Relationship between serum estradiol, cathepsin K, and N-telopeptide of type I collagen in female dogs

Yamaguchi, Fumi; Nishi, Hiroshi; Kuramoto, Tomohide; Saitoh, Yasuo; Sogawa, Takeshi; Misumi, Kazuhiro; Fujiki, Makoto

doi:10.1016/j.rvsc.2020.03.015

Cited by 2 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that cortical and cancellous bone cell volume in adult and aged dogs gradually decreases with advancing age, similar to that in humans 4,5 . However, the lack of substantial responses in histomorphometric, bone mass, and biochemical measurements may restrict the use of dogs in studies of cancellous bone loss during ovarian dysfunction osteoporosis 6 . The hierarchical organization of canine and human compact bone is comparable; however, the exact causes for this species difference are unknown.…”

Section: Introductionmentioning

confidence: 99%

“…bone mass, and biochemical measurements may restrict the use of dogs in studies of cancellous bone loss during ovarian dysfunction osteoporosis. 6 The hierarchical organization of canine and human compact bone is comparable; however, the exact causes for this species difference are unknown. A study of sex variation in bone metabolism indicators of dogs found substantial differences in both sexes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The influence of sex and age on bone turnover markers in the adult to geriatric Kangal shepherd dogs

Ekici

Koçkaya

EKİCİ

2023

Veterinary Clinical Pathol

View full text Add to dashboard Cite

Objectives The objective of this research was to learn more about bone metabolism in intact female and male Kangal shepherd dogs during the aging process following skeletal maturity. It also evaluated the potential application of biochemical bone indicators in veterinary clinical practice. Methods Bone markers were determined as bone alkaline phosphatase (BALP), osteocalcin (OC), C‐terminal telopeptide of type I collagen (CTX), and cross‐linked C‐telopeptide of type I collagen (ICTP) in this study. Kangal shepherd dogs of different age (adult, senior, and geriatric) and sex (male and female) groups were split into six groups of equal numbers (n = 8/group). Results In this study, the effect of age was observed on serum BALP, OC, CTX, and ICTP concentrations. Specifically, BALP was highest in geriatric female Kangal shepherd dogs, while serum OC, CTX, and ICTP concentrations were highest in geriatric male Kangal shepherd dogs. However, no effects of sex and age–sex interactions were identified. Moreover, the effects of age, sex, and age–sex interactions had no significant effect on serum creatinine, CK, LDH, Mg, and P concentrations or ALT activities. However, only sex was found to affect serum AST activities and gradually decreased with age in females. The effect of age and age–sex interactions on serum Ca concentrations was significant (the lowest serum Ca concentrations were in geriatric females), but the effect of sex was not. Conclusions These results show the effect of age and sex on bone turnover in Kangal shepherd dogs and provide information about bone biomarkers.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%