Relationship Between SCUBE1 Levels and Echocardiography and Electrocardiography Findings and Epicardial Adipose Tissue/Carotid Intima-Media Thickness in Patients Receiving Renal Replacement Therapy

Ayan, Hatice; Akıllı, Rabia Eker; Kaya, Bülent; Paydaş, Saime; Kara, Ertan; Cüreoğlu, Aslıgül

doi:10.6002/ect.mesot2018.p58

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…In our study, SCUBE-1 (in both plasma and pericardial fluid samples) levels did not differ in patients with left ventricular dysfunction. Similar findings are supported by a recent study in renal transplant patients (19). There may be several reasons for this.…”

Section: Discussionsupporting

confidence: 90%

“…With all its known properties, SCUBE-1 is one of the first molecules thought to be effective on cardiac damage and cardiac remodeling. To the best of our knowledge, there are very few studies in the literature investigating the relationship between ventricular functions and SCUBE-1 (19). Although not fully understood, the increase in pericardial fluid is thought to be associated with raised right atrial pressures, which cannot be prevented in patients with low ejection fraction (20).…”

Section: Discussionmentioning

confidence: 99%

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Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Kankılıç¹,

Karahan²,

Demirtaş³

et al. 2021

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 1(SCUBE-1) is a cell surface protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the relationship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent coronary artery bypass surgery. Materials and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dysfunction markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups. Results: Statistical differences were observed in LVDs, IVSd, neutrophil, RBC, CK-MB, troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05). Conclusions: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Kankılıç¹,

Karahan²,

Demirtaş³

et al. 2021

Harran Üniversitesi Tıp Fakültesi Dergisi

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“…PF is potentially related to EF as both exhibit mesothelial layers like visceral organs enriched in white adipose tissue progenitors which produce adipocytes ( 12 , 53 ). This finding bolsters the hypothesis of PF as a risk predictor for CVD in the renal-affected population, and likewise, EF has been considered a CVD risk factor that predicts cardiac dysfunction in CKD patients ( 48 , 49 ). Regarding this latter proposal, these adipose tissues are linked to proven cardiovascular indicators such as carotid intima-media thickness and vascular calcifications indexes ( 4 , 45 , 52 ), and they also express browning fat markers with interactions between both tissues through complex endocrine pathways with differential behaviors to those observed in other adipose tissues ( 54 – 56 ).…”

Section: Organ-specific Fat As Causative Factor Of Cardiorenal Diseasesupporting

confidence: 69%

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

et al. 2021

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There is a growing interest in the potential role of adipose tissues in cardiac and renal pathophysiology, and determining the mechanisms by which fat compartments around the heart and kidneys influence cardiovascular disease is of clinical importance in both general and high-risk populations. Epicardial fat and perirenal fat have been associated with adverse outcomes in chronic kidney disease (CKD) patients. Epicardial fat is a rich source of free fatty acids and is capable of secreting inflammatory and pro-atherogenic cytokines that promote atherosclerosis through a local paracrine effect. Recent evidence has demonstrated that perirenal fat has a closer correlation with kidney diseases than other visceral fat deposits in obesity or metabolic disturbances. Moreover, perirenal fat has been reported as an independent risk factor for CKD progression and even associated with cardiorenal dysfunction. Accordingly, these forms of organ-specific fat deposits may act as a connecter between vascular and cardiorenal disease. This review explores the possible links between epicardial and perirenal fat and its significant role as a modulator of cardiorenal dysfunction in CKD patients.

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Epicardial adipose tissue in patients with chronic kidney disease: a meta-analysis study and trial sequential analysis

et al. 2020

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Relationship Between SCUBE1 Levels and Echocardiography and Electrocardiography Findings and Epicardial Adipose Tissue/Carotid Intima-Media Thickness in Patients Receiving Renal Replacement Therapy

Cited by 5 publications

References 18 publications

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

Epicardial adipose tissue in patients with chronic kidney disease: a meta-analysis study and trial sequential analysis

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