Relationship Between Renal Function Test Serum and Lipid Profile in Patients with Diabetes Mellitus

Puspitasari,; Aliviameita, Andika

doi:10.1088/1742-6596/1114/1/012011

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The CREA is a more dependable measure of kidney function compared to the BUN because it is less affected by external factors like diet and hydration [ 37 ]. The BUN, a byproduct of protein breakdown created in the liver and excreted by the kidney, which is often used in combination with CREA to evaluate renal function in clinical [ 38 ]. However, it is important to note that BUN content can be influenced by various factors such as protein intake, corticosteroids, gastrointestinal bleeding, and dehydration [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the alpine meadow in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Guo,

Wang,

Zhang

et al. 2024

BMC Microbiol

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Background In this study, we investigated the effects of alpine meadow in different phenological periods on ruminal fermentation, serum biochemical indices, and gastrointestinal tract microbes in grazing yak on the Qinghai-Tibetan Plateau. A total of eighteen female freely grazing yaks with an average age of 3 years old and a body weight of 130 ± 19 kg were selected. According to the plant phenological periods, yaks were randomly allocated to one of three treatments: (1) regreen periods group (RP, n = 6); (2) grassy periods group (GP, n = 6); and (3) hay periods group (HP, n = 6). At the end of the experiment, the blood, rumen fluids, and rectal contents were collected to perform further analysis. Results The concentrations of total volatile fatty acid (TVFA), acetate, glucose (GLU), triglyceride (TG), cholesterol (CHO), high density lipoprotein (HDL), and low density lipoprotein (LDL) were higher in the GP group than in the HP group (P < 0.05). However, compared with the RP and GP groups, the HP group had higher concentrations of isobutyrate, isovalerate, valerate, and creatinine (CREA) (P < 0.05). The abundance of Prevotella in the rumen, and the abundances of Rikenellaceae_RC9_gut_group, Eubacterium_coprostanoligenes_group, and Prevotellaceae_UCG-004 in the gut were higher in the GP group compared with the HP group (P < 0.05). The HP had higher abundance of Eubacterium_coprostanoligenes_group in the rumen as well as the abundances of Romboutsia and Arthrobacter in the gut compared with the RP and GP groups (P < 0.05). Conclusions Based on the results of rumen fermentation, serum biochemical, differential biomarkers, and function prediction, the carbohydrate digestion of grazing yak would be higher with the alpine meadow regreen and grassy due to the gastrointestinal tract microbes. However, the risk of microbe disorders and host inflammation in grazing yak were higher with the alpine meadow wither.

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Section: Discussionmentioning

confidence: 99%

Effects of the alpine meadow in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Guo,

Wang,

Zhang

et al. 2024

BMC Microbiol

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show abstract

“…The CREA is a more dependable measure of kidney function compared to blood urea nitrogen (BUN) because it is less affected by external factors like diet and hydration [36]. The BUN, a byproduct of protein breakdown created in the liver and excreted by the kidney, which is often used in combination with CREA to evaluate renal function in clinical [37].…”

Section: Serum Biochemical Indicesmentioning

confidence: 99%

Effects of the grass in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Guo,

Wang,

Zhang

et al. 2023

Preprint

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Background: In this study, we investigated the effects of grass in different phenological periods on ruminal fermentation, serum biochemical indices, and gastrointestinal tract microbes in grazing yak on the Qinghai-Tibetan Plateau. A total of eighteen female freely grazing yaks with an average age of 3 years old and a body weight of 130 ± 19 kg were selected. According to the plant phenology periods, yaks were randomly allocated to one of three treatments: (1) regreen periods group (RP, n = 6); (2) grassy periods group (GP, n = 6); (3) hay periods group (HP, n = 6). At the end of the experiment, the blood, rumen fluids, and rectal contents were collected to perform further analysis. Results: Yak in the GP group increased the concentration of total volatile fatty acid (TVFA), acetate, urea acid (UA), glucose (GLU), triglyceride (TG), cholesterol (CHO), high density lipoprotein (HDL), low density lipoprotein (LDL), the abundance of Prevotella in the rumen, and the abundances of Rikenellaceae_RC9_gut_group, Eubacterium_coprostanoligenes_group, and Prevotellaceae_UCG-004 in the gut (P < 0.05). However, yak in the HP group increased the concentrations of isobutyrate, isovalerate, valerate, creatinine (CREA), the abundance of Eubacterium_coprostanoligenes_group in the rumen, and the abundances of Romboutsia and Arthrobacterin the gut (P < 0.05). Conclusions: Based on the results of rumen fermentation, serum biochemical, differential biomarkers, and function prediction, yak increased the digestion of carbohydrates via gastrointestinal tract microbes with the grass regreen and grassy. However, the gastrointestinal tract of yaks increased the risk of microbe disorders and host inflammation with the grass wither.

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Risk Factors Associated with Diabetic Nephropathy and Their Clinical Significance

Чернышов¹,

Несен²,

Семеновых³

et al. 2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to highlight the most studied risk factors associated with the development and/or progression of diabetic nephropathy, with an emphasis on some important aspects that should be kept in mind by the physician. Materials and methods. Research materials are publications of national and foreign authors. The methods used were: system approach and system theoretical retrospective analysis of selected materials; generalization; medical and statistical method. Results and discussion. Timely diagnostics of diabetic nephropathy and elimination of risk factors of its development and progression are emphasized to be a difficult task of clinics of internal diseases particularly in conditions when amount of these risk factors is constantly growing. The most investigated risk factors associated with development and progression of diabetic nephropathy such as age, arterial hypertension, disorders of carbohydrate and lipid exchange, proteinuria are discussed in the article. Some peculiarities of correction of metabolic risk factors such as hyperglycemia and dyslipidemia as well as hemodynamic risk factors such as arterial hypertension and intraglomerular hypertension participated in development and progression of diabetic nephropathy are discussed with consideration of acting recommendations. Some aged and gender peculiarities of change of glomerular filtration rate as well as a role of arterial hypertension in progression of diabetic nephropathy through albuminuria are considered. A significance of glycosylated hemoglobin level as an independent risk factors of microalbuminuria is demonstrated. A role of secondary lipid exchange disorders due to type 2 diabetes mellitus in reduction of glomerular filtration rate and elevation of albumin/creatinine ratio as well as albuminuria presence is emphasized. A necessity of urinal detection of nephrin and podocin levels for an early diagnostics of diabetic nephropathy and monitoring of renal glomerular dysfunction in diabetes mellitus is discussed. Some risk factors related to appearance of albuminuria as well as association of albuminuria and proteinuria with glomerular and tubular structural changes in kidney are considered. A clinical significance of albumin/creatinine ratio calculation as an alternative to daily urinal protein concentration measuring for diabetic nephropathy screening is emphasized. Some risk factors related to close positive correlation with this ratio are considered. A role of genetic factors in the development of diabetic nephropathy with a participation of known today some genes candidates and a necessity of genealogical anamnesis definition to reveal a patient’s susceptibility to development of diabetic nephropathy is discussed. Conclusion. The contemporary recommendations for control of glycemia, correction of dyslipidemia and arterial hypertension which allow significantly reduce a risk of kidney impairment in diabetes mellitus or inhibit a progression of diabetic nephropathy in patients with albuminuria and proteinuria are given. A significance of detailed investigation of principles of development and progression of diabetic nephropathy for collaboration of effective diagnostic, treatment and preventive measures is emphasized

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Relationship Between Renal Function Test Serum and Lipid Profile in Patients with Diabetes Mellitus

Cited by 4 publications

References 9 publications

Effects of the alpine meadow in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Effects of the alpine meadow in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Effects of the grass in different phenological periods on rumen fermentation and gastrointestinal tract bacteria community in grazing yak on the Qinghai-Tibetan Plateau

Risk Factors Associated with Diabetic Nephropathy and Their Clinical Significance

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