Relationship between serum calcium and neuropsychological performance might indicate etiological heterogeneity underlying cognitive deficits in schizophrenia and depression

Sharma, Anuradha; Schray, Angela; Bartolovic, Marina; Roesch-Ely, Daniela; Aschenbrenner, Steffen; Weisbrod, Matthias

doi:10.1016/j.psychres.2017.01.101

Cited by 18 publications

(11 citation statements)

References 45 publications

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“…The Cognitive Basic Assessment test set (COGBAT) from the Vienna test system [16] efficiently assesses the key neuropsychological dimensions of attention, memory, executive functions, and processing speed and has been validated across neurological and psychiatric populations [17, 18]. The tests are presented in a fixed order and take 60 min to complete.…”

Section: Methodsmentioning

confidence: 99%

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

et al. 2019

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Purpose: Cognitive impairment and reduced quality of life is a common condition in patients with heart failure (HF). Percutaneous mitral valve repair using (PMVR) MitraClip (MC) has emerged as a promising interventional tool, reducing all-cause mortality and hospitalization as well as increasing cognitive functioning and quality of life. However, the benefit of HF patients with severely depressed cognitive functioning remains unknown. Methods:We assessed cognitive functioning (figural memory-FGT, executive function-TOL, TMT B), psychosocial functioning (depression-PHQ-9, quality of life-SF36), and clinical parameters (echocardiography, 6-min walk test distance, and cardiac biomarkers) 1 day before (t0) and 6 weeks after (t1) MC intervention in HF patients (n = 40). First, paired sample t tests were conducted to uncover improvements in cognitive functioning post-MC intervention. Second, the COGBAT Norm-sample, a representative age-matched healthy sample, was used to compare participants' individual scores. Third, bivariate linear regressions were calculated for all key predictors of the detected improvements in cognitive functioning post-MC intervention (t1-t0). Results:Following the MC intervention, we found significant improvements in figural memory, executive functioning, and psychosocial functioning. Most of the patients with depressed executive functioning before the MC intervention showed post-intervention test scores within the normal range (> 50th percentile; t0 22.5% vs. t1 60%) as compared to the normative COGBAT sample. Regression analyses revealed that lower baseline scores in planning ability before the MC intervention (t0) were associated with greater planning ability (TOL; B = − 0.78, 95% CI − 1.04 to − 0.53), figural memory (FGT; B = − 0.26, 95% CI − 0.44 to − 0.07), and cognitive flexibility (TMT B; B = − 0.36, 95% CI − 0.50 to − 0.23) improvement post-MC intervention (t1-t0). Psychosocial functioning and age were not associated with these improvements. Conclusions:Patients with depressed executive functioning showed the greatest benefit from the MC intervention regarding cognitive functioning. Age and psychological functioning seem less important for cognitive performance improvements post-MC intervention. Hence, severely depressed cognitive functioning in patients is not a contraindication for PMVR using MitraClip.

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Section: Methodsmentioning

confidence: 99%

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

et al. 2019

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“…Tight regulation of calcium signaling is critical for many important functions of the brain, and subtle impairment in calcium signaling or disturbed calcium homeostasis can result in deleterious consequences including neuronal death [ 32 ] and age-related cognitive decline [ 33 - 35 ]. DM increases the risk of developing renal failure and contributes to impediment to phosphorus excretion from kidney, and thus leads to hyperphosphatemia.…”

Section: Potential Mechanism In the Development Of Diabetic Cognitmentioning

confidence: 99%

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Xing¹,

Tang²,

Lei³

et al. 2020

Aging and disease

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The goal of this review was to summarize current biochemical mechanisms of and risk factors for diabetic brain injury. We mainly summarized mechanisms published in the past three years and focused on diabetes induced cognitive impairment, diabetes-linked Alzheimer's disease, and diabetic stroke. We think there is a need to conduct further studies with increased sample sizes and prolonged period of follow-ups to clarify the effect of DM on brain dysfunction. Additionally, we also think that enhancing experimental reproducibility using animal models in conjunction with application of advanced devices should be considered when new experiments are designed. It is expected that further investigation of the underlying mechanisms of diabetic cognitive impairment will provide novel insights into therapeutic approaches for ameliorating diabetes-associated injury in the brain.

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“…We had access to GAF-F, which has been reg- (Samara et al, 2014;Suzuki et al, 2015). GAF-F has been used in clinical practice and research for decades, and is still used in clinical practice in Denmark and other Nordic and European countries (Aas et al, 2016;Awan et al, 2017;Baandrup et al, 2012;Baandrup et al, 2016;Schurhoff et al, 2015;Sharma et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Despite of the fact that the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐V) Task Force decided that GAF was not an adequate instrument and introduced a new tool to assess global functioning and impairment (American Psychiatric Association, ), GAF‐F captures psychological, social and occupational functioning and correlates well with other measures of functioning (Samara et al, ; Suzuki et al, ). GAF‐F has been used in clinical practice and research for decades, and is still used in clinical practice in Denmark and other Nordic and European countries (Aas et al, 2016; Awan et al, 2017; Baandrup et al, ; Baandrup et al, ; Schurhoff et al, ; Sharma et al, ).…”

Section: Discussionmentioning

confidence: 99%

Association between global functioning at first schizophrenia diagnosis and treatment resistance

Horsdal

Wimberley

Köhler‐Forsberg

et al. 2017

Early Intervention Psych

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Relationship between serum calcium and neuropsychological performance might indicate etiological heterogeneity underlying cognitive deficits in schizophrenia and depression

Cited by 18 publications

References 45 publications

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Association between global functioning at first schizophrenia diagnosis and treatment resistance

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