Relationship between pre-pregnancy maternal BMI with spontaneous preterm delivery and birth weight

Abstract

The aim of the present study was to find the relationship between pre-pregnancy maternal body mass index (BMI) with spontaneous preterm delivery and birth weight. A prospective cohort study was performed on 576 pregnant women. Maternal BMI was determined at the first prenatal visit between 8-12 weeks' gestation and considered as the pre-pregnancy maternal weight. The women were then monitored up to delivery. Out of 576 women, 396 completed the study. The demographics of the women in all BMI groups did not differ with regard to age, height, history of abortion and employment. A total of 21 women (5.3%) were underweight; 198 women (50%) were normal weight; 117 women (29.5%) were overweight and 60 (15.2%) were obese. There were no cases of morbidly obese (BMI > 40 kg/m(2)) women. Obesity in women had a positive correlation with higher gestational age at the time of delivery (r = 0.213, p = 0.015) and a heavier birth weight (r = 0.361, p = 0.008). Low birth weight had a correlation with low maternal BMI (r = 0.157, p = 0.041). Macrosomia was greater in obese women (p = 0.022) and BMI had a positive correlation with macrosomia (r = 0.224, p = 0.034). Preterm delivery showed a negative correlation with maternal BMI (r = -0.124, p = 0.004) and the women with a lower BMI had a greater number of preterm deliveries (p = 0.035).

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

“…Our findings help to explain the inconsistent findings between pre-pregnancy BMI and PTB outcomes reported in previous studies202122232425262728 and suggest that such inconsistency may be partly due to the interactions between maternal genotype (that is, rs11161721) and pre-pregnancy BMI. We showed that the impact of pre-pregnancy BMI on overall PTB risk depends on the maternal genotype at rs11161721.…”

“…First, maternal pre-pregnancy overweight/obesity (OWO) is prevalent in the BBC (>50%), which is significant from clinical and public health perspectives, and also ensures sufficient statistical power to identify a significant G × E interaction in this study. In addition, previous studies on the associations of pre-pregnancy BMI or OWO with PTB have yielded inconsistent results, including positive20212223, null2425 or negative associations262728. It is possible that such inconsistent findings may be in part due to maternal gene × pre-pregnancy BMI interaction29, which is largely unexplored.…”

Intrauterine growth restriction: distribution, risk factors, management of labour and outcome

“…However Sharifzadeh et al in the research found a positive correlation between SGA and low maternal BMI before pregnancy. 12 In the previous Latvian research, the average gestational time among the foetuses in IUGR was much smaller (36.3 weeks), but the caesarean was carried out more frequently. In our study, the average gestational time was 39.3 weeks.…”

The impact of maternal obesity in pregnancy on placental glucocorticoid and macronutrient transport and metabolism

“…Maternal BMI correlates positively with birthweight and the offspring are typically born heavier than those born to lean women [8,9]. Maternal obesity is associated with an elevated offspring risk of metabolic and cardiovascular disease in child-and adulthood including obesity, type 2 diabetes mellitus, coronary heart disease, stroke and cardiovascular disease [10][11][12].…”