Relationship between secretion of the Anton blood group antigen in saliva and adherence of to oropharynx epithelial cells

Vanalphen, L; Vanham, M; Geelenvandenbroek, L; Pieters, Toine

doi:10.1016/0378-1097(89)90258-9

Cited by 4 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H. influenzae strains agglutinated true Lu(aϪbϪ) red cells, which have normal Indian/CD44 expression, but not In(Lu) and cord red cells, which have suppressed CD44 expression (672). CD44 is present in saliva, which was reported to possess variable quantities of AnWj (676). Moreover, salivary AnWj levels were noted to vary relative to AnWj expression on the oral epithelium (676,677).…”

Section: Haemophilus Influenzae and Anwj Antigenmentioning

confidence: 98%

“…CD44 is present in saliva, which was reported to possess variable quantities of AnWj (676). Moreover, salivary AnWj levels were noted to vary relative to AnWj expression on the oral epithelium (676,677). CD44 levels are usually quite low in saliva but can be increased with smoking, periodontal disease, oral dysplasia, and cancer due to higher CD44 expression levels on buccal epithelium (678,679).…”

Section: Haemophilus Influenzae and Anwj Antigenmentioning

confidence: 99%

See 1 more Smart Citation

Blood Groups in Infection and Host Susceptibility

2015

View full text Add to dashboard Cite

SUMMARY Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.

show abstract

Section: Haemophilus Influenzae and Anwj Antigenmentioning

confidence: 98%

Section: Haemophilus Influenzae and Anwj Antigenmentioning

confidence: 99%

Blood Groups in Infection and Host Susceptibility

2015

View full text Add to dashboard Cite

show abstract

“…We have observed greater binding of N. gonorrhoeae to uroepithelial cells from young women of blood group B compared with cells from those of group A [28]. There is also evidence that the Anton antigen is one of the receptors for H. influenzae [33,34], and Lewis " appears to be one of the receptors for some candida isolates [35,36].…”

Section: The Abo or Lewis Antigens Are Re-ceptors For Adhesins On Sommentioning

confidence: 99%

The role of ABO blood groups and secretor status in host defences

Blackwell

1989

FEMS Microbiology Letters

View full text Add to dashboard Cite

Epidemiological studies on the associations between ABO blood group antigens, secretor status and susceptibility to infectious agents are summarized. Evidence for association of non‐secretion with some autoimmune diseases for which infectious aetiologies have been proposed is also given. Several hypothesis are proposed to explain the host‐parasite interactions underlying the epidemiological observations, and evidence to support or refute them is presented.

show abstract

“…2 The AnWj antigen acts as the receptor for Haemophilus influenzae. 3,4 RBCs of newborns do not or weakly express the AnWj antigen. Transition from AnWj-negative to AnWj-positive phenotype occurs 3-46 days after birth and is completed within 24-48 hours.…”

Section: Introductionmentioning

confidence: 96%

“…AnWj is thought to be carried on the CD44 proteoglycan and possibly resides on the glycosylated region encoded by exons 5 and 15 . The AnWj antigen acts as the receptor for Haemophilus influenzae . RBCs of newborns do not or weakly express the AnWj antigen.…”

Section: Introductionmentioning

confidence: 99%