Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa

Tavilani, Heidar; Goodarzi, Mohamad Taghi; Doosti, Mahmood; Vaisi-Raygani, Asad; Hassanzadeh, Taghi; Salimi, Saeedeh; Joshaghani, Hamidreza

doi:10.1016/s1472-6483(10)60478-6

Cited by 45 publications

(38 citation statements)

References 52 publications

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“…These findings are in accordance with the study of Murawski et al [34]. It must be emphasized that SOD seminal plasma provides protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples [35,36]. The results of other studies, however, indicate that SOD activity in seminal plasma is lower in men with normozoospermia than in men with pathological spermiogram [37,38].…”

Section: Discussionsupporting

confidence: 90%

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Marzec-Wróblewska

Kamiński

Łakota

et al. 2010

Biol Trace Elem Res

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The aim of the present study was to measure zinc (Zn) and iron (Fe) concentration in human semen and superoxide dismutase (SOD) activity in seminal plasma and correlate the results with sperm quality. Semen samples were obtained from men (N = 168) undergoing routine infertility evaluation. The study design included two groups based on the ejaculate parameters. Group I (n = 39) consisted of males with normal ejaculate (normozoospermia), and group II (n = 129) consisted of males with pathological spermiogram. Seminal Zn and Fe were measured in 162 samples (group I, n = 38; group II, n = 124) and SOD activity in 149 samples (group I, n = 37; group II, n = 112). Correlations were found between SOD activity and Fe and Zn concentration, and between Fe and Zn concentration. SOD activity was negatively associated with volume of semen and positively associated with rapid progressive motility, nonprogressive motility, and concentration. Negative correlation was stated between Fe concentration and normal morphology. Mean SOD activity in seminal plasma of semen from men of group I was higher than in seminal plasma of semen from men of group II. Fe concentration was higher in teratozoospermic males than in males with normal morphology of spermatozoa in group II. Our results suggest that Fe may influence spermatozoa morphology.

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Section: Discussionsupporting

confidence: 90%

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Marzec-Wróblewska

Kamiński

Łakota

et al. 2010

Biol Trace Elem Res

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“…It must be emphasized that SOD seminal plasma provides protection against lipid peroxidation of phospholipid and phospholipid-bound fatty acids in normozoospermic samples [27]. However, our results are in discordance with others who found no significant difference of seminal plasma SOD activity between men with normozoospermia and those with pathological spermiogram [28,29].…”

Section: Citationcontrasting

confidence: 87%

Evaluation of Seminal Plasma Antioxidants and Serum Male Hormones Status in Infertile Patients with Unbalanced Chromosomal Abnormalities

Ali¹,

Mahdi²,

Ajina³

et al. 2018

Biol Med

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Background: Male infertility appears to be a major clinical problem among men of reproductive age in all societies. Idiopathic male infertility is considered to be a multifactorial disorder affected by genetic, environmental, and hormonal factors. Oxidative stress seems to stand out as one of the underlying mechanisms. In this context, we aimed to evaluate seminal plasma antioxidants SOD (superoxide dismutase), GPx (glutathione peroxidase), CAT (catalase) and zinc levels, hormone levels, and semen parameters in fertile donors and patients with unbalanced chromosomal abnormalities.

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“…We have previously shown that semen lipid peroxidation differs in fertile and infertile males [Tavilani et al 2005;Tavilani et al 2008]. In the present study again we showed an increased level of plasma MDA (a stable product of lipid peroxidation) in the infertile group compared with fertile men, while a lower activity of plasma paraoxonase has been observed in infertile men as compared to fertile individuals.…”

Section: Pon1 Genotypessupporting

confidence: 76%

Genotype and phenotype frequencies of paraoxonase 1 in fertile and infertile men

Tavilani

Fattahi

Esfahani

et al. 2014

Systems Biology in Reproductive Medicine

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Paraoxonase1 (PON1) is a glycoprotein associated with high density lipoprotein and has antioxidant activity. The impact of PON1 in various stages of spermatogenesis has also been suggested. This study was aimed to investigate frequencies of phenotypes and Q192R genotypes of PON1 in fertile and infertile males. Q192R variants of PON1 were determined in 150 fertile and 150 infertile men using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Plasma arylesterase and paraoxonase activities were detected by spectrophotometry and malondialdehyde (MDA) level was measured using thiobarbituric acid. Our results showed no significant difference in the distribution of PON1 genotypes and alleles between fertile and infertile groups. However morphology and motility of sperm were associated with various genotypes of PON1. The number of fertile males with the BB phenotype (high activity) was significantly higher than that of infertile males, whereas the number of individuals with the AB phenotype (moderate activity) was statistically higher in infertile men compared with the fertile group. Additionally, MDA and arylesterase activity levels were significantly higher in infertile subjects compared with fertile men. We speculate that the low activity of PON1 can be a risk factor for male infertility probably due to a decrease in antioxidant activity of PON1 and increase in lipid peroxidation.

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Relationship between seminal antioxidant enzymes and the phospholipid and fatty acid composition of spermatozoa

Cited by 45 publications

References 52 publications

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Evaluation of Seminal Plasma Antioxidants and Serum Male Hormones Status in Infertile Patients with Unbalanced Chromosomal Abnormalities

Genotype and phenotype frequencies of paraoxonase 1 in fertile and infertile men

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