Relationship between prefrontal function during a cognitive task and social functioning in male Japanese workers: A multi-channel near-infrared spectroscopy study

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

“…This finding is consistent with previous NIRS studies on patients with late-onset major depression [24], in healthy male workers [22] and in healthy adults [23]. In euthymic patients with BD, a functional magnetic resonance imaging (fMRI) study revealed a significant relationship between GAF scores and left dorsolateral prefrontal activation during the VFT [46].…”

“…Future investigations using a longitudinal design should consider the causal relationship between social function and prefrontal activation. The present association of social functioning with prefrontal activation during the VFT in BD patients should also be confirmed in a larger sample, particularly consisting of healthy volunteers, as a relationship between social adaptation as assessed by the SASS and prefrontal activation during a working memory task was found in 181 healthy male workers [22]. Another limitation was that all patients with BD were taking medications at the time of the study.…”

“…Higher scores were indicative of better social functioning. On the basis of principal component analyses in previous studies [22,28], we examined total scores as well as 3 subscores: (1) interpersonal relations, (2) interest and motivation, and (3) self-perception. Of note, the interpersonal relations factor consisted of the following 8 items: (6) family-seeking behavior, (7) family relationship quality, (8) gregariousness, (9) relationship-seeking behavior, (10) external relationship quality, (11) external relationship appreciation, (12) social attractiveness, (13) social compliance; the interest and motivation factor consisted of the following 8 items: (1) job interest or (2) housework interest, (3) work enjoyment, (4) interest in hobbies, (5) quality of spare time, (14) community involvement, (15) social inquisitiveness, (16) intellectual interest, and (21) control of surroundings; the self-perception factor consisted of the following 4 items: (17) communication difficulties, (18) rejection sensitivity, (19) vainness, and (20) difficulties in coping with resources [22,28].…”

“…Using SASS and NIRS imaging, previous studies have shown a positive correlation between SASS scores and prefrontal activation during a working memory task in healthy male workers [22], and during a VFT in healthy elderly adults [23]. Pu et al [24] also found that a reduction in frontopolar activation was correlated with lower SASS scores in patients with late-onset major depression.…”

Association between longitudinal changes in prefrontal hemodynamic responses and social adaptation in patients with bipolar disorder and major depressive disorder

“…Cognitive function can be a major determinant of social functioning in patients with various psychiatric disorders (Pu et al, 2013). Cross-sectional studies have shown that patients with bipolar disorder (BD) typically exhibit deficits in executive function (Ancín et al, 2013;Martino et al, 2013).…”