Relationship between red cell distribution width/albumin ratio and carotid plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China

Huang, Mengnan; Liu, Fanfan; Li, Zhu; Liu, Yijia; Su, Jinyu; Ma, Mei; He, Yuanyuan; Bu, Huaien; Gao, Shan; Wang, Hongwu; Yu, Chunquan

doi:10.1186/s12933-023-01768-w

Cited by 11 publications

(16 citation statements)

References 51 publications

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“…Huang M, et al found that RAR is signi cantly related with carotid plaques in patients with coronary heart disease [12]. A study of 3042 patients with sepsis and AF indicated that RAR was strongly independently associated with the risk of all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The RAR, a combination of red cell distribution width and albumin, is a novel index of in ammation. Prior researches have suggested that RAR may be helpful in assessing the outcomes in of acute biliary pancreatitis attacks [10], 60-day mortality in patients with acute respiratory distress syndrome [11], and carotid plaques in patients with CHD [12]. However, the association of RAR and AF has not been clari ed in prior studies.…”

Section: Introductionmentioning

confidence: 99%

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Red cell distribution width to albumin ratio is a risk factor for atrial fibrillation in general population

Song

2023

Preprint

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Background: Red cell distribution width to albumin ratio (RAR) has been demonstrated to be associated with the risk of cardiovascular diseases. However, it is still unknown whether the RAR affects atrial fibrillation (AF) . Therefore, this study aimed to investigate the association between RAR and AF in general population. Methods: A total of 2436 participants were retrospectively enrolled. Red cell distribution width, albumin and other data were collected. AF was confirmed using 12-lead electrocardiogram (ECG) or 24-hour Holter. All participants were divided into four groups according to the RAR values by quartile (Q1, Q2, Q3, Q4). Univariate and multivariate logistic regression were performed to examine the correlation between RAR and AF. Results: Among the 2436 participants, 227 (9.3%) AF cases were observed. The RDW and RAR were significantly higher in AF group than in non-AF group (all P<0.001). Univariate logistic regression showed an positive association between RAR and AF (P<0.001). In multivariate logistic regression, RAR was found to be an independent risk factor of AF after adjusting for confounding factors (OR:2.015, 95%CI:1.315-3.089, P=0.001) . Conclusions: The present study indicated that elevated RAR level was independently correlated with increased risk of AF in general population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Red cell distribution width to albumin ratio is a risk factor for atrial fibrillation in general population

Song

2023

Preprint

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“…As a simple and inexpensive inflammatory indicator, a high level of RAR has been reported to be associated with poor prognosis in various inflammation‐related diseases 11–14,17 . A cohort study based on data from the MIMIC‐III database evaluated RAR's prognostic effect in short‐ and long‐term mortality of patients with HF 12 .…”

Section: Discussionmentioning

confidence: 99%

Association between red blood cell distribution width‐to‐albumin ratio and prognosis in non‐ischaemic heart failure

Zhou,

Tian,

Zhai

et al. 2024

ESC Heart Failure

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AimsRed blood cell distribution width‐to‐albumin ratio (RAR), an innovate biomarker of inflammation, can independently predict adverse cardiovascular outcomes. However, the association between RAR and prognosis in patients with non‐ischaemic heart failure (NIHF) remains unclear.Methods and resultsA total of 2077 NIHF patients admitted to the Heart Failure Care Unit, Fuwai Hospital, were consecutively enrolled from December 2006 to October 2017 in this retrospective study. The primary endpoint was a composite outcome of all‐cause mortality and heart transplantation. The correlation between RAR and the composite outcome was assessed by the Kaplan–Meier survival analysis and the Cox regression analysis. Incremental predictive values and the clinical performance of RAR for all‐cause mortality or heart transplantation were also assessed based on a 12‐variable traditional risk model. The median follow‐up time in this study was 1433 (1341, 1525) days. As the gender no longer satisfied the Cox proportional risk assumption after 1150 days, we set 1095 days as the follow‐up time for analysis. A total of 500 patients reached the composite outcome. Multivariable Cox regression showed that per log2 increase of RAR was significantly associated with a 132.9% [hazard ratio 2.329, 95% confidence interval (CI) 1.677–3.237, P < 0.001] increased risk of all‐cause mortality or heart transplantation. Better model discrimination [concordance index: 0.766 (95% CI 0.754–0.778) vs. 0.758 (95% CI 0.746–0.770), P < 0.001], calibration (Akaike information criterion: 1487.3 vs. 1495.74; Bayesian information criterion: 1566.25 vs. 1569.43; Brier score: 1569.43 vs. 1569.43; likelihood ratio test P < 0.001), and reclassification (integrated discrimination improvement: 1.35%, 95% CI 0.63–2.07%, P < 0.001; net reclassification improvement: 13.73%, 95% CI 2.05–27.18%, P = 0.034) were improved after adding RAR to the traditional model (P < 0.001 for all). A higher overall net benefit was also obtained in the threshold risk probability of 20–55%.ConclusionsHigh level of RAR was an independent risk factor of poor outcome in NIHF.

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“…They found that patients in the highest tertile of RAR showed a significantly higher risk of end-stage kidney disease (HR 2.92, 95% CI: 1.44-5.94), all-cause mortality (HR 3.38, 95% CI: 1.81-6.30) and cardiovascular events (HR 2.27, 95% CI: 1.36-3.78), than those in the lowest tertile of RAR. Huang et.al included and analyzed 10267 patients with coronary heart disease in China[32]. After adjusting for confounding factors, they found that elevated RAR was significantly associated with increased risk of carotid plaque formation (OR: 1.23; 95% CI 1.08-1.39), and the association was more significant in women and patients aged < 60 years[32].…”

Section: Discussionmentioning

confidence: 99%

“…Huang et.al included and analyzed 10267 patients with coronary heart disease in China[32]. After adjusting for confounding factors, they found that elevated RAR was significantly associated with increased risk of carotid plaque formation (OR: 1.23; 95% CI 1.08-1.39), and the association was more significant in women and patients aged < 60 years[32]. In summary, previous studies have reported that RAR was a potential risk biomarker for adverse outcomes in various diseases-specific populations.…”

Section: Discussionmentioning

confidence: 99%

Association of red cell distribution width to albumin ratio with risk of all-cause and cause-specific mortality: two prospective cohort studies

Hao,

Jiang,

et al. 2024

Preprint

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Background The red cell distribution width to albumin ratio (RAR) has emerged as a reliable prognostic marker for mortality in various diseases. However, whether RAR is associated with mortality remains unknown in the general population. Objective Explore whether RAR is associated with all-cause and cause-specific mortality, and to elucidate the dose-response relationship between them. Methods This study included 50622 participants aged 18+ years from US National Health and Nutrition Examination Survey (NHANES), and 418950 participants aged 37+ years from UK Biobank. The potential association between RAR and the risk of all-cause and cause-specific mortality was evaluated by Cox proportional hazard models. Restricted cubic spline regressions were applied to estimate the possible nonlinear relationships. Results NHANES documented 7590 deaths over a median follow-up of 9.4 years, and UK Biobank documented 36793 deaths over a median follow-up of 14.5 years. In multivariable analysis, elevated RAR were significantly associated with a higher risk of all-cause mortality (NHANES: hazard ratio [HR]: 1.86, 95% confidence interval [CI]: 1.81-1.93; UK Biobank: HR: 2.01, 95% CI: 1.96-2.06), as well as mortality due to malignant neoplasms, heart disease, cerebrovascular diseases, respiratory diseases, diabetes mellitus, and others in both the two cohorts (all P-value < 0.05). Conclusions Higher baseline RAR was strongly and independently associated with increased risk of all-cause and cause-specific mortality in the general population. RAR was a promising indicator that simply, reliably, and inexpensively accessible for identifying high-risk of mortality in clinical practice.

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Relationship between red cell distribution width/albumin ratio and carotid plaque in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China

Cited by 11 publications

References 51 publications

Red cell distribution width to albumin ratio is a risk factor for atrial fibrillation in general population

Red cell distribution width to albumin ratio is a risk factor for atrial fibrillation in general population

Association between red blood cell distribution width‐to‐albumin ratio and prognosis in non‐ischaemic heart failure

Association of red cell distribution width to albumin ratio with risk of all-cause and cause-specific mortality: two prospective cohort studies

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