Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes

Obata, Yoshinari; Yamada, Yuya; Takahi, Yasumitsu; Baden, Megu Y; Saisho, Kenji; Tamba, Sachiko; Yamamoto, Kōji; Umeda, Miyuki; Furubayashi, Aiko; Matsuzawa, Yūji

doi:10.1111/cen.12041

Cited by 76 publications

(63 citation statements)

References 38 publications

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“…Our study also showed significant negative correlation with age and serum adiponectin levels. This finding was contradicted by Obata Y. et al, 10 2013 as they observed that serum adiponectin levels are significantly and positively associated with age in healthy subjects, but finding of our study was supported by Sunita J Ramanand et al, 11 2014 as they found that adiponectin levels decreases as age advances.…”

Section: Discussioncontrasting

confidence: 89%

Correlation of gender and age with serum adipokines level in north indian adults

et al. 2015

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Objective: There are two forms of adipose tissue, brown adipose tissue (BAT) and white adipose tissue (WAT). Distribution of adipose tissue differs in different gender and different age group. Adipose tissue expresses various secretary proteins, including leptin and adiponectin, collectively called adipokines. The purpose of this study to elucidated the correlation of serum leptin, serum adiponectin levels with age and gender in north Indian population. Materials and Methods: 100 subjects (55 male, 45 female) aged between 18-25 yrs were included in the study. Blood sample were taken after overnight fasting for biochemical assay. Serums were separated by centrifugation method. Serum leptin and serum adiponectin were analyzed by using RayBio ELISA Kit. Result: The serum leptin (pg) was significantly (p=0.001) higher among female (428.28±83.06) subjects compared with males (365.42±102.56). Similarly, serum adiponectin (pg) level was also significantly (p=0.02) higher among females (5313.15±1151.12) than males (4794.72±1078.38). The age was mildly and negatively correlated with Serum adiponectin (r= -0.317, p=0.001) and had no correlation with serum leptin levels. Conclusion: Serum adipokines levels in young north Indian adults are influenced by gender and age of subjects, suggests that female subject, relative to the males, are at increased risk for obesity-related metabolic co-morbidities.

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Section: Discussioncontrasting

confidence: 89%

Correlation of gender and age with serum adipokines level in north indian adults

et al. 2015

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“…In healthy human individuals, plasma adiponectin levels increase with increasing age and an elevation of w1 mg/l of circulating adiponectin has been reported for every 10 years of age (Obata et al 2013). Moreover, plasma adiponectin levels are higher in women than in men (Obata et al 2013). Taking into account the wide range of variability of circulating adiponectin in healthy humans, strict cutoffs cannot be defined.…”

Section: Plasma Adiponectin Levelsmentioning

confidence: 99%

“…Taking into account the wide range of variability of circulating adiponectin in healthy humans, strict cutoffs cannot be defined. However, a crude estimation of plasma adiponectin levels in non-elderly healthy individuals is between 4 and 10 mg/l for males and between 6 and 15 mg/l for females (Isobe et al 2005, Obata et al 2013.…”

Section: Plasma Adiponectin Levelsmentioning

confidence: 99%

The role of adiponectin in renal physiology and development of albuminuria

Christou¹,

Kiortsis²

2014

Journal of Endocrinology

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Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and insulin resistance. There is a growing body of evidence indicating that adiponectin has renoprotective effects and protects against the development of albuminuria in rodent experiments. Adiponectin crossing the glomerular filtration barrier possibly inhibits inflammation, fibrosis and oxidative stress in kidneys through activation of AMP-activated protein kinase. Moreover, microalbuminuria is a well established early sign of progressive cardiovascular and renal disease, even in subjects with preserved glomerular filtration rate. Studies investigating the relationship between serum adiponectin levels and urinary albumin excretion rate (UAE) have yielded conflicting data and the mechanisms underlying the interplay between adiponectin and albuminuria remain to be elucidated. This article constitutes a critical review attempting to clarify any remaining confusion about this matter. Furthermore, this article examines the clinical significance of adiponectin-albuminuria interplay, suggesting that adiponectin is possibly involved in the development of albuminuria that is associated with obesity, diabetes and cardiovascular disease and may mediate, at least in part, the actions of medical treatments that influence UAE, such as angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, thiazolidinediones, fenofibrate and diet. Further studies to investigate more thoroughly the renoprotective role of adiponectin in the human setting should be carefully planned, focusing on causality and the possible influence of adiponectin on the development of albuminuria in specific clinical settings.

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“…In the normal ovary, the granulosa cells express EGFR from the primordial follicle stage onward (Prigent et al 1992, Qu et al 2000, and during ovulation, LH surge stimulates mural granulosa cells to secrete EGF-like ligands, which subsequently bind to EGFR on cumulus cells surrounding the oocyte. This enables cumulus expansion, oocyte maturation, and ovulation (Park et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of human granulosa cell tumor cells to epidermal growth factor receptor inhibition

Andersson¹,

Anttonen²,

Färkkilä³

et al. 2014

Journal of Molecular Endocrinology

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Epidermal growth factor receptor (EGFR) is implicated in the progression of many human cancers, but its significance in ovarian granulosa cell tumor (GCT) pathobiology remains poorly understood. We assessed the EGFR gene copy number, surveyed the mRNA and protein expression patterns of EGFR in 90 adult GCTs, and assessed the in vitro sensitivity of GCTcells to EGFR inhibition. Low-level amplification of EGFR gene was observed in five GCTs and highlevel amplification in one sample. EGFR mRNA was robustly expressed in GCTs. Most tumors expressed both unphosphorylated and phosphorylated EGFR protein, but the protein expression did not correlate with clinical parameters, including the risk of recurrence. Smallmolecule EGFR inhibitors reduced the EGF-induced activation of EGFR and its downstream signaling molecules at nanomolar doses, but cell viability was reduced, and caspase-3/7 was activated in GCTcells only at micromolar doses. Based on the present results, EGFR is active and abundantly expressed in the majority of GCTs, but probably has only minor contribution to GCT cell growth. Given the high doses of EGFR inhibitors required to reduce GCT cell viability in vitro, they are not likely to be effective for GCT treatment as single agents; they should rather be tested as part of combination therapies for these malignancies.

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Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes

Abstract: Serum adiponectin levels are significantly and positively associated with age in healthy subjects and in patients with diabetes. This association is independent of renal function, body fat status, glucose metabolism and lipid profiles.

Cited by 76 publications

References 38 publications

Correlation of gender and age with serum adipokines level in north indian adults

Correlation of gender and age with serum adipokines level in north indian adults

The role of adiponectin in renal physiology and development of albuminuria

Sensitivity of human granulosa cell tumor cells to epidermal growth factor receptor inhibition

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