Relationship between Retinal Thickness Profiles and Visual Outcomes in Young Adults Born Extremely Preterm

Balasubramanian, Siva; Beckmann, Joanne; Mehta, Hemal; Sadda, Srinivas R; Chanwimol, Karntida; Nassisi, Marco; Tsui, Irena; Marlow, Neil; Jain, Saurabh

doi:10.1016/j.ophtha.2018.07.030

Cited by 30 publications

(45 citation statements)

References 29 publications

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“…The finding that only GA significantly influences CFT, supports the view that early birth interferes with inner retinal migration at the fovea, despite continuing development of the fovea. The EPICure@19 Study 44 has reported a correlation between increased retinal thickness with a reduction in best-corrected visual acuity in adults born extremely preterm. The best-corrected visual acuity reduction was found to be similar in untreated ROP and non-ROP, suggesting that prematurity and not presence of ROP per se, has an impact on retinal thickness and vision.…”

Section: Discussionmentioning

confidence: 99%

Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Anwar

Nath

Patel

et al. 2020

Retina

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Purpose: To investigate dynamic foveal morphology with postmenstrual age, in preterm infants with and without retinopathy of prematurity using hand-held optical coherence tomography, adjusting for gestational age (GA) and birthweight (BW). Methods: Prospective mixed cross-sectional/longitudinal observational study of 87 participants (23-36 weeks GA; n = 30 with, n = 57 without retinopathy of prematurity) using hand-held optical coherence tomography images (n = 278) acquired between 31 weeks and 44 weeks postmenstrual age excluding treated retinopathy of prematurity. Measurements included foveal width, area, depth, central foveal thickness, maximum slope, and parafoveal retinal thickness at 1,000 mm nasal and temporal to the central fovea. Results: Retinopathy of prematurity was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (P , 0.005), depth (P # 0.001), and slope (P , 0.01), although central foveal thickness (P = 0.007) and parafoveal retinal thickness (P , 0.001) correlated with GA, but not with BW. Conclusion: Foveal width is independent of GA and BW with potential in retinopathy of prematurity screening assessment using hand-held optical coherence tomography. Foveal morphology could be graded in prematurity during development, with possible implications for future management of preterm infants.

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Section: Discussionmentioning

confidence: 99%

Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Anwar

Nath

Patel

et al. 2020

Retina

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“…Cheong et al (2017) 14 reported CP rates for the Victorian Infant Collaborative Study cohort of 11 to 14% in children born extremely preterm (22)(23)(24)(25)(26)(27) in three eras of recruitment, 1991 to 1992; 1997; and 2005, with no significant change over time in CP rates and also in the proportion of those with moderate-severe CP (6-7%). These data, and the data from the two EPIcure cohorts, are consistent with the SCPE and Australian CP Register data, which do not (yet) show a decreasing prevalence of CP in the extremely low BW group.…”

Section: Neuromotor Function and Development Of Neuromotor Function Imentioning

confidence: 99%

“…Interestingly, no significant associations between GA at birth and visual impairment were seen when treatment-requiring ROP was adjusted for; in contrast, an association remained between refractive errors and GA at birth. 25 Adult (at the age of 19 years) outcome data for the EPIcure cohort 26 show that extremely preterm birth influences fovea maturation and visual function into early adult life, and that early treatment for ROP is associated with poorer visual acuity at adult age.…”

Section: Hearing and Visual Impairmentmentioning

confidence: 99%

“…Similar to the Bavarian cohort, for the Stockholm Neonatal Project (SNP) cohort, where preterm participants (and <1,500 g BW and <37 wGA; the majority of which were born <27 wGA) and term born controls were assessed at the age of 5.5 and 18 years, overall stability of IQ and executive function over time was seen, 48,61 with developmental trajectories being fairly well established at preschool age for the majority of the preterm born participants. Lundequist et al (2015) 48 reported that the extremely preterm group (22)(23)(24)(25)(26)(27) wGA) performed poorest on all the cognitive tests, in particular, on executive function tasks. Compared with results at the age of 5.5 years, the effect had not diminished but rather strengthened over time.…”

Section: Longitudinal Characterizationmentioning

confidence: 99%

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Young Adult Motor, Sensory, and Cognitive Outcomes and Longitudinal Development after Very and Extremely Preterm Birth

Vollmer

Stålnacke

2019

Neuropediatrics

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In this narrative review, we report on adult outcomes after very (before 32 weeks of gestation [wGA]) and extremely (before 28 wGA) preterm birth, with a focus on neuromotor function, neurosensory impairment, general cognitive abilities, executive function, and attentional abilities, all of which are important for academic progress, peer relationships, and participation. Longitudinal development from childhood to adulthood is described. Preterm born individuals have a higher risk for impairment of general cognitive abilities, executive function, attention, and neuromotor abilities well into adulthood, with, however, considerable variability in outcomes. Differences between individuals born preterm and their term born peers persist. Long-term outcomes of general cognitive ability can be predicted with some degree of certainty from childhood assessments: those who perform poor on early childhood age assessments very likely will not catch up, whereas those who perform within the normal range on early assessments sometimes accelerate their development relative to term born peers. This appears similar for executive function and attention, although data on trajectories for these functions are somewhat inconsistent. In adulthood, some studies describe poorer educational outcomes, employment, independent living, and/or economic situation compared with term born individuals; however, large proportion of those born preterm report similar self-perceived quality of life.

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“…There are many cohorts for preterm infants overseas, such as the Extreme Premature Infant Cohort at the University College of London, UK (EPICure); 11 the preterm-children cohort in Paris, France (L’Etude épidémiologique sur les petits âges gestationnels (Epipage)); 12 the Project On Preterm and Small-for-gestational-age infants (POPS) in the Netherlands; 13 and the preterm birth infant cohort in Nova Scotia, Canada. 14 These cohorts have been followed up for many years, and many important conclusions have been drawn from the correlation between preterm birth and such factors as pulmonary function, neurodevelopment, learning ability, ASDs and the tendency toward hyperactivity.…”

Section: Introductionmentioning

confidence: 99%

Cohort protocol: Guangzhou High-Risk Infant Cohort study

Han

et al. 2020

BMJ Open

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IntroductionDespite the increase in the survival rate of high-risk infants (HRIs) worldwide, the prevalence of motor and neurodevelopmental sequelae in such newborns has not shown concomitant improvement. Meanwhile, there are few cohorts that explore factors related to the development of HRIs in China. Therefore, the Guangzhou High-Risk Infant Cohort (GHRIC) has been designed to examine the complex relationships among a myriad of factors influencing growth and development in such children.Methods and analysisThe GHRIC study is a prospective cohort study that by the year 2023 will enrol an estimated total of 3000 HRIs from Guangzhou Women and Children’s Medical Center (GWCMC) in Guangzhou, China. This study is designed to assess the growth and cognitive characteristics of HRIs and the risk factors affecting their development and prognoses. Data on risk factors, neurodevelopmental and cognitive-function evaluations, laboratory results, and specimens will be collected and analysed. Information on perinatal and clinical interventions for these infants will also be recorded during regular follow-up visits until age 6.Ethics and disseminationThe protocol for this study has been approved by the Research Ethics Committee of GWCMC, which accepted responsibility for supervising all of the aspects of the study (No. 2017102712). Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the Internet and social media.Trial registration numberChiCTR-EOC-17013236

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Relationship between Retinal Thickness Profiles and Visual Outcomes in Young Adults Born Extremely Preterm

Cited by 30 publications

References 29 publications

Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Potential Utility of Foveal Morphology in Preterm Infants Measured Using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Young Adult Motor, Sensory, and Cognitive Outcomes and Longitudinal Development after Very and Extremely Preterm Birth

Cohort protocol: Guangzhou High-Risk Infant Cohort study

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