Relationship Between Retinol-Binding Protein-4/Adiponectin and Leptin/Adiponectin Ratios with Insulin Resistance and Inflammation

Abstract

Hence it appears that whereas both the leptin/adiponectin and RBP4/adiponectin ratios correlate with inflammation, only the RBP4/adiponectin ratio was significantly increased in metabolic syndrome and would be more useful to predict CVD, especially in metabolic syndrome.

WITHDRAWN: Relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

“…Jialal and cols. suggested that serum irisin and RBP-4 levels would be independent predictors of CVD in diabetes (30). We think that RBP-4 is significantly associated with nearly all components of MetS and inflammation.…”

“…Many authors found that RBP-4 levels were associated with MetS parameters and HOMA-IR, the duration of diabetes and carotid atherosclerosis as determined by CIMT (26)(27)(28)(29). There are conflicting results about the association of RBP-4 and CRP levels, probably due to methodological differences (30,31). Jialal and cols.…”

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

“…Thus, negatively regulating the expression of the adiponectin gene leads to low plasma concentrations of adiponectin and so susceptibility to T2DM and obesity (Suriyaprom et al, 2014). In addition, numerous studies reported the association of the minor allele G of rs266729 with low plasma adiponectin concentrations (Jiala et al, 2014;de Haan et al, 2014). Unfortunately adiponectin plasma levels could not be determined in the current study due to logistic difficulties.…”

Оментин-1 У Хворих На Цукровий Дiабет 2 Типу: Зв'язок З Атерогенезом

“…Викликає iнтерес високозначуща оберне-на асоцiацiя цього адипокiну з таким преди-ктором кардiоваскулярної хвороби, особли-во за наявностi метаболiчного синдрому, як спiввiдношення ретинол-зв'язуючий проте-їн-4/адипонектин (r = -0,338; р = 0,003) [22]. В той же час була вiдзначена тiсна пряма кореляцiя з проатерогенним остеопротегери-ном (r = 0,307; р = 0,009), що являє собою глi-копротеїн iз суперродини ФНП-рецепторiв, який синтезується у клiтинах кiсток, ен-дотелiю, у гладенько-м'язових клiтинах та iн.…”