Relationship between Serum 25-hydroxyvitamin D Concentration and the Risks of Metabolic Syndrome in Premenopausal and Postmenopausal Women

Kim, You Jin; Moon, Min Sun; Yang, Yoon Jung; Kwon, Oran

doi:10.4163/kjn.2012.45.1.20

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…In Korea, there have been no reports concerning a definite cut-off value of serum vitamin D concentration, although some studies described a mean serum vitamin D level. According to the 4th Korea National Health and Nutrition Examination Survey (2007-2009), the mean serum 25OHD level of 1,613 premenopausal women was 17.2 ± 6.3 ng/mL,25) and that of 2,878 women who had a medical check-up at a university hospital during the autumn was 19.1 ng/mL 26)…”

Section: Discussionmentioning

confidence: 99%

Effect of Sunlight Exposure on Serum 25-Hydroxyvitamin D Concentration in Women with Vitamin D Deficiency: Using Ambulatory Lux Meter and Sunlight Exposure Questionnaire

et al. 2012

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BackgroundVitamin D is an important factor in human health. Yet, vitamin D deficiency is very common. We aimed to confirm serum 25-hydroxyvitamin D (25OHD) concentration change after sunlight exposure and to elucidate the relationship between the amount of sunlight exposure and serum 25OHD level change by ambulatory lux meter and sunlight exposure questionnaire.MethodsTwenty healthy young women were enrolled. They were educated to obtain 20 minutes of sunlight exposure during weekdays from October to November, 2010, during which they were to wear an ambulatory lux meter on an arm. All subjects completed a one-week recall sunlight exposure questionnaire at the end of the study. Before and after sunlight exposure, serum 25OHD level was measured.ResultsMean pre-exposure serum 25OHD concentration was 11.01 ng/mL. The mean change of pre- and post-exposure 25OHD level was -0.62 ng/mL, but it was not statistically significant. The mean personal sunlight exposure recorded by ambulatory lux meter, 292.6 lux/s, showed no significant relationship with average change of 25OHD and average weekly sunlight exposure score, 11.9, calculated by the sunlight exposure questionnaire. However, the mean change of serum 25OHD level and weekly sunlight exposure score showed significant negative correlation (r = -0.469, P = 0.037).ConclusionChange of serum 25OHD concentration after four weeks of sunlight exposure was not statistically significant in women with vitamin D deficiency. However, serum 25OHD concentration change was significantly negatively correlated with the sunlight exposure score by the questionnaire.

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Section: Discussionmentioning

confidence: 99%

Effect of Sunlight Exposure on Serum 25-Hydroxyvitamin D Concentration in Women with Vitamin D Deficiency: Using Ambulatory Lux Meter and Sunlight Exposure Questionnaire

et al. 2012

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Serum 25-hydroxyvitamin D levels and dyslipidemia: a systematic review and dose-response meta-analysis of epidemiologic studies

2022

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Context Findings of previous observational studies that examined the association between circulating vitamin D levels and lipid profiles have been inconsistent. Objective A dose-response meta-analysis of epidemiologic studies was conducted to investigate the relationship between serum 25-hydroxyvitamin D levels and dyslipidemia in adults. Data Sources Electronic databases were searched systematically for articles published up to June 2021. Data Extraction Fifty-seven observational studies and 2 cohort studies that reported odds ratios (ORs) or relative risks (RRs) with 95%CIs for dyslipidemia in relation to serum 25-hydroxyvitamin D levels in adults were included. Data Analysis A high level, vs a low level, of serum 25-hydroxyvitamin D was related to a significant 19% decrease in the odds of hypertriglyceridemia (OR 0.81; 95%CI, 0.74–0.89), an 18% reduction in low high-density lipoprotein cholesterol (HDL-C) (OR 0.82; 95%CI, 0.76–0.89), and an 18% reduction in dyslipidemia (OR 0.82; 95%CI, 0.75–0.91). No significant association was found between a high vs a low level of serum 25-hydroxyvitamin D and risk of high low-density lipoprotein cholesterol (LDL-C) levels (OR 0.86; 95%CI, 0.62–1.19) or hypercholesterolemia (OR 1.03; 95%CI, 0.93–1.15). Dose-response analyses demonstrated that each 10 ng/mL increase in the serum 25-hydroxyvitamin D level was linked, respectively, to a 7% (OR 0.93;95%CI, 0.85–1.02), a 3% (OR 0.97; 95%CI, 0.90–1.05), and a 4% (OR 0.96; 95%CI, 0.92–1.00) marginally significant decrease in the odds of hypertriglyceridemia, low HDL-C, and dyslipidemia. Conclusion Higher serum 25-hydroxyvitamin D levels are associated with significant reductions in the odds of hypertriglyceridemia, low HDL-C, and dyslipidemia in a dose-response trend. Systematic Review Registration PROSPERO registration no. CRD42021219484.

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Vitamin D Deficiency and Cognitive Dysfunction

Moon

Han

2012

Dement Neurocognitive Disord

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Vitamin D is not a true vitamin but a fat-soluble steroid prohormone that has long been known for its important and diverse role in the biological system. Many studies have revealed that vitamin D deficiency is linked with an increased risk of autoimmune diseases, cardiovascular diseases, cancers, type II diabetes and infectious diseases. Vitamin D3 is transformed to its active form, 1, 25-dihydroxyvitamin D3, through metabolisms in the liver and kidney. 1, 25-dihydroxyvitamin D3 interacts with its vitamin D receptor, and the brain is now known to have vitamin D receptors and 1α-hydroxylase. Several lines of evidences suggest vitamin D deficiency is associated with cognitive impairment and dementia, however, its position in cognitive function is still in its infancy. Vitamin D deficiency is a reversible condition and can be easily treated with supplements. Randomized controlled trials of vitamin D supplementation in patients with neurodegenerative conditions are needed.

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Relationship between Serum 25-hydroxyvitamin D Concentration and the Risks of Metabolic Syndrome in Premenopausal and Postmenopausal Women

Cited by 7 publications

References 28 publications

Effect of Sunlight Exposure on Serum 25-Hydroxyvitamin D Concentration in Women with Vitamin D Deficiency: Using Ambulatory Lux Meter and Sunlight Exposure Questionnaire

Effect of Sunlight Exposure on Serum 25-Hydroxyvitamin D Concentration in Women with Vitamin D Deficiency: Using Ambulatory Lux Meter and Sunlight Exposure Questionnaire

Serum 25-hydroxyvitamin D levels and dyslipidemia: a systematic review and dose-response meta-analysis of epidemiologic studies

Vitamin D Deficiency and Cognitive Dysfunction

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