Relationship Between Scleral Thickness and Choroidal Structure in Central Serous Chorioretinopathy

Abstract

Purpose Central serous chorioretinopathy (CSC) is a retinal disorder characterized by serous retinal detachment with or without pigment epithelial detachment in the posterior pole of the eye. We aimed to elucidate the relationship between scleral thickness and choroidal structure in CSC eyes. Methods This single-center retrospective study included 111 eyes of 111 CSC patients. Using swept-source optical coherence tomography, the horizontal cross-sectional images of the posterior choroid were converted to binary images by semiautomated software. The luminal and stromal areas of the choroid were measured, and the luminal/stromal (L/S) ratios of the whole choroid (WC), inner choroid, and outer choroid (OC) at 1500 µm, 3000 µm, and 7500 µm ranges centered on the fovea were calculated. Correlations of L/S ratio and age, spherical equivalent, axial length, subfoveal choroidal thickness (SCT), and scleral thickness were determined. Scleral thickness was measured vertically, 6 mm posterior to the scleral spur in four directions. Results SCT and mean scleral thickness were significantly positively correlated with the L/S ratio in all ranges of WC and OC. Multiple regression analysis found that SCT and mean scleral thickness were significantly correlated with the L/S ratio, and the strength of correlation of mean scleral thickness (WC: 0.386, P < 0.001; OC: 0.391, P < 0.001) was greater than that of SCT (WC: 0.368, P < 0.001; OC: 0.383, P < 0.001) in 7500 µm range. Conclusions Thick sclera appeared to play a role in an increase in the luminal component of the posterior choroid in CSC eyes.

Biomechanical properties measured with dynamic Scheimpflug analyzer in central serous chorioretinopathy

“…This is because we found a large variation in rectus muscle attachment sites, with some anterior to 6 mm and others posterior to 6 mm. However, our method revealed that AST in CSCR eyes was higher than normal control eyes, replicating results of previous studies [ 7 , 16 , 17 ]. Third, AST has limited correlation with scleral thickness around the vortex vein, which is relevant in terms of the venous overload hypothesis.…”

“…Anteriorly, the sclera was distinguished from the hyporeflective rectus muscles; posteriorly, the sclera was distinguished from the choroid appearing as a hyporeflective band. Previous studies [ 7 , 16 , 17 ] have used a constant distance from the scleral spur as the measurement point for AST. However, due to the variability in muscle attachment sites and the abrupt change in scleral thickness at these sites, we adjusted our measurement locations.…”

Vortex Veins in Eyes With Pachychoroid Spectrum Disorders Evaluated by the Adjusted Reverse 3-Dimensional Projection Model

“…As the cause of this regional difference is not clear from the present cross sectional study, future prospective studies on the development of VVA in childhood are needed. In addition, scleral thickness was not associated with the running patterns of Haller's vessels and was positively correlated with choroidal thickness, 27 , 37 whereas the malposition of the VVA was associated with the running patterns of Haller's vessels and not with choroidal thickness. Thus, the sclera and the VVA may have different relationships with the choroid.…”

Scleral changes in systemic lupus erythematosus patients using swept source optical coherence tomography

“…It excels in demarcating the boundaries of anterior segment structures compared to SD-OCT (20). A few recent studies successfully measured scleral thickness in different study groups with the help of SS-OCT (21)(22)(23). However, to our knowledge, no study has yet assessed scleral thickness in SLE patients utilizing SS-OCT.…”