Relationship between Primary Nodal Generalized Osteoarthritis with Tissue Antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey

Background: Osteoarthritis (OA) is a painful social problem, which breaks down the articular cartilage, causes the failure of synovial joints and subchondral bone sclerosis. OA etiology is not completely understood, but joint trauma, infection, obesity, and diseases are the most important risk factors for OA developing. Recent studies suggested inflammatory factors and genetic components can be involved in the pathogenesis of OA. Experimental evidences suggest a linkage between Human Leukocyte Antigen (HLA) genetic diversity and OA. But a few studies have been conducted in this subject. Objective: To investigate the association between HLA-DRB1*0101 and OA in Iranian patients. Methods: Thirty patients with knee osteoarthritis and 30 healthy people as the control group were included in the study. Sex, weight, age, Body mass index (BMI) and height of all participants were recorded. HLA-DRB1*0101 was typed by PCR using the sequence-specific primer. Results: Our results showed 80% of knee osteoarthritis patients were positively HLA-DRB1*0101 (n=24), while only 26.7% of controls were positive (n=8) (P= 0.015). Conclusion: These findings proposed that there is a significant association between HLADRB1* 0101 and susceptibility to knee osteoarthritis.

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The Association Between Knee Osteoarthritis and HLA-DRB1*0101 in the East of Iran

Kooshkaki

Atabati

Shayesteh

et al. 2020

CRR

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Association of HLA-DQB1 with the development of osteoarthritis

Al-Mukhtar¹,

Mahdi²,

Raouf³

et al. 2014

Gaziantep Med J

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Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of different joints in the body, which may lead to joint destruction and life disability. It is a complex disease of multifactorial etiology like genetic variation. Genetics is believed to be important in determining the susceptibility of OA. It was proven to be associated with histocompatibility locus antigen region. The aim of this study was to analyze of the frequencies of HLA-DQB1 alleles in OA Iraqi Arab Muslims. A cross-sectional case control comparative study included twenty six Iraqi Arab Muslims patients who had knee OA and admitted in the Orthopedic Department at Al-Kindy Teaching Hospital between September -2012 to June -2013, and compared to control ethnically matched group. HLA-DRQ1 genotyping was done by polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) method. There was an increased frequencies of HLA-DQB1*03:01:01 in patients with OA compared with healthy controls (P=0.0171, odds ratio=7.4118, 95% CI=1.4285-38.4564); also there were an increase in the HLA-DQB1* 02:01:01, HLA-DQB1* 0305 and *04 in patients with OA compared with the control group, but the differences were not statistically significant. Our results suggest a role of the HLA DQB1*03:01:01 system in the etiopathogenesis of OA.

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Relationship between Primary Nodal Generalized Osteoarthritis with Tissue Antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey

Cited by 2 publications

References 21 publications

The Association Between Knee Osteoarthritis and HLA-DRB1*0101 in the East of Iran

The Association Between Knee Osteoarthritis and HLA-DRB1*0101 in the East of Iran

Association of HLA-DQB1 with the development of osteoarthritis

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