Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis

Hu, Bin; Cao, Jinxia; Hu, Yangyang; Qin, Zuoan; Wang, Jun

doi:10.2147/ijgm.s329296

Cited by 2 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Red blood cell distribution width (RDW) is a quantitative parameter that indicates the degree of volume variation in erythroid cells and is customarily used in hematology to help diagnose anemia. [4] Increased RDW levels and adverse cerebrovascular outcomes have received considerable attention in various patient populations. Population-based studies have shown that RDW independently and directly predicts mortality in cardiovascular and other acute and chronic diseases, such as acute myocardial infarction, heart failure, pulmonary hypertension, ischemic stroke, coronavirus disease 2019, acute pancreatitis, and acute kidney injury.…”

Section: The Authors Have No Funding and Conflicts Of Interest To Dis...mentioning

confidence: 99%

Red cell distribution width to total serum calcium ratio and in-hospital mortality risk in patients with acute ischemic stroke: A MIMIC-IV retrospective analysis

Zhang,

Shen,

Zhou

et al. 2024

Medicine

View full text Add to dashboard Cite

We investigated the relationship among red cell distribution width (RDW), to total serum calcium (TSC) ratio (RCR), and in-hospital mortality in patients with acute ischemic stroke (AIS). This study was a retrospective analysis. The data of 2700 AIS patients was retrospectively analyzed from the Medical Information Mart for Intensive Care database (version IV). The main outcome of interest was in-hospital mortality. A Cox proportional hazards regression model was used to determine whether RCR was independently associated with in-hospital mortality. The Kaplan–Meier method was used to plot the survival curves for RCR. Subgroup analyses were performed to measure the mortality across various subgroups. The area under curve (AUC) of receiver operating characteristic curve (ROC) was calculated to ascertain the quality of RCR as a predictor of in-hospital mortality in patients with AIS. In the multivariate analysis, statistically significant differences were identified in age, ethnicity, length of ICU stay, mechanical ventilation, sequential organ failure assessment (SOFA) score, RDW, hemoglobin, RCR, whether taking anticoagulants, hyperlipidemia, and atrial fibrillation (P < .05). A threshold inflection point value of 1.83 was obtained through a two-piecewise regression model. There was a non-linear relationship between RCR and hospital mortality in patients with AIS. The hazard ratio (HR) and the 95% confidence intervals (CI) on the right and left of the inflection point were 0.93 (0.57-1.51; P = .7660) and 2.96 (1.37–6.42; P = .0060), respectively. The Kaplan–Meier curve indicated that survival rates were higher when RCR was ≤ 1.83 and lower when RDW was > 1.83 after adjustment for age, gender, BMI, ethnicity. The area under curve (AUC) of RCR was 0.715. A higher RCR was associated with an increased risk of in-hospital mortality in patients with AIS.

show abstract

Section: The Authors Have No Funding and Conflicts Of Interest To Dis...mentioning

confidence: 99%

Red cell distribution width to total serum calcium ratio and in-hospital mortality risk in patients with acute ischemic stroke: A MIMIC-IV retrospective analysis

Zhang,

Shen,

Zhou

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“… 3 4 RDW is a quantitative parameter that indicates the degree of volume variation in erythroid cells and is customarily used in haematology to help diagnose anaemia. 5 Population-based studies have shown that RDW independently and directly predicts mortality in cardiovascular and other acute and chronic diseases such as AMI, heart failure, pulmonary hypertension, ischaemic stroke, coronavirus disease 2019, acute pancreatitis and acute kidney injury. 6–12 There is sufficient evidence to indicate that RDW is an effective parameter for predicting clinical prognosis and may have profound implications in clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database

Liu

Shen

et al. 2022

BMJ Open

View full text Add to dashboard Cite

ObjectivesWe aimed to investigate the association between red cell distribution width-to-platelet ratio (RPR), and in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).DesignA retrospective cohort study.SettingData were collected from the Medical Information Mart for Intensive Care database (MIMIC-IV) consisting of critically ill participants between 2008 and 2019 at the Beth Israel Deaconess Medical Centre in Boston.ParticipantsA total of 5067 patients with AMI were enrolled from the MIMIC-IV database.Primary and secondary outcomeIn-hospital mortality.ResultsA total of 4034 patients survived, while 1033 died. In a multiple regression analysis adjusted for age, weight and ethnicity, RPR also showed a positive correlation with in-hospital mortality (HR 1.91, 95% CI 1.42 to 2.56, p<0.0001). Moreover, after adjusting for additional confounding factors, obvious changes were observed (HR 1.63, 95% CI 1.03 to 2.57, p=0.0357). In model 2, the high ratio quartile remained positively associated with hospital mortality compared with the low ratio quartile (HR 1.20, 95% CI 1.01 to 1. 43), with a p-value trend of 0.0177. Subgroup analyses showed no significant effect modifications on the association between RPR and in-hospital mortality in the different AMI groups (p>0.05).ConclusionRPR is an independent predictor of in-hospital mortality in critically ill patients with AMI.

show abstract

Relationship Between Red Blood Cell Distribution Width and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis

Cited by 2 publications

References 25 publications

Red cell distribution width to total serum calcium ratio and in-hospital mortality risk in patients with acute ischemic stroke: A MIMIC-IV retrospective analysis

Red cell distribution width to total serum calcium ratio and in-hospital mortality risk in patients with acute ischemic stroke: A MIMIC-IV retrospective analysis

Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database

Contact Info

Product

Resources

About