Relationship Between Serum Cystatin C and Creatinine or Dialysis Adequacy in Patients on Chronic Maintenance Hemodialysis

Khorgami, Zhinoos; Abdollahi, Alireza; Soleimani, Samaneh; Ahamadi, F; Mahdavi‐Mazdeh, Mitra

doi:10.5812/numonthly.4934

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…We studied a larger number of patients and compared GFR in normal and different stages of CKD. Our study also confirmed the previous studies with more solid data in wider range of kidney function [14]. However, Hejes, et al insisted that cystatin C-based GFR formula was more accurate than creatininebased GFR formula in patients with GFR<60cc/min/m 2 [11].…”

Section: Discussionsupporting

confidence: 90%

Cystatin C versus creatinine-based GFR formula in CKD patients

Abrishami¹,

Mahdavi‐Mazdeh²,

Minoo³

et al. 2015

BANTAO Journal

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Introduction. Glomerular Filtration Rate (GFR) is the main tool to assess kidney function. Some experts suggest cystatin C as a more precise and accurate indicator than creatinine to calculate GFR. This study is designed to assess if cystatin C is more helpful in early diagnosis and better follow-up of Chronic Kidney Disease (CKD) patients who may benefit more from appropriate and timely management. Methods. We studied 312 patients in different stages of CKD and normal kidney function as control. GFR based on creatinine (Jaffe and enzymatic) and cystatin C were calculated and compared. Results. A total of 146(46.8%) patients were male with a mean age of 53±17.5 years. The patients were divided into 3 groups based on GFR (>60 cc/min/1.73m 2, 30< GFR<60cc/min/1.73m 2, 15<GFR<30cc/min/1.73m 2). No significant differences in GFR estimation based on creatinine and cystatin C were found. Conclusions. There were no significant differences between serum cystatin C-based formula and creatinine-based formula for GFR calculation. Therefore, they can be used interchangeably.

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Section: Discussionsupporting

confidence: 90%

Cystatin C versus creatinine-based GFR formula in CKD patients

Abrishami¹,

Mahdavi‐Mazdeh²,

Minoo³

et al. 2015

BANTAO Journal

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“…The mean correlation coefficient for the inverse of serum cystatin C (1/serum cystatin C) from 36 data sets (R = 0.816, 95% CI = 0.804-0.826) ( 28 ) was much higher than that from the current study (R = 0.25). Similarly, Khorgami et al demonstrated the statistically significant correlation (P < 0.001) between serum cystatin C and simplified MDRD as well as cystatin C-based formula in chronic hemodialysis individuals with correlation coefficients of -0.46 and -0.87, respectively ( 29 ). This difference can be partially explained by the characteristics of patients.…”

Section: Discussionmentioning

confidence: 94%

Serum Cystatin C as a Marker of Renal Function in Critically Ill Patients With Normal Serum Creatinine

et al. 2014

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Background:Serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction.Objectives:This study assessed the validity of serum cystatin C as a marker of renal function in critically ill patients with normal serum creatinine.Patients and Methods:Eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg/dL and without hemodynamic instability were chosen and their serum creatinine and cystatin C levels were measured. A 24-hour urine sample was collected to calculate creatinine clearance (Ccr). Renal dysfunction was defined as Ccr < 80 mL/min/1.73 m2.Results:There were significant correlations between measured Ccr and 1/serum creatinine (R = 0.51, P < 0.001) and 1/serum cystatin C (R = 0.25, P = 0.028). The difference between false negative rates of serum creatinine (93.33%) and cystatin C (80%) in the detection of renal dysfunction was significant (P = 0.032). Receiver operating characteristic curve analysis illustrated that area under the curve of serum creatinine and cystatin C for detecting renal dysfunction were 0.711 and 0.607, respectively; however, this difference was not significant (P = 0.222).Conclusions:Our data demonstrated that serum cystatin C is not superior to serum creatinine in the early detection of renal dysfunction in critically ill patients.

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“…Serum cystatin C has been proposed in this regard. [8][9][10][11][12][13] Cystatin C is a non-glycosylated protein of the cysteine proteinase inhibitors family that is produced by nearly all nucleated cells in the human body. 14,15 The production rate of this low molecular weight protein of 13 kDa is nearly constant, and is independent of age, sex, and body mass index(BMI).…”

Section: Introductionmentioning

confidence: 99%