has been spreading globally, causing over 340 000 deaths. 1 Based on the previous knowledge of two notable coronavirus outbreaks, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), it is suggested that pregnant women are particularly susceptible to adverse outcomes, including the need for endotracheal intubation, admission to an intensive care unit (ICU), acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), and even death. 2-4 Also, there is combined with a high incidence of adverse fetal outcomes, including stillbirth, fetal growth restriction, and preterm birth. However, current research suggests that maternal severity with COVID-19 is similar to that of non-pregnant women, with a rate of severe pneumonia at 0%-18%. 5,6 A few critically ill cases have also been reported, causing maternal death and fetal loss. This may indicate that the effect of novel coronavirus (COVID-19) infection on pregnant women may be different from that of SARS and MERS. It is well known that most pregnancy complications, such as hypertensive disorders of pregnancy, will be relieved after the termination of pregnancy. But for COVID-19, we found that postpartum exacerbation presented due to short-term pathophysiological changes immediately after delivery. 7 Gestational weeks of infection, the maturity of the fetus, disease severity, and postpartum exacerbation make the management of severe and critically ill cases of pregnant women with COVID-19 more difficult. This article is mainly to explore those issues and make some clinical suggestions.