Relationship between Preterm Labor and Thrombophilic Gene Polymorphism: A Prospective Sequential Cohort Study

Abstract

Objective: Premature labor is still the leading cause of infant mortality and morbidity worldwide. Multiple etiological factors including genetics and environment are held responsible for preterm birth. However, scientific data regarding the link between premature birth and genetics are limited. Subjects and Methods: In this study, we included 50 women who had premature labor (group 1) but did not have any known risks for a premature delivery such as uterine anomaly, polyhydramnios, hypertension, and diabetes mellitus, and another 50 healthy women who had term labor as control (group 2). We compared these two patient groups for MTHFR C677T, MTHFR C1298T, prothrombin 20210A, factor V and ACE polymorphisms. Results: We could not detect a statistical significance between groups for polymorphisms in MTHFR C677T, MTHFR C1298T, prothrombin 20210A, factor V and ACE polymorphisms. Conclusion: We investigated the relationship between premature and term labor and thrombophilic gene polymorphism. However, we found no associations with premature or term labor with the parameters included.

Association between SNPs in genes involved in folate metabolism and preterm birth risk

“…Good nutrition can reduce elevated hyperhomocysteinemia caused by mutations in the MTHFR gene. MTHFR-C677T and MTHF-A1298C showed only a minimal association with preterm delivery in both whites and blacks (Engel et al, 2006;Gargano et al, 2009) as well as in cases in Turkey (Uvuz et al, 2009) in some studies. Gargano also studied 560 whites and 399 blacks and showed that MTHFR-C677T and MTHFR-A1298C were only correlated with the placental-type premature birth, but had no correlation with the other types of premature births.…”

Skipping Meals and Less Walking Among African Americans Diagnosed With Preterm Labor

“…Recent genetic research has focused on infectious, thrombophilic, and renin‐angiotensin system pathways (Gargano et al, 2009; Kramer et al, 2009; Uvuz et al, 2009; Warren et al, 2009); however, no associations were found for thrombophilic gene polymorphisms and preterm labor (Kramer et al, 2009; Uvuz et al, 2009). Thrombophilic and renin‐angiotensin gene polymorphisms were associated with hemorrhage‐related preterm delivery, but not other types of preterm delivery (Gargano et al, 2009).…”

Factor V Leiden as a risk factor for preterm birth – a population‐based nested case–control study

“…Carriage of FII G20210A, which is rare in Finland, was not associated with preterm birth in our study. In the few other studies, the results have been controversial [8–12]. With our study population, the lowest OR for FII G20210A that would have been possible to detect with 80% power is 3.4.…”

“…No association between FV Leiden and preterm birth has been found in various studies [8–12]. Härtel et al.…”

“…FV Leiden, the most common known thrombophilic mutation in Caucasians, has been associated with several pregnancy complications [5]. Except for two preliminary findings [6,7], FV Leiden has not been associated with preterm birth in the current literature [8–12]. However, the role of FV Leiden as a risk factor for preterm birth is unclear, as the studies are few and mostly small.…”