the CNS (Waubant et al, 2001 Bordetella pertussis causes whooping cough which, despite high vaccine coverage, is a re-emerging infectious disease that affects a high proportion of adults as well as children (Cherry, 2014). Infection with B. pertussis is persistent even in an immunocompetent host, with the bacteria taking weeks or months to be cleared through a combination of innate and adaptive immune responses, the latter involving IFN-c-secreting Th1 cells and IL-17-producing Th17 cells (Higgs et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

Edwards

Higgins

Mills

2015

Brain, Behavior, and Immunity

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

Edwards

Higgins

Mills

2015

Brain, Behavior, and Immunity

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“…Furthermore, PBMCs from normal pregnant women secrete higher amounts of IL-10 when stimulated with PHA as compared with nonpregnant controls (4). IL-10 is thought to ameliorate disease activity in MS (5).…”

Section: Ultiple Sclerosis (Ms)mentioning

confidence: 99%

Late Pregnancy Suppresses Relapses in Experimental Autoimmune Encephalomyelitis: Evidence for a Suppressive Pregancy-Related Serum Factor

Langer‐Gould

Garren

Slansky

et al. 2002

The Journal of Immunology

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Women with multiple sclerosis have significantly diminished disease activity during pregnancy. The purpose of our study was to identify the underlying mechanism for the diminished disease activity. We found that during the period of late pregnancy there is protection against paralysis, during both the induction and effector phases of relapsing experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. We did not find any changes in the cytokine secretion profiles or the proliferative activity of autoreactive T cells from mice induced during late pregnancy compared with virgin controls. In mice mated after disease onset, the inflammatory histologic lesions did not clear, despite marked clinical improvement during pregnancy. We found evidence for a serum factor present in late pregnancy that suppresses T cell activation. In the presence of sera taken from mice late in pregnancy, the proliferative response and IL-2 production of proteolipid protein p139–151-specific T cells were significantly diminished as compared with stimulation in the presence of normal mouse sera. In conclusion, serum from late pregnancy has the capacity to down-regulate T cell responses and might be associated with the amelioration of disease activity in experimental autoimmune encephalomyelitis.

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“…IL-10 acts to decrease inflammatory cytokine production by macrophages (Imitola et al, 2005). IL-10 secretion by PBMC from MS patients is decreased prior to relapse and increased during remission (Rieckmann et al, 1994,Pelfrey et al, 2000,Waubant et al, 2001. Endogenous IL-10 levels may also influence severity of disease (Luomala et al, 2003,Van Boxel-Dezaire et al, 1999.…”

Section: Introductionmentioning

confidence: 99%

Cytokine changes during interferon-beta therapy in multiple sclerosis: Correlations with interferon dose and MRI response

Graber

Ford

Zhan

et al. 2007

Journal of Neuroimmunology

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We investigated serum (IL-10 and IL-12p70) and cellular cytokine levels (IL-10, IL-12p40, IL-12p70, IFN-γ) in stimulated PBMC over 24 weeks in 15 Relapsing Remitting Multiple Sclerosis (MS) patients randomized to receive once-weekly (qw) IFN-β-1a 30 ug intramuscularly (IM) (n=8) or three-times-weekly (tiw) IFN-β-1a 44 ug subcutaneously (SC) (n=7). Overall, IFN-β treatment increased cellular IL-10 (p<0.01) levels and the ratios of cellular IL-10/IL-12p40 (p<0.01) and IL-10/ IL-12p70 (p<0.02) while cellular IFN-γ levels were reduced (P<0.01). Serum IL-10 levels were decreased in non-responders to therapy based on MRI-defined criteria (p<0.01) but did not change in responders over the course of treatment. In addition, non-responders demonstrated a decrease in serum IL-10/IL-12p70 ratio (p=0.031) and a decrease in cellular IL-12p70 (p<0.02). A decrease in cellular IFN-γ was observed in responders (p=0.013). This is the first study that compares cytokine changes between the two IFN-β regimes and demonstrates that serum IL-10 levels decrease in those patients who continue to have active MRI lesions while on interferon-beta therapy.

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Relationship between serum levels of IL-10, MRI activity and interferon beta-1a therapy in patients with relapsing remitting MS

Cited by 55 publications

References 27 publications

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

Late Pregnancy Suppresses Relapses in Experimental Autoimmune Encephalomyelitis: Evidence for a Suppressive Pregancy-Related Serum Factor

Cytokine changes during interferon-beta therapy in multiple sclerosis: Correlations with interferon dose and MRI response

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