Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis

Miyashita, Hirotaka; Honda, Takeshi; Maekawa, Tomoki; Takahashi, Naoki; Aoki, Y.; Nakajima, Takako Eguchi; Tabeta, Koichi; Yamazaki, Kazuhisa

doi:10.1016/j.archoralbio.2011.11.008

Cited by 18 publications

(24 citation statements)

References 40 publications

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“…Particularly, the inflammatory response accompanying periodontitis has been proposed as an important factor that may exert adverse effects on the regulation of BP (Table 2). The level of serum high-sensitivity CRP (hs-CRP), an acute-phase reactant that has been reported to predict the outcome of CVD, was found to be more increasing in patients with periodontitis than in control subjects, and it decreased significantly after periodontal treatment [73–75]. …”

Section: Possible Linking Pathways For the Association Between Hypmentioning

confidence: 99%

Association between Hypertension and Periodontitis: Possible Mechanisms

Leong

Baharin

et al. 2014

The Scientific World Journal

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This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. Inflammation has received much attention recently and may contribute to a pivotal role in hypertension. Periodontitis, a chronic low-grade inflammation of gingival tissue, has been linked to endothelial dysfunction, with blood pressure elevation and increased mortality risk in hypertensive patients. Inflammatory biomarkers are increased in hypertensive patients with periodontitis. Over the years, various researches have been performed to evaluate the involvement of periodontitis in the initiation and progression of hypertension. Many cross-sectional studies documented an association between hypertension and periodontitis. However, more well-designed prospective population trials need to be carried out to ascertain the role of periodontitis in hypertension.

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Section: Possible Linking Pathways For the Association Between Hypmentioning

confidence: 99%

Association between Hypertension and Periodontitis: Possible Mechanisms

Leong

Baharin

et al. 2014

The Scientific World Journal

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“…The levels of serum biomarkers (interleukin‐6, TNF‐α, sCD14, hs‐CRP, PCSK9, MPO, MMP‐3, ADPN, and TBIL) shared between periodontitis and atherosclerotic disease were compared between periodontally healthy subjects and those with periodontal disease (Figure ). The concentrations of PCSK9 and hs‐CRP were significantly higher in subjects with periodontal disease than in periodontally healthy subjects ( P = .001 and .042, respectively), whereas TBIL was significantly lower in subjects with periodontal disease ( P = .046).…”

Section: Resultsmentioning

confidence: 99%

“…The clinical manifestation of periodontitis is influenced by multiple factors, such as oral hygiene status and anatomic features, including tooth morphology and alignment, as well as the form and location of tooth furcation . Accordingly, it is reasonable that the correlation of serum biomarkers to clinical periodontal status was not very strong, even when serum biomarkers were used as surrogate markers reflecting average periodontal status . In fact, the correlation of serum PCSK9 to clinical periodontal status was weak, but statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past few decades, several serum biomarkers and molecules that reflect the host response to periodontitis have been reported, such as high‐sensitivity C‐reactive protein (hs‐CRP), tumor necrosis factor (TNF)‐α, interleukin‐6, soluble (s) CD14, and specific antibodies to periodontal bacteria . These markers are used to monitor inflammation and are also possible mediators linking periodontal inflammation to systemic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey

Tabeta

Hosojima

Nakajima

et al. 2018

J of Periodontal Research

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In Japanese male subjects, the concentrations of serum PCSK9 and TBIL were correlated with periodontal parameters. Moreover, PCSK9 could be a candidate biomarker for diagnosing chronic periodontitis, and may also have potential to evaluate the risk for periodontitis to cause ASVD. Longitudinal studies of larger populations are necessary to confirm the exact association of periodontitis with increased serum PCSK9 and decreased TBIL.

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“…, Miyashita et al. ). With regard to the involvement of antibody to P. gingivalis in periodontitis progression, serum titres of antibody to P. gingivalis have been considered elevated in response to subgingival P. gingivalis colonization (Kojima et al.…”

Section: Discussionmentioning

confidence: 98%