Relationship between Selenium and Hematological Markers in Young Adults with Normal Weight or Overweight/Obesity

Larvie, Doreen; Doherty, Jeanne; Donati, George L.; Armah, Seth M.

doi:10.3390/antiox8100463

Cited by 25 publications

(18 citation statements)

References 39 publications

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“…The fact that these pathologies exhibit oxidative stress and inflammation along with endothelium dysfunction and low Se level ( 93 – 97 ), and the relationships described above between Se and RNA viruses suggest a possible link between SARS-CoV-2 infection and Se.…”

Section: Potential Relationship Between Covid-19 Outcome and Host Selmentioning

confidence: 99%

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Hiffler¹,

Rakotoambinina

2020

Front. Nutr.

104

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SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium (Se), a natural trace element, has a key and complex role in the immune system. It is well-documented that Se deficiency is associated with higher susceptibility to RNA viral infections and more severe disease outcome. In this article, we firstly present evidence on how Se deficiency promotes mutations, replication and virulence of RNA viruses. Next, we review how Se might be beneficial via restoration of host antioxidant capacity, reduction of apoptosis and endothelial cell damages as well as platelet aggregation. It also appears that low Se status is a common finding in conditions considered at risk of severe COVID-19, especially in the elderly. Finally, we present a rationale for Se use at different stages of COVID-19. Se has been overlooked but may have a significant place in COVID-19 spectrum management, particularly in vulnerable elderly, and might represent a game changer in the global response to COVID-19.

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Section: Potential Relationship Between Covid-19 Outcome and Host Selmentioning

confidence: 99%

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Hiffler¹,

Rakotoambinina

2020

Front. Nutr.

104

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“…Oliveira ARS, Cruz KJC, Morais JBS, Santos LR, Melo SRS and Fontenelle LC have participated to the redaction and the review of the manuscript; Oliveira ARS, Cruz KJC, Morais JBS, Santos LR, Melo SRS, Fontenelle LC, Santos GS, Maia CSC, Araujo COD and Mendes IL have participated to generation, collection, assembly, analysis and/or interpretation of data; Henriques GS, Silva VC and Marreiro DN had supervised the paper, participated in the redaction and the review of the paper. Ana R. Soares de Oliveira 1 Kyria Jayanne Clímaco Cruz 1 Jennifer Beatriz Silva Morais 1 Loanne Rocha Dos Santos 1 Stéfany Rodrigues de Sousa Melo 1 Larissa C. Fontenelle 1 Gustavo Santos de Sousa 2 Carla Soraya Costa Maia 3 Camilla Oliveira Duarte de Araújo 3 Islanne Leal Mendes 1 Gilberto Simeone Henriques 4 Vladimir Costa Silva 5 Dilina do Nascimento Marreiro…”

Section: Conflict Of Interestmentioning

confidence: 99%

Selenium status and oxidative stress in obese: Influence of adiposity

Oliveira

Cruz

Morais

et al. 2021

Eur J Clin Investigation

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Background: Selenium deficiency appears to limit antioxidant defense in obese individuals. This study evaluated the association between adiposity indices, selenium status, and oxidative stress in obese women. Methods: This was a cross-sectional study involving 139 women who were divided into the following two groups: the case group (obese women, n = 63) and the control group (normal-weight women, n = 76). Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Body weight, height, waist circumference, hip circumference and neck circumference were measured. Body mass index, waist/height ratio, conicity index, body fat index, body adiposity index, body circularity index, and visceral adiposity index were calculated. Plasma levels of thiobarbituric acid reactive substances were determined. The erythrocyte glutathione peroxidase activity was determined using an automatic biochemical analyzer and Ransel kit. Results: Obese women had selenium deficiency characterized by reduction in plasma and erythrocyte concentrations (P < .001). The urinary selenium excretion was higher in the case group compared to the control group (P < .001).Adiposity indices values and plasma concentrations of thiobarbituric acid reactive substances were significantly elevated in obese women (P < .001). There was a significant association between adiposity indices and selenium status (P < .001), and between erythrocyte selenium and erythrocyte glutathione peroxidase activity (P < .001). Conclusion:Obese women evaluated in the study have reduced plasma and erythrocyte concentrations of selenium and an increased urinary excretion of selenium. The correlation analysis reveals an association between intra-abdominal fat accumulation and selenium metabolism and oxidative stress.

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“…Accordingly, the increase in GPx activity could be the result of the decline in adipose tissue. In the context of obesity being regularly associated with chronic inflammation [43], the enhanced level of GPx activity and SELENOP content could contribute to the prediction of inflammation, as a study in young adults recently demonstrated the inverse relationship between selenoproteins and hepcidin, a protein of iron homeostasis and an inflammation marker [44]. It also remains unclear why the SELENOP concentration rises during the study, while serum Se drops.…”

Section: Discussionmentioning

confidence: 99%

Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study

et al. 2020

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Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se.

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Relationship between Selenium and Hematological Markers in Young Adults with Normal Weight or Overweight/Obesity

Cited by 25 publications

References 39 publications

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Selenium status and oxidative stress in obese: Influence of adiposity

Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study

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