Relationship between retinal morphological findings and visual function in age-related macular degeneration

Abstract

Background We aimed to study the retinal morphological findings associated with exudative age-related macular degeneration (AMD) and their association with visual prognosis. Methods We retrospectively reviewed the medical records of 96 consecutive patients (96 eyes) with exudative AMD.

Correlation Between Hyperreflective Foci and Clinical Outcomes in Neovascular Age-Related Macular Degeneration After Switching to Aflibercept

“…Unlike what was seen in our study, they found a positive correlation between SDP reduction and improvement in BCVA (P ¼ 0.006). Contrary to the results of Akagi-Kurashige et al, 28 Framme et al 29 found that the baseline amount of SDPs correlated positively with the increase in BCVA (P ¼ 0.005). They hypothesized that initial large number of HF may indicate a higher grade of inflammation, but the presence of a high number improves the effect of ranibizumab therapy in neovascular AMD, and they concluded that the amount of SDPs could be a predictive factor for the treatment outcome.…”

“…Akagi-Kurashige and associates reported that eyes with HF at baseline had more active CNV and more severe blood-retinal barrier damage. 28 A small percentage of cases without HF in their study (18.7%) had milder CNV and less severe blood-retinal barrier damage, but they did not measure the CNV size. Initial presence of HF in the foveal neurosensory retina was associated with poor final visual acuity in their study.…”

Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration

“…Various studies have examined the structure-function relationship in neovascular AMD, and identified retinal edema, intraretinal cystoid spaces, subretinal fluid (SRF), subretinal hyperreflective material, as well as the outer nuclear layer and the integrity of the ellipsoid zone (previously described as inner segment/outer segment junction) as parameters relevant for VA [8,9,10,11,12,13,14,15,16,17,18,19]. However, the results of those studies were partially contradictory and did not satisfactorily explain the relevance of OCT features for visual function in neovascular AMD.…”

One-Year Outcomes of the Treat-and-Extend Approach with Aflibercept in Age-Related Macular Degeneration: Effects on Typical Choroidal Neovascularization and Retinal Angiomatous Proliferation

“…When analyzing anatomical changes, the different CNV lesion subtypes ( Table 2 ; Fig. 1 ) showed the following SD-OCT characteristics: typical CNV was associated with a high initial CMT (355.8 ± 97.41 μm) and MV (8.05 ± 0.84 cm 3 ), and although the thickness had greatly decreased after 3 and 6 months, it persisted at higher levels than in the RAP subgroup at 12 months (CMT 243.13 ± 53.04 μm). IRF (cystic spaces) and SRF were present in 55 and 79.3% of the eyes, respectively, at baseline and in 10.3 and 3.4% of the eyes at 12 months; ELM and EZ disruption was higher than in the other subtypes, though their length increased over the treatment course.…”

“…Results: BCVA significantly improved from 0.6 ± 0.27 to 0.4 ± 0.34 logMAR. The final mean numbers of injections were 8.03 ± 1.27 and 7.28 ± 0.75 and the numbers of visits 6.5 ± 1.09 and 7.14 ± 1.57 in membrane (ELM), or restoration of the ellipsoid zone (EZ) [2][3][4][5] .…”