Relationship between residence time distribution and forces applied by paddles on powder attrition during the die filling process

Mateo-Ortiz, Daniel; Méndez, Rafael

doi:10.1016/j.powtec.2015.03.015

Cited by 55 publications

(18 citation statements)

References 22 publications

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“…They identified various mechanisms negatively affecting the bulk properties, including overlubrication and abrasion caused by stresses in the feed frame, as well as segregation of blends. Mateo-Ortiz et al numerically investigated possible particle attrition due to the stress applied by the paddles within the feed frame and found rising tangential stress for higher paddle speeds [16]. These findings were in good accordance with results obtained by Mendez et al who found altered particle size distribution after the feed frame passage [14].…”

Section: Powder Flow In Rotary Tablet Pressessupporting

confidence: 73%

“…However, the powder flow through the tablet press in general and the feed frame especially is known to possibly cause several unwanted changes of the powder blend properties, which result in an alteration of tablet-quality defining attributes, e.g., mechanical strength. There have been several recent studies regarding the effect of the feed frame on bulk properties, both experimental [11][12][13][14] as well as computational studies [15][16][17]. They identified various mechanisms negatively affecting the bulk properties, including overlubrication and abrasion caused by stresses in the feed frame, as well as segregation of blends.…”

Section: Powder Flow In Rotary Tablet Pressesmentioning

confidence: 99%

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Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Puckhaber

Eichler²,

Kwade

et al. 2020

Pharmaceutics

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Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and efficient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the residence time distribution (RTD) of two commonly applied excipients (microcrystalline cellulose, MCC; dicalcium phosphate, DCP), which exhibit different flow properties inside rotary tablet presses. To realistically depict the powder flow inside rotary tablet presses, custom-made tracer powder was developed. The applied method was proven to be appropriate as the tracer and bulk powder showed comparable properties. The RTDs of both materials were examined in two differently scaled rotary tablet presses and the influence of process parameters was determined. To analyze RTDs independent of the mass flow, the normalized variance was used to quantify intermixing. Substantial differences between both materials and tablet presses were found. Broader RTDs were measured for the poorer flowing MCC as well as for the production scale press. The obtained results can be used to improve the general understanding of powder flow inside rotary tablet presses and amplify scale-up and continuous production process development.

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Section: Powder Flow In Rotary Tablet Pressessupporting

confidence: 73%

Section: Powder Flow In Rotary Tablet Pressesmentioning

confidence: 99%

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Puckhaber

Eichler²,

Kwade

et al. 2020

Pharmaceutics

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“…Commonly, blends of multiple bulk solids are compressed to tablets in industrial applications. This makes the compression process more complex for homogeneous blends [7], but also brings along the risk that segregation [18], attrition [19,20], dispersion [21][22][23], and (over)mixing play a vital role for the quality of the final product. These mechanisms typically take place before the compression process in the sub-processes of blend preparation [22], feeding [24], and filling of the dies.…”

Section: Introductionmentioning

confidence: 99%

Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes

et al. 2020

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Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low material consumption, and high instrumentation to generate the most possible process understanding. However, their capability of resembling general aspects of rotary press compaction and their precision in simulating or mimicking sub-processes such as feeding and filling need to be systematically studied. The effect of material deformation behavior, blend composition, and feeding on tensile strength and simulation precision as compared with rotary presses of different scales is evaluated in this study. Generally, good simulation performance was found for the studied compaction simulator. Compaction profile-sensitivity was demonstrated for highly visco-plastic materials while shear-sensitivity in feeding was demonstrated for lubricated blends of ductile particles. Strategies for the compensation of both in compaction simulator experiments are presented by careful investigation of the compaction stress over time profiles and introduction of a compaction simulator-adapted shear number approach to account for differences in layout and operation mode between compaction simulator and rotary press, respectively. These approaches support the general aim of this study to provide a more straightforward determination of scaling process parameters between rotary press and compaction simulator and facilitate a quicker and more reliable process transfer.

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“…The major benefit of numerical simulations by DEM lies in the highly detailed results since each and every particle can be tracked within the system [7]. Thereby most numerical studies either focused on the effect of geometry design, process parameters, or micro-mechanical material properties [3,5,6]. Thereby most numerical studies either focused on the effect of geometry design, process parameters, or micro-mechanical material properties [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…However, this benefit comes along with a high computational cost. Only very few considered the fundamental inherence of differently sized particles within pharmaceutical blends [4,6]. Only very few considered the fundamental inherence of differently sized particles within pharmaceutical blends [4,6].…”

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of the Die Filling Process Within a Pharmaceutical Tableting Machine

Hildebrandt

Gopireddy

Scherließ

et al. 2018

Chemie Ingenieur Technik

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One of the main benefits of numerical simulations is the ability to shed light on the underlying physics in unit operations. This advantage was exploited in this work to study the die filling process in a lab-scale pharmaceutical rotary tablet press. The die filling process with emphasis on mass holdup, mass flow rate, tablet mass, and API content in the dies is described in detail. Eventually a design of experiments provides a clear picture on the influence of process conditions and material properties on the tablet mass to improve the process understanding.

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Relationship between residence time distribution and forces applied by paddles on powder attrition during the die filling process

Cited by 55 publications

References 22 publications

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes

Numerical Analysis of the Die Filling Process Within a Pharmaceutical Tableting Machine

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